Antileishmanial activity of isolated triterpenoids from Pourouma guianensis

Torres-Santos, Eduardo Caio; Lopes, Daniel Simões; Oliveira, Rodrigo Rodrigues de; Carauta, Jorge Pedro Pereira; Falcão, Camila Alves Bandeira; Kaplan, Maria Auxiliadora Coelho; Rossi-Bergmann, Bartira

doi:10.1078/0944-7113-00381

Cited by 106 publications

(63 citation statements)

References 15 publications

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“…This compound was shown to be active in Plasmodium falciparum [25][26][27] and perhaps has anti-leishmanial activity. The inhibiting activity of triterpenoids isolated is described for promastigotes [28,29] and intracellular amastigotes of Leishmania amazonensis [28]. amazonensis was inhibited (IC 50 = 67 µM) [31].…”

Section: Discussionmentioning

confidence: 99%

Anti-promastigote Activity of the Amazon Plants

Silva-Silva¹,

Monteiro²,

Brígido³

et al. 2017

JPP

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This study evaluated in vitro activity of ethanol extract, fractions, and isolated substance from Amazon species against promastigotes of L. amazonensis. The ethanol extracts were concentrated and fractionation. The anti-promastigote activity was evaluated through the cell viability assessment method (MTT). The ethanol extract, fractions, and isolated substance from Himatanthus articulatus and Parahancornia fasciculata were inactive in promastigote of L. amazonensis, as the ethanol extract of Physalis angulata. The hexane fractions from different parts of Montrichardia linifera showed anti-promastigote activity probably due to the presence of steroids and terpenes. All species in studies were inactive, except of M. linifera. The few polar constituents can be responsible for the activity. Therefore, the isolation and purification of the active on L. amazonensis promastigotes are urgently required.

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Section: Discussionmentioning

confidence: 99%

Anti-promastigote Activity of the Amazon Plants

Silva-Silva¹,

Monteiro²,

Brígido³

et al. 2017

JPP

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“…Triterpenoids contents in all BP parts by HPLC-DAD According to pharmacological and phytochemical reports on Moraceae plants, they possess antinociceptive and antiinflammatory potency and enrich certain triterpenoid constituents such as betulinic acid, ursolic acid, and oleanolic acid. [12][13][14][15][16] The above triterpenoids possess antinociceptive and anti-inflammatory activity in rodents. [17][18][19] