Antiinflammatory triterpenoids and steroids from Ganoderma lucidum and G. tsugae

Ko, Horng‐Huey; Hung, Chi‐Feng; Wang, Jih-Pyang; Lin, Chun‐Nan

doi:10.1016/j.phytochem.2007.06.008

Cited by 125 publications

(85 citation statements)

References 22 publications

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“…They possess various beneficial effects, including antitumor, anticancer, antioxidant, anti-inflammatory, anti-atherosclerotic, and anti-diabetic (3)(4)(5)(6). In particular, these components are of great interest in the food industry because of their nutritional values (7).…”

Section: Introductionmentioning

confidence: 99%

Determination of Phytochemical Contents and Biological Activities from the Fruits of Elaeagnus multiflora

Lee¹,

Seo²,

Cho

2011

JFN

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The purpose of this study was to investigate the phytochemical contents and biological activities, including α-glucosidase inhibitory activity and antioxidant activity, from the fruits of Elaeagnus multiflora using different solvent systems. The 50% ethanol extract of this species showed the most potent α-glucosidase inibitory activity (88.5%) at a concentration of 1 mg/mL. Moreover, this extract also displayed the strongest antioxidant activity in each assay, showing 96.3% in DPPH scavenging activity, 98.2% in ABTS scavenging activity, and 2.5% in reducing power. The highest total phytochemical contents, including flavan-3-ols, phenolic acids, and flavonoids, were observed in the 50% ethanol extract. Interestingly, flavan-3-ols (3.150 mg/g) were detected at a significantly higher total content than those of phenolic acids (0.380 mg/g) and flavonoids (not detected). Additionally, the contents of individual phytochemicals showed remarkable differences, especially the epicatechin gallate (2.008 mg/g) and gallic acid (0.099 mg/g), which were the predominant constituents of each phytochemical type. Therefore, our results suggest that the 50% ethanol extract of E. multiflora fruits has strong biological activities, which are correlated with high phytochemical contents.

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Section: Introductionmentioning

confidence: 99%

Determination of Phytochemical Contents and Biological Activities from the Fruits of Elaeagnus multiflora

Lee¹,

Seo²,

Cho

2011

JFN

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“…In them immunomodulatory proteins, 13) triterpenoids, 14) and polysaccharides 15,16) are some of the desired products. Recently, many therapeutic effects have been reported for extracts from the fruiting body and mycelium of G. tsugae, including anti-tumor effects, 17) anti-inflammatory effects, 18) and antioxidfant activities, 9) but little is known about the antioxidant property of exopolysaccharides produced by submerged cultures of G. tsugae. The objective of the present study was to investigate the effects of exopolysaccharides from G. tsugae on HO-1 and TrxR-1 expression in endothelial cells.…”

mentioning

confidence: 99%

Isolating a Cytoprotective Compound fromGanoderma tsugae: Effects on Induction of Nrf-2-Related Genes in Endothelial Cells

Wei

Wung

Lin

et al. 2009

Bioscience, Biotechnology, and Biochemistry

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“…Splenic NK activity and serum IFN (IFN-(alpha+beta) and IFN-gamma) titers are elevated by G. tsugae mycelium extracts in mice (Won et al 1992). Moreover, it has been reported many pharmacological properties, such as anti-autoantibody formation (Lai et al 2001), anti-fibrosis (Wu et al 2004), anti-inflammation (Ko et al 2008), anti-oxidation characteristics (Mau et al 2002) and anti-mutagenic activities (Zheng et al 2005). Among the biologically active components, the polysaccharides, protein-bound polysaccharides and their derivatives have been demonstrated to be responsible for its antitumor activities, which are based on enhancing the host-mediated mechanism (Mizuno et al 1985, Wang et al 1993, Zhang et al 1994, Gao et al 2000, Seong 2000.…”

Section: Ganoderma Tsugaementioning

confidence: 99%

Mycosphere Essays 20: Therapeutic potential of Ganoderma species: Insights into its use as traditional medicine

Hapuarachchi¹

2017

Mycosphere

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The genus Ganoderma (Ganodermataceae) has a long history in traditional medicine to improve longevity and health in Asia. Ganoderma has been widely used in multiple therapeutic activities as well as dietary supplements to prevent and treat many diseases. Several classes of bioactive substances have been isolated and identified from Ganoderma, such as polysaccharides, triterpenoids, nucleosides, sterols, fatty acids, protein and alkaloids. There are numerous research publications, which report the abundance and variety of biological actions initiated by the metabolites of Ganoderma. Investigation on different metabolic activities of Ganoderma species has been performed both in vitro and in vivo. In many cases, however, it has been questioned whether Ganoderma is solely a nourishment supplement for wellbeing or merely a helpful "medication" for restorative purposes. There has been no any conclusive report of human trials using Ganoderma species as a direct control agent for diseases. In addition, there is no evidence supporting the usage of Ganoderma species (excluding G. lucidum) as potential supplements for cancer or other diseases in humans since no preclinical trials have been performed up to date. In this review, the beneficial medicinal properties of several species of Ganoderma (excluding G. lucidum) and their secondary metabolites are discussed. Ganoderma species can be used as a therapeutic drug, but more direct scientific evidence should be made available in the future. The efficiency of Ganoderma in clinical treatments should be substantiated with more biomedical research and their true impact assessed on human health with more standardized clinical evaluations so that the feasibility of biologically active extracts of Ganoderma species in alternative treatments can be recommended.

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Antiinflammatory triterpenoids and steroids from Ganoderma lucidum and G. tsugae

Cited by 125 publications

References 22 publications

Determination of Phytochemical Contents and Biological Activities from the Fruits of Elaeagnus multiflora

Determination of Phytochemical Contents and Biological Activities from the Fruits of Elaeagnus multiflora

Isolating a Cytoprotective Compound fromGanoderma tsugae: Effects on Induction of Nrf-2-Related Genes in Endothelial Cells

Mycosphere Essays 20: Therapeutic potential of Ganoderma species: Insights into its use as traditional medicine

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