Antikeratin antibodies: diagnostic and prognostic markers for early rheumatoid arthritis.

Paimela, Leena; Gripenberg, Marianne; Kurki, Pekka; Leirisalo‐Repo, Marjatta

doi:10.1136/ard.51.6.743

Cited by 75 publications

(42 citation statements)

References 21 publications

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“…However, there was no difference in AFA positivity between the patients with and without marginal erosion in our patient group. It was reported that the frequency of RF is increased in AKA or APF positive patients (Paimela et al, 1992). In this study, the frequency of RF positivity tended to be higher in AFA positive patients compared with AFA negative patients (89% versus 67%, P = 0.18).…”

Section: Discussionsupporting

confidence: 48%

“…The reported prevalence of AFA was variable (12.0-67.9%) and in case of AKA, the Greek patients with RA had low positivity (16%) in spite of consistently high positivity (36-69%) in other ethnic groups. AKA and APF could be positive at subclinical stage of RA (Paimela et al,1992) and IgG AKA was found in 38% of RA patients whose disease duration is less than one year (Aho et al, 1993). AKA and APF were suggested to be early diagnostic markers of RA.…”

Section: Discussionmentioning

confidence: 99%

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Clinical significance of anti-filaggrin antibody recognizing uncitrullinated filaggrin in rheumatoid arthritis

et al. 2005

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Filaggrin is expressed in the cornified layer of epidermis and known to be one of the antigenic targets in rheumatoid arthritis. Although the citrulline residue in filaggrin is thought to be an antigenic determinant recognized by autoantibodies, the diagnostic sensitivity of synthetic citrullinated peptide is variable. To investigate the implication of anti-filaggrin antibodies recognizing uncitrullinated filaggrin in rheumatoid arthritis, we assayed antibody titers using unmodified recombinant filaggrin in the sera from 73 patients with rheumatoid arthritis, 150 patients with other connective tissue diseases and 70 normal controls. We also performed the correlation analysis between antibody titers and the clinical variables in patients with rheumatoid arthritis. Titers of IgG anti-filaggrin antibodies were significantly higher in rheumatoid arthritis patients compared to normal controls (P = 0.02), but not in patients with osteoarthritis, ankylosing spondylitis or systemic lupus erythematosus. IgG anti-filaggrin antibodies were more frequently found in patients with rheumatoid arthritis compared to normal controls (12.3% vs 1.4% respectively, P = 0.04). An anti-filaggrin antibody titer was correlated with visual analogue scale of pain, tender joint count, Ritchie articular index or C-reactive protein, but not with anti-nuclear antibody or rheumatoid factor. These results suggest that anti-filaggrin antibody recognizes the uncitrullinated filaggrin as an antigen and its titer correlates with clinical parameters, explaining the variable sensitivity of anti-filaggrin antibody test.

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Section: Discussionsupporting

confidence: 48%

Section: Discussionmentioning

confidence: 99%

Clinical significance of anti-filaggrin antibody recognizing uncitrullinated filaggrin in rheumatoid arthritis

et al. 2005

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“…This is not due to poor specificity of the test, since several studies (11)(12)(13)(14), including our own (ref. 15 and unpublished observations), have demonstrated the high specificity of AKA for RA.…”

Section: Discussionmentioning

confidence: 99%

“…Earlier studies have shown that AKA also occur in seronegative RA, although at lower frequency than in seropositive RA (11)(12)(13)(14)(15). Those studies used the sensitized sheep-cell agglutination test to detect RF.…”

Section: Discussionmentioning

confidence: 99%

Immunopathology of rheumatoid arthritis

Kurki

Aho

Palosuo

et al. 1992

Arthritis & Rheumatism

106

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Objective. We sought to determine whether circulating antikeratin antibodies (AKA) precede the onset of rheumatoid arthritis (RA).Methods. By matching the registers of 2 previous population studies with the registry of patients receiving antirheumatic drugs several years later, pre-illness serum specimens could be obtained from 39 individuals who subsequently developed RA. AKA were assayed with the standard indirect immunofluorescence technique.Results. Ten of 39 serum specimens from individuals who subsequently developed seropositive RA, and 1 of 15 sera from individuals who developed seronegative RA, were positive for IgG-class AKA by immunofluorescence assay. The AKA-positive sera were also positive for rheumatoid factors.Conclusion. The findings focus attention on the role of pre-illness immunologic events in the pathogenesis of RA.Patients with rheumatoid arthritis (RA) display a variety of abnormalities of humoral immunity. Besides rheumatoid factors (RF), antibodies against collagen (l), Epstein-Barr virus (EBVhncoded nuclear

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“…AKA were found to be associated with more severe and/or active forms of RA [14.34], to be detected at early stages [34] and even to precede the clinical onset of the disease [35].…”

Section: Discussionmentioning

confidence: 99%

The rheumatoid arthritis-associated autoantibodies to filaggrin label the fibrous matrix of the cornified cells but not the profilaggrin-containing keratohyalin granules in human epidermis

Simon

Vincent

Haftek

et al. 1995

Clinical and Experimental Immunology

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SUMMARYSince they were first described, serum TgG antibodies to the stratum corneum of rat oesophagus epithetium. highty specific for rheumatoid arthritis (RA). have been consensuatty catted antikeratin antibodies (AKA). However, we recently demonstrated that they actually recognize three new proteins of rat oesophagus epithetium distinct from cytokeratins. and also human epidermat fitaggrin. In this work we provided further evidence that AKA and RA-associated anti-fitaggrin autoantibodies are the same antibodies. Moreover, analysing by indirect immunofluorescence on human skin a large series of 212 well characterized RA sera and anti-fitaggrin autoantibodies purified from RA sera by affinity chromatography. we demonstrated the specific binding of AKA to the stratum corneum of human epidermis and the absence of any staining of the granular keratinocytes. This binding was confirmed and the AKA antigen precisety locatized in human epidermis by immunoelectron microscopy. The antigen was found to be restricted to the fitaggrincontaining intraceltular fibrous matrix of the corneocytes, up to the desquamating cetls. In contrast. MoAbs directed to human filaggrin and to profitaggrin. its precursor, not onty stained the intracettutar matrix ofthe tower corneocytes but atso the keratohyatin granutes of the granular cetts, where profitaggrin is stored. These results reinforced by the absence of immunoblotting reactivity of RA sera to profilaggrin suggest that the epitopes recognized by AKA are absent from profilaggrin. Their identification may provide more insight into the pathogenesis of RA.

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Antikeratin antibodies: diagnostic and prognostic markers for early rheumatoid arthritis.

Cited by 75 publications

References 21 publications

Clinical significance of anti-filaggrin antibody recognizing uncitrullinated filaggrin in rheumatoid arthritis

Clinical significance of anti-filaggrin antibody recognizing uncitrullinated filaggrin in rheumatoid arthritis

Immunopathology of rheumatoid arthritis

The rheumatoid arthritis-associated autoantibodies to filaggrin label the fibrous matrix of the cornified cells but not the profilaggrin-containing keratohyalin granules in human epidermis

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