Antileishmania and immunomodulatory potential of cashew nut shell liquid and cardanol

Ribeiro, Iuliana Marjory Martins; Sousa, Valéria Carlos de; Melo, Evellyn Caroline Silva; Carvalho, Rita de Cássia Viana de; Santos, Maisa de Sousa dos; Neto, José Arimatéia de Oliveira Nery; Melo, Danielly Silva de; Teixeira, Letícia Soares de Araújo; Citó, Antônia Maria das Graças Lopes; Moura, Arkellau Kenned Silva; Arcanjo, Daniel Dias Rufino; Carvalho, Fernando Aécio de Amorim; Alves, Michel Muálem de Moraes; Mendonça, Ivete Lopes de

doi:10.1016/j.tiv.2022.105524

Cited by 4 publications

(3 citation statements)

References 75 publications

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“…The administration was performed with a 0.3-mL syringe, and the substances were inoculated into the third false leg of the larvae of the respective groups. Five days after the administration, photographic records were obtained for visual evaluation of the larvae, in addition to the evaluation of the survival rate of the groups and the degree of melanization they presented [37]. The melanization ratio was observed by skin pigmentation and applied at the ratio of melanizated ratio = number o f melanizated larvae total number o f larvae per group × 100…”

Section: The Evaluation Of the In Vivo Toxicity And Antioxidant Poten...mentioning

confidence: 99%

“…Then, homogenates were aliquoted into eppendorfs and centrifuged into a microcentrifuge (1460 rpm for 30 min, 4 • C). Then, the supernatant was separated and centrifuged again at 1370 rpm for 90 min (4 • C) [37]. This second supernatant, diluted in the respective buffer specific for each analysis, was used to follow up on the methodologies.…”

Section: The Evaluation Of the In Vivo Toxicity And Antioxidant Poten...mentioning

confidence: 99%

“…Major From the data in Table 5, the groups that received the SLN/TW-1.5 showed a higher rate of melanization and, therefore, are the groups that had the highest elevation in immune response, and this is associated with greater tissue response to these formulations. This greater tissue response is understandable as being an indicator of greater biological activity, mediated either by greater pharmacological or toxicological activity or by better kinetic action of the particles of the formulation in question [37].…”

Section: The Evaluation Of the Antioxidant Activity In Zophobas Morio...mentioning

confidence: 99%

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Solid Lipid Nanoparticles from Platonia insignis Seeds, a Brazilian Amazon Fruit: Characterization, In Vitro and In Vivo Toxicological and Antioxidant Activities

Coêlho,

de Almeida,

Santos

et al. 2023

J. Compos. Sci.

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Solid Lipid Nanoparticles (SLNs) are drug delivery systems with important advantages over conventional nanosystems. Considering previously reported pharmacological and physicochemical properties of Platonia insignis seed butter (BBI), this work aimed at developing, characterizing and performing toxicological and antioxidant studies of SLNs produced from BBI. The GC-MS analysis identified palmitic and oleic acids as the major compounds. Three SLN prototypes were developed through high-shear homogenization followed by ultrasonication. During a 180-day stability evaluation, the formulation SLN/TW-1.5 presented greater stability since pH was around 6.0, as well as a lesser variation of the PdI (Polydispersity Index), particle size and Zeta Potential (ZP), confirmed with Raman Spectroscopy and Atomic Force Microscopy (AFM). The CC50 in macrophages was around 249.4 µg∙mL−1 for BBI, whereas the CC50 value for SLN/TW-1.5 was 45.2 µg∙mL−1. Electron Paramagnetic Resonance (EPR) showed a marked in vitro antioxidant activity for BBI and SLN/TW-1.5. After in vivo SLN/TW-1.5 administration in Zophobas morio larvae, assessment of reduced glutathione (GSH), nitrite (NO2−) and myeloperoxidase (MPO) demonstrated antioxidant activity. Thus, the intrinsic physicochemical properties of BBI allowed the development of an optimized nanoformulation with high stability indexes, besides the great potential for antioxidant applications.

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Section: The Evaluation Of the In Vivo Toxicity And Antioxidant Poten...mentioning

confidence: 99%

Section: The Evaluation Of the In Vivo Toxicity And Antioxidant Poten...mentioning

confidence: 99%

Section: The Evaluation Of the Antioxidant Activity In Zophobas Morio...mentioning

confidence: 99%

See 1 more Smart Citation

Solid Lipid Nanoparticles from Platonia insignis Seeds, a Brazilian Amazon Fruit: Characterization, In Vitro and In Vivo Toxicological and Antioxidant Activities

Coêlho,

de Almeida,

Santos

et al. 2023

J. Compos. Sci.

Self Cite

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Anti‐Inflammatory Activity and Acute Toxicity Of Pereskia aculeata, In Zophobas morio Larvae

e Silva,

Nunes,

Prado da Silva

et al. 2024

Chemistry & Biodiversity

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Pereskia aculeata has been widely investigated due to its anti‐inflammatory potential. Among the metabolites found in this species are the phytosterols beta‐sitosterol (β‐SIT) and stigmasterol (STIG). The objective of the study was to evaluate the anti‐inflammatory and toxicity activities of the hexane partition of P. aculeata (PHEX), as well as β‐SIT and STIG. PHEX was prepared and the phytosterols were quantified. In terms of toxicity against L929 fibroblast cells, PHEX showed toxicity up to 200 µg/mL; STIG and β‐SIT showed toxicity up to 25 µg/mL. PHEX inhibited 66% of nitric oxide radicals, while STIG and β‐SIT inhibited 33.73% and 34.94%, respectively. In an anti‐inflammatory test against Zophobas morio larvae, all samples significantly reduced hemocyte levels. Additionally, the LD50 values were calculated: 229.6 mg/kg for PHEX, 101.5 mg/kg for STIG, and 103.8 mg/kg for β‐SIT. In conclusion, the study indicates that the phytosterols present in PHEX may contribute to its anti‐inflammatory activity.

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Investigation on torsional forces and angles at the nut and pedicel junction (NPJ) revealed varying cashew apple (hypocarp) and nut separation efficiency at different developmental stages in cashew

Manjunatha,

Savadi,

Naik

et al. 2024

Industrial Crops and Products

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Antileishmania and immunomodulatory potential of cashew nut shell liquid and cardanol

Cited by 4 publications

References 75 publications

Solid Lipid Nanoparticles from Platonia insignis Seeds, a Brazilian Amazon Fruit: Characterization, In Vitro and In Vivo Toxicological and Antioxidant Activities

Solid Lipid Nanoparticles from Platonia insignis Seeds, a Brazilian Amazon Fruit: Characterization, In Vitro and In Vivo Toxicological and Antioxidant Activities

Anti‐Inflammatory Activity and Acute Toxicity Of Pereskia aculeata, In Zophobas morio Larvae

Investigation on torsional forces and angles at the nut and pedicel junction (NPJ) revealed varying cashew apple (hypocarp) and nut separation efficiency at different developmental stages in cashew

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