Antiinflammatory <i>C</i>-Glucosyl Chromone from <i>Aloe barbadensis</i>

Hutter, John A.; Salman, Mohammad; Stavinoha, W. B.; Satsangi, Neera; Williams, Robert F.; Streeper, Robert T.; Weintraub, Susan T.

doi:10.1021/np9601519

Cited by 173 publications

(102 citation statements)

References 2 publications

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“…Authors have published many articles with the results suggestive of Anti-Inflammatory action of AloeVera. 17 This can be one the effect by which Aloe vera by virtue of its anti inflammatory property reduces glucotoxicity in diabetes.…”

Section: Discussionmentioning

confidence: 99%

Assessment of oral hypoglycaemic activity of water soluble extract of aloe vera and its interaction with glipizide in alloxan induced diabetic Wistar Rats

Tiwari

Gudsurkar

2017

Int J Basic Clin Pharmacol

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Background: Assessment of oral hypoglycaemic activity of water soluble extract of Aloe vera and its interaction with Glipizide in Alloxan induced diabetic Wistar rats.Methods: Under standard condition of testing, alloxan induced diabetic rats were kept in fasting state of 8 hours and then glucose in dose of 1gm/kg was given PO by feeding tube. There after water soluble extract of aloe vera in dose of 200mg/kg BW dissolves in 1ml of Distilled water (DW) to test group 1, Glipizide in dose of 2.5mg/kg BW dissolved in 1ml DW was given to standard group. Test group 2 received combination of Aloe vera 200mg/kg BW and Glipizide in dose of 2.5mg/kg BW dissolved in 1ml Dw. Control group received 1ml of Distilled water. Blood sugars levels of all Rats in each group were checked with Glucometer.Results: Clinically and statistically significant glucose lowering effect was observed in groups administered with Aloe vera and better results were observed in group receiving Aloe vera and Glipizide combination.Conclusions: Water soluble extract of aloe vera has significant hypoglycaemic activity and the results showed that co-administration of Aloe vera and Glipizide has superior hypoglycaemic activity compared to Aloe vera and Glipizide given Individually.

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Section: Discussionmentioning

confidence: 99%

Assessment of oral hypoglycaemic activity of water soluble extract of aloe vera and its interaction with glipizide in alloxan induced diabetic Wistar Rats

Tiwari

Gudsurkar

2017

Int J Basic Clin Pharmacol

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“…The Aloe vera (botanical name: Aloe barbadensis miller) is a member of Asphodelaceae (Liliaceae) family, and grows generally in the dry climates of Africa, Asia, Europe and America [16].…”

Section: Aloe Vera (Aloe Barbadensis Miller)mentioning

confidence: 99%

5 Medicinal Plants Used in Iranian Traditional Medicine for Low Back Pain: A Quick Review

Malek¹,

Abbasian²,

Karimi³

et al. 2017

Eur J Exp Bio

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Low back pain (LBP) is a common disorder and a considerable economic burden in industrialized countries. A large number of patients with LBP use complementary and alternative medicine for relief of their pain. Finding effective and suitable therapy is vital for these patients, clinicians and policy makers.Numerous herbal medications have been applied in treatment of LBP. The efficiency of these herbal medicines for the treatment of LBP is not without dispute; therefore, this review was conducted in order to evaluate the effectiveness of the five most widely used traditional therapies for the management of LBP.

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“…-methoxy-5-methylchromone) has been reported to have significant topical anti-inflammatory properties, comparable to those of hydrocortisone, without any reduction in thymus weight (as opposed to the classical hydrocortisone treatment) [105]. In fact, A. Vera has long been known to be a source of biologically relevant compounds with a wide range of health beneficial properties, namely glycosylated chromones [106].…”

Section: Chromones As Bioactive Agentsmentioning

confidence: 99%

Bioactive Chromone Derivatives – Structural Diversity

Machado¹,

Marques

2010

CBC

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Chromones (1-benzopyran-4-ones) and chromone derivatives are naturally occurring compounds ubiquitously found in the plant kingdom, and therefore present in representative amounts in a normal human diet. These phytochemicals possess a wide spectrum of biological activities -such as anti-inflammatory, antifungal, antimicrobial, antiviral, antitumour and anticancer -mainly due to their well-recognised antioxidant properties, which stem from their ability to neutralise active forms of oxygen and to cut off free radical processes.Since oxidative stress is known to be the basis for numerous severe pathologies, from cardiovascular and neurodegenerative disorders to cancer, the development of effective antioxidant agents from natural origin (namely dietary constituents) has been the object of vigorous research in the last decade, in view of establishing novel chemopreventive strategies against such diseases which are nowadays the main cause of death worldwide. In fact, the chromone moiety is an important element of pharmacophores of many biologically active molecules displaying diverse medicinal applications.These potential health benefits arising from the antioxidant activity of chromone derivatives are ruled by strict structureactivity/structure-property relationships, which, apart from determining their biological action, modulate their systemic distribution and bioavailability in sites of oxidation within the cell.The present work aims at reviewing the main reported studies on the cytoprotective and anticancer activities of chromone derivatives, with particular emphasis on the effect of their structural features and conformational behaviour on activity, which is the basis of a tailored design of novel chromone-based antioxidants for chemopreventive and chemotherapeutic use.

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Antiinflammatory C-Glucosyl Chromone from Aloe barbadensis

Cited by 173 publications

References 2 publications

Assessment of oral hypoglycaemic activity of water soluble extract of aloe vera and its interaction with glipizide in alloxan induced diabetic Wistar Rats

Assessment of oral hypoglycaemic activity of water soluble extract of aloe vera and its interaction with glipizide in alloxan induced diabetic Wistar Rats

5 Medicinal Plants Used in Iranian Traditional Medicine for Low Back Pain: A Quick Review

Bioactive Chromone Derivatives – Structural Diversity

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