Antiinflammatory natural products from marine algae

Mahmoud, Ayman M.; Bin-Jumah, May Nasser; Abukhalil, Mohammad H.

doi:10.1016/b978-0-12-819218-4.00012-2

Cited by 5 publications

(3 citation statements)

References 168 publications

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“…In addition, probiotics demonstrate synergistic effects when combined with polysaccharides or polymeric polyphenols, contributing to improved metabolic rates through digestion and improved gut microbiota composition [16]. The coexistence of specific bacteria with prebiotics, offering greater health benefits to the host than individual substances and producing synergistic effects via the production of bacterial metabolites, is referred to as synbiotics [17,18]. For example, the synergistic effects of Ligilactobacillus salivarius and the plant-derived prebiotic resveratrol have demonstrated efficacy in ameliorating colitis in mice through a reduction in inflammatory cytokine (IL-1β and IL-6) levels [19].…”

Section: Introductionmentioning

confidence: 99%

Phlorotannins Isolated from Eisenia bicyclis and Lactobacillus casei Ameliorate Dextran Sulfate Sodium-Induced Colitis in Mice through the AhR Pathway

Go,

Wang,

Park

et al. 2024

Applied Sciences

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Ulcerative colitis (UC), an inflammatory bowel disease (IBD) linked to colon cancer, needs effective natural preventive and therapeutic strategies to alleviate its clinical course. This study investigated the combined effects of phlorotannins (TAs) isolated from Eisenia bicyclis (E. bicyclis) and Lactobacillus casei (LC) on inflammatory markers in UC, with a focus on the aryl hydrocarbon receptor (AhR) axis. In vitro experiments revealed anti-inflammatory effects of the phlorotannin fraction isolated from E. bicyclis, especially in synergy with LC. In vivo experiments showed that a synbiotic combination of TAs and LC mitigated DSS-induced colitis and reduced intestinal shortening and splenic hypertrophy. The TA and LC combination suppressed inflammatory factors (IL-6, TNF-α, Lipocalin 2), while activating tight junction genes (Muc2, Zo-1, Occludin, and Claudin1) and enhancing antioxidant capacity (Nrf2 and Nqo1 genes). Activation of the AhR pathway, which is crucial for regulating intestinal inflammation via IL-22, was evident with both phlorotannin alone and synbiotic administration. The combination of TAs and LC amplified the synergistic effect on intestinal immunity and microbiota, favoring beneficial species and optimizing the Firmicutes/Bacteroidetes ratio. Overall, synbiotic use demonstrated superior preventive effects against UC, suggesting its potential benefits for improving the gut immune system through gut microbiota-derived metabolites.

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Section: Introductionmentioning

confidence: 99%

Phlorotannins Isolated from Eisenia bicyclis and Lactobacillus casei Ameliorate Dextran Sulfate Sodium-Induced Colitis in Mice through the AhR Pathway

Go,

Wang,

Park

et al. 2024

Applied Sciences

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“…Fucoidan (23), sulfated polysaccharide, was isolated from brown algae. Fucoidan was found to be effective against apoptosis in the human lymphoma HS-Sultan cell line [ 110 , 111 ]. National Cancer Institute, USA, carried out screening for the cytotoxic activity of the marine herb Portieria hornemannii and isolated halomon ( 24 )—a pentahalogenated monoterpene—and found out that this biosynthetic product was cytotoxic against cancer cell line [ 112 ].…”

Section: Introductionmentioning

confidence: 99%

The Chemotherapeutic Potentials of Compounds Isolated from the Plant, Marine, Fungus, and Microorganism: Their Mechanism of Action and Prospects

Shakya

Naik

2022

Journal of Tropical Medicine

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Research on natural products mainly focuses on developing a suitable drug to treat human disease. There has been a sharp increase in the development of drugs from natural products. Most of the drugs that are available are from the terrestrial origin. Marine natural products are less explored. Oceans are considered as a vast ecosystem with a wide variety of living organisms and natural products that are unexplored. Large numbers of antitumor drugs are from natural sources such as plants, marine, and microorganisms. 80% new chemical entities that were launched over the past 60 decades were from a natural source. In this article, the anticancer potential from the natural source such as plants, fungi, microorganisms, marine, and endophytes has been reviewed. Emphasis is given on the compound from the marine, plant, and of bacterial origin. Finally, we consider the future and how we might achieve better sustainability to alleviate human cancer suffering while having fewer side effects, more efficacies, and causing less harm than the present treatments.

