Antiinflammatory peptides: current knowledge and promising prospects

Dadar, Maryam; Shahali, Youcef; Chakraborty, Sandip; Prasad, Minakshi; Tahoori, Fatemeh; Tiwari, Ruchi; Dhama, Kuldeep

doi:10.1007/s00011-018-1208-x

Cited by 72 publications

(46 citation statements)

References 174 publications

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“…Inflammation is the natural response to situations such as physical injury or infections and has a significant role in wound healing and microbial resistance. However, prolonged, uncontrolled inflammation can lead to various chronic diseases ( Dadar et al, 2019 ). Several natural and synthetic peptides with immune-modulatory properties known as anti-inflammatory peptides (AIPs) have emerged as anti-inflammatory agents.…”

Section: Resultsmentioning

confidence: 99%

Decoding the proteome of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) for cell-penetrating peptides involved in pathogenesis or applicable as drug delivery vectors

Hemmati

Behzadipour

Haddad

2020

Infection, Genetics and Evolution

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Synthetic or natural derived cell-penetrating peptides (CPPs) are vastly investigated as tools for the intracellular delivery of membrane-impermeable molecules. As viruses are intracellular obligate parasites, viral originated CPPs have been considered as suitable intracellular shuttling vectors for cargo transportation. A total of 310 CPPs were identified in the proteome of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Screening the proteome of the cause of COVID-19 reveals that SARS-CoV-2 CPPs (SCV2-CPPs) span the regions involved in replication, protein-nucleotide and protein-protein interaction, protein-metal ion interaction, and stabilization of homo/hetero-oligomers. However, to find the most appropriate peptides as drug delivery vectors, one might face several hurdles. Computational analyses showed that 94.3% of the identified SCV2-CPPs are non-toxins, and 38% are neither antigenic nor allergenic. Interestingly, 36.70% of SCV2-CPPs were resistant to all four groups of protease families. Nearly 1/3 of SCV2-CPPs had sufficient inherent or induced helix and sheet conformation leading to increased uptake efficiency. Heliquest lipid-binding discrimination factor revealed that 44.30% of the helical SCV2-CPPs are lipid-binding helices. Although Cys-rich derived CPPs of helicase (NSP13) can potentially fold into a cyclic conformation in endosomes with a higher rate of endosomal release, the most optimal SCV2-CPP candidates as vectors for drug delivery were SCV2-CPP118, SCV2-CPP119, SCV2-CPP122, and SCV2-CPP129 of NSP12 (RdRp). Ten experimentally validated viral-derived CPPs were also used as the positive control to check the scalability and reliability of our protocol in SCV2-CPP retrieval. Some peptides with a cell-penetration ability known as bioactive peptides are adopted as biotherapeutics themselves. Therefore, 59.60%, 29.63%, and 32.32% of SCV2-CPPs were identified as potential antibacterial, antiviral, and antifungals, respectively. While 63.64% of SCV2-CPPs had immuno-modulatory properties, 21.89% were recognized as anti-cancers. Conclusively, the workflow of this study provides a platform for profound screening of viral proteomes as a rich source of biotherapeutics or drug delivery carriers.

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Section: Resultsmentioning

confidence: 99%

Decoding the proteome of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) for cell-penetrating peptides involved in pathogenesis or applicable as drug delivery vectors

Hemmati

Behzadipour

Haddad

2020

Infection, Genetics and Evolution

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“…In fact, each peptide could have a specific structure for their activity according to the followed molecular mechanism (Guha and Majumder, 2018). Up to date, several natural anti-inflammatory peptides derived from animal, plant, bacteria and marine organisms as well as synthetic peptides have been reported as potential candidates for reducing inflammation (Dadar et al, 2019). For example, the ACE-inhibitory tripeptide LSW from a soy protein hydrolysate has shown anti-inflammatory activity on vascular smooth muscle cells through its participation in several signaling pathways (Lin et al, 2017), whereas the casein-derived VPP modulated monocyte adhesion to vascular endothelium through its effect on a MAP kinase pathway (Aihara et al, 2009).…”

Section: Dry-cured Ham Cardioprotective Peptidesmentioning

confidence: 99%

Potential cardioprotective peptides generated in Spanish dry-cured ham

Gallego¹,

Mora²,

Toldrá³

2019

Journal of Food Bioactives

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Food-derived bioactive peptides are promising compounds for the prevention and treatment of cardiovascular diseases, the main cause of mortality in developed countries. The aim of this work was to determine the in vitro anti-inflammatory, antioxidant, and angiotensin I-converting enzyme (ACE-I) inhibitory activities of twenty-four peptides that were identified in Spanish dry-cured hams. For the first time, some peptides such as PSNPP, HCNK-KYRSEM and FNMPLTIRITPGSKA showed anti-inflammatory activity expressed as platelet-activating factor-acetylhydrolase, autotaxin, and lipoxygenase inhibition. Peptides MDPKYR and TKYRVP were the strongest antioxidants, whereas GGVPGG, TKYRVP, and HCNKKYRSEM showed the highest ACE-I inhibitory activity. Additionally, several peptides such as KPVAAP, MDPKYR, TKYRVP, and HCNKKYRSEM exerted more than one of the assayed activities, increasing their health-enhancing potential. More studies are needed to evaluate the bioavailability of such peptides and their in vivo effect. This would contribute to consider dry-cured ham as a source of peptides beneficial for cardiovascular health.

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“…On the other hand, an increasing interest concerns peptides as source of potential new therapeutic agents (Dadar et al, 2018), together with their use to complement existing genomic methodologies for deciphering complex biological processes (Delvaeye et al, 2018). Peptides are particularly well-suited to be modulators of protein functions.…”

Section: Peptides As Structural Biological Imprints Of Protein Targetsmentioning

confidence: 99%