Antikörper gegen Viren der Herpesgruppe im Liquor cerebrospinalis bei idiopathischer Fazialisparese

Mees, K.; Wolf, H.

doi:10.1055/s-2007-1008646

Laryngo-Rhino-Otol

1982

DOI: 10.1055/s-2007-1008646

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Antikörper gegen Viren der Herpesgruppe im Liquor cerebrospinalis bei idiopathischer Fazialisparese

K. Mees¹,

H. Wolf²

Abstract: Die idiopathische Fazialisparese steht unter den Mononeuropathien im Bereich der Hirnnerven zah1enmãLig an erster Stelle. Die Atiologie dieser akut, häufig Nacht auftretenden Lähmung, ist immer noch ungeklart. Eine Besonderheit des 7. Hirnnerven, die ihn von den ubrigen Hirnnerven unterscheidet, steilt scm Verlauf im Felsenbein, in einem langen knöchernen Kanal dar, der am Boden des inneren Gehorganges beginnt und am Foramen stylomastoideum zu Ende ist und insgesamt die beachtliche Lange von 30 mm aufweisen ka… Show more

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Cerebrospinal fluid immunoglobulins and virus-specific antibodies in disorders affecting the facial nerve

1987

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Sixty-two patients with acute idiopathic peripheral facial nerve palsy (AIPFP) and 31 patients with lymphocytic meningoradiculitis (Garin-Bujadoux or Bannwarth's syndrome) are described. Results of cerebrospinal fluid (CSF) analysis, including the measurement of immunoglobulins (Ig) G, A, and M, indicate that pleocytosis and/or disturbance of the blood-CSF barrier (BCB) and/or local immunoglobulin synthesis within the central nervous system (CNS) do occur in about 25% of patients with AIPFP. The commonest finding is a slight to moderate breakdown of BCB function without evidence of intrathecal immunoglobulin synthesis. In only about 10% of patients, further support for an inflammatory process within the CNS is found by intrathecal synthesis of oligoclonal IgG and/or localized synthesis of IgG and/or IgA. The majority of cases (75%) do not show any signs of an inflammatory process within the CNS. In contrast, lymphocytic meningopolyradiculitis (LMR) has a characteristic CSF profile with early impairment of BCB permeability as well as with rapid and predominant intrathecal IgM synthesis, which helps to distinguish monosymptomatic LMR from AIPFP. By applying a sensitive enzyme-linked immunosorbent assay to identical concentrations of IgG in serum and CSF, evidence of intrathecal synthesis of virus-specific antibodies was found only in 2 of 13 patients with AIPFP. In contrast, all 4 patients with herpes zoster oticus and peripheral facial palsy (Ramsay Hunt syndrome) showed an intrathecal IgG synthesis to varicella zoster virus lasting for up to 4 months after onset of disease.

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Cerebrospinal fluid immunoglobulins and virus-specific antibodies in disorders affecting the facial nerve

1987

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Acute peripheral facial palsy: CSF findings and etiology

Roberg¹,

Ernerudh

Forsberg³

et al. 2009

Acta Neurologica Scandinavica

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CSF and serum were examined in acute and convalescence phase from 56 patients with acute idiopathic peripheral facial palsy. CSF protein analysis, viral and borrelia serology were performed. Borrelia infection was found in 9/56 cases and was often associated with inflammatory CSF findings. One patient each had serological evidence for a recent or ongoing infection with herpes simplex, varicella zoster, adeno, influenza B, echo and Epstein‐Barr virus, but none had specific intrathecal antibody synthesis; 11 patients had a serological pattern compatible with a reactivated Epstein‐Barr virus infection. Eleven patients displayed mononuclear CSF pleocytosis. Four of them had a borrelia infection. A disturbed blood‐brain barrier was observed in 19 patients. Intrathecal immunoglobulin synthesis as indicated by elevated IgM‐indices was found in 16 patients and by IgG indices in three. Nine patients had oligoclonal IgG bands in serum and CSF, three exclusively in CSF. It is concluded that patients with facial palsy often have inflammatory CSF findings, indicating a generalised central nervous system affection, and not only a mononeuritis. The importance of viral infections in the pathogenesis is still obscure. Borrelia is the most common infectious cause of facial palsy.

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Anti-herpes IgG and IgG Subclass Antibodies in Bell's Palsy

Jönsson¹,

Sundqvist²,

Thomander³

1988

Acta Oto-Laryngologica

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To ascertain if there is an association between Bell's palsy and infection by viruses of the herpes group, 78 patients and 59 controls were investigated. The specific antiviral IgG subclass pattern in serum against cytomegalovirus (CMV), herpes simplex virus type 1 (HSV-1) and varicella zoster virus (VZV) was analysed using an enzyme-linked immunosorbent assay (ELISA) combined with monoclonal antibodies directed against the four subclasses of human IgG. Additional ELISA assays of IgG and IgM antibodies were also used. The mean titres of IgG antibodies against HSV-1 were higher in the acute and convalescent stages compared with controls. The frequency of values greater than 0.2 for all subclasses was raised in the patients, but not significantly so. The mean values for the subclasses were alike in patients and controls. The mean titres of IgG antibodies against CMV and VZV were similar throughout the palsy and also in controls. In the patients, the pattern of IgG subclasses was different from the controls, but not statistically so. The patients and controls were not seropositive for IgM against CMV and VZV. Four patients in the acute phase, 4 in the convalescent phase and 3 controls were positive for IgM against HSV-1. While the subclass pattern of IgG antibodies against HSV-1 is not diagnostic of reactivation of the virus, the raised IgG antibodies may suggest reactivation of a disease process and/or a superadded infection.

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Antikörper gegen Viren der Herpesgruppe im Liquor cerebrospinalis bei idiopathischer Fazialisparese

Cited by 3 publications

References 0 publications

Cerebrospinal fluid immunoglobulins and virus-specific antibodies in disorders affecting the facial nerve

Cerebrospinal fluid immunoglobulins and virus-specific antibodies in disorders affecting the facial nerve

Acute peripheral facial palsy: CSF findings and etiology

Anti-herpes IgG and IgG Subclass Antibodies in Bell's Palsy

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