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“…Due to the abuse of antibiotics, the bacteria are more resistant and antibiotic-resistant infections represent a major threat not only to humans, but also for terrestrial and aquatic animals (Bondad-Reantaso et al, 2023). Herbs and their constituents are considered an incredible source of therapeutically essential substances that may be utilized to treat a variety of diseases and provide health benefits (Mahmoud et al, 2021). Thousands of functional bioactive secondary substances from herbs were discovered via extensive publications published in the last century (Heidari et al, 2023;Swelum et al, 2021).…”

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confidence: 99%

Dietary Curcumin Nanoparticles Improve Growth Performance, Oxidative Status and Immune Response of European Seabass (Dicentrarchus Labrax)

Bin-Ammar,

Ahmeda,

Abdelkarim

et al. 2024

Annals of Animal Science

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A 90 days of feeding trial was employed for evaluating the effects of dietary supplementation with curcumin nanoparticles (CURNPs) on growth performance, hematological and biochemical parameters, immune response, antioxidant status, and intestinal and hepatic architecture in European seabass (Dicentrarchus labrax) fingerlings. Fish (n = 300, initial body weight = 10.02 g ± 0.11g) received supplementary CURNPs at rates of 0 (control; CURNPs0), 50 (CURNPs50), 100 (CURNPs100) and 150 (CURNPs150) mg/kg diet for 90 days. Growth performance (final body weight (FBW), daily weight gain (DWG), weight gain (WG), relative growth rate (RGR), and protein efficiency ratio (PER)) and feed uptake (feed conversion rate (FCR)) were improved significantly in CURNPs (100 and 150 mg/kg)-supplemented groups. The hematological parameters red blood corpuscles (RBCs), hemoglobin (Hb), and packed cell volume (PCV) were improved significantly (p < 0.001) in CURNPs150 and CURNPs100 groups, while CURNPs150 had the lowest values of monocytes (p = 0.019) and heterophils (p < 0.005) when compared with other groups. Glucose was higher and lipid profile (total cholesterol and triglycerides) were lower in all CURNPs-supplemented groups as compared to the control group. Fish fed with CURNPS at various levels exhibited remarkable increase in digestive enzymes (amylase and lipase), immune markers (immunoglobulin G (IgG), lysozyme and phagocytic indices), and antioxidant enzymes (superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx)). A noticeable decrease (p < 0.05) in malondialdehyde (MDA) and considerable upregulation of hepatic insulin-like growth factor 1 (IGF1) and interleukin-1beta (IL-1β) mRNA levels were found in CURNPs-supplemented fish in a dose-dependent manner. The down regulation of hepatic heat shock protein 70 (HSP70) was observed in CURNPs150. Intestinal and hepatic architectures were improved significantly by CURNPs. In conclusion, CURNPs supplementation improved growth performance, feed consumption and digestion, hematological and biochemical markers, immune response, and redox homeostasis in D. labrax. Therefore, CURNPs could be supplemented in the diets of D. labrax as a natural alternative to promote overall performance.

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Antiinflammatory natural products from marine algae

Cited by 5 publications

References 168 publications

Phlorotannins Isolated from Eisenia bicyclis and Lactobacillus casei Ameliorate Dextran Sulfate Sodium-Induced Colitis in Mice through the AhR Pathway

Phlorotannins Isolated from Eisenia bicyclis and Lactobacillus casei Ameliorate Dextran Sulfate Sodium-Induced Colitis in Mice through the AhR Pathway

The Chemotherapeutic Potentials of Compounds Isolated from the Plant, Marine, Fungus, and Microorganism: Their Mechanism of Action and Prospects

Dietary Curcumin Nanoparticles Improve Growth Performance, Oxidative Status and Immune Response of European Seabass (Dicentrarchus Labrax)

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