Antiinflammatory effects of Cordia myxa fruit on experimentally induced colitis in rats

Al-Awadi, Farida; Srikumar, T.S.; Anim, Jehoram T.; Khan, Islam Ullah

doi:10.1016/s0899-9007(01)00517-2

Cited by 51 publications

(34 citation statements)

References 14 publications

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“…has been reported (Ficarra et al, 1995;Reddy et al, 2002;Agra et al, 2007). C. globosa and C. verbenacea have been used in the folk medicine for treatment of rheumatism, painful menstruation and gastric ulcer (Reddy et al, 2002;Al-Awadi, 2001). Some pharmacologically active metabolites with analgesic, antiinfl ammatory, antiarthritic and larvicidal activities were already purifi ed from Cordia sp., emphasizing an immunomodulatory activity of this genus (Sertié et al, 1991;Silva et al, 2003;Arrebola et al, 2004;Santiago et al, 2005).…”

Section: Discussionmentioning

confidence: 99%

Immunomodulatory activity of extracts from Cordia superba Cham. and Cordia rufescens A. DC. (Boraginaceae), plant species native from Brazilian Semi-arid

Costa¹,

David²,

David³

et al. 2008

Rev. bras. farmacogn.

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Section: Discussionmentioning

confidence: 99%

Immunomodulatory activity of extracts from Cordia superba Cham. and Cordia rufescens A. DC. (Boraginaceae), plant species native from Brazilian Semi-arid

Costa¹,

David²,

David³

et al. 2008

Rev. bras. farmacogn.

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“…Although the specific role of zinc in glucose metabolism is still speculative, low intake of dietary zinc was found to be associated with higher prevalence of diabetes among rural populations [7]. In several studies zinc supplementation (1 mg/L or 600 mg, daily) successfully decreased excess plasma glucose level, improved glucose disposal and lowered the incidence of diabetes [9,14,16]. But it is unclear why these studies used such large amounts of zinc for supplementation as these are several folds higher than the recommended daily intake of this element, which is only 5À16 mg.…”

Section: Discussionmentioning

confidence: 99%

“…Concentrations of trace elements in plants mixture, alfalfa extract, plasma, pancreas, and liver were determined by atomic absorption spectrometer. Approximately, 150 mg of plants mixture (mixed as described above), alfalfa, pancreas, and liver samples were digested (in a fume hood) using a mixture of 4 mL of concentrated nitric acid and 1 mL of perchloric acid [14]. The samples were heated on a heating block and temperature was gradually increased from 50 to 190°C until clear digests were obtained.…”

Section: Analytical Proceduresmentioning

confidence: 99%

Possible role of trace elements in the hypoglycemic effect of plants extract in diabetic rats

Al-Awadi

Anim

Srikumar

et al. 2004

J Trace Elements Exper Med

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The present study is designed to investigate the possible role of zinc, copper, manganese, and selenium on the hypoglycemic action of a plants mixture and alfalfa using a diabetic rat model. Diabetes was induced in male Wister rats using streptozotocin and confirmed by estimation of glucose levels in blood and urine and further by histologic examination of the pancreas. The animals were treated with the plants mixture and alfalfa extracts orally by gastric intubation for 7 days. Untreated normal and diabetic rats were included as controls. After evaluating glucose tolerance, animals were sacrificed and organs harvested for trace element analysis and histopathological study. The concentration of zinc, copper, manganese, and selenium in plasma, liver, and pancreas of diabetic rats was significantly lower than those of nondiabetic controls. Treatment of diabetic rats with plants mixture and alfalfa significantly decreased the blood glucose concentration but increased the levels of zinc, copper, manganese, and selenium in plasma, liver, and pancreas. Similar changes occurred in the nondiabetic normal control animals treated with the same products. Histological and immunohistochemical examination also confirmed the presence of more b-cells in the islets of treated diabetic animals compared with untreated diabetic controls. There was no histological evidence of damage to the liver of either diabetic or normal control animals treated with the plants extract. The present study indicated that treatment of diabetes with naturally available plants mixture appears to be effective and the hypoglycemic effect could be through a multimechanism action including that exerted by the trace element content in the different tissues including the pancreas.

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“…Bark powder was used externally in the treatment of skin diseases. Bark juice together with coconut oil was taken to treat colic 47,48 .…”

Section: Citrullus Colocynthismentioning

confidence: 99%

Therapeutic Properties and Nutritive Values of Some Fruit Bearing Medicinal Plants of Rajasthan State in India

Gupta¹,

Joshi²,

Madhudiya³

et al. 2017

PBJ

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Antiinflammatory effects of Cordia myxa fruit on experimentally induced colitis in rats

Cited by 51 publications

References 14 publications

Immunomodulatory activity of extracts from Cordia superba Cham. and Cordia rufescens A. DC. (Boraginaceae), plant species native from Brazilian Semi-arid

Immunomodulatory activity of extracts from Cordia superba Cham. and Cordia rufescens A. DC. (Boraginaceae), plant species native from Brazilian Semi-arid

Possible role of trace elements in the hypoglycemic effect of plants extract in diabetic rats

Therapeutic Properties and Nutritive Values of Some Fruit Bearing Medicinal Plants of Rajasthan State in India

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