Antiinfluenzal Effect of Rugulosin

Nakamura, Shinichi; Nii, Fusako; Inoue, Satoru; Nakanishi, Isao; Shimizu, Masanao

doi:10.1111/j.1348-0421.1974.tb00736.x

Cited by 7 publications

(1 citation statement)

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“…The naturally occurring bisanthraquinones cytoskyrin A ( 1a ), graciliformin ( 1b ), 2,2‘- epi -cytoskyrin A ( 2a ), rugulosin ( 2b ), rugulin ( 3 ), deoxyrubroskyrin ( 4 ),4b 1,1‘-bislunatin ( 5a ), skyrin ( 5b ) 4b, and flavoskyrin ( 6 ),4d all shown in Figure , represent an impressive and growing class of compounds with varying degrees of structural complexity. Isolated from a number of fungi and lichens, these molecules exhibit a diverse array of biological activities including cytotoxic ( 1a , 1b , 2b ), antibacterial ( 3 ), insecticidal ( 2b ), anti-influenzal ( 2b ), and anti-HIV ( 2b ) properties. The most recent members of the family are cytoskyrin A ( 1a ), isolated from small-scale cultures of the endophytic fungus CR200 ( Cytospora sp . )…”

Section: Introductionmentioning

confidence: 99%

Total Syntheses of 2,2‘-epi-Cytoskyrin A, Rugulosin, and the Alleged Structure of Rugulin

et al. 2007

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The total syntheses of 2,2'-epi-cytoskyrin A, rugulosin, and the alleged structure of rugulin are described. These naturally occurring bisanthraquinones and their relatives are characterized by novel molecular architectures at the core, at which lies a more or less complete, cage-like structural motif termed "skyrane". The strategies developed for their total synthesis feature a cascade sequence called the "cytoskyrin cascade" and deliver these molecules in short order and in a stereoselective manner.

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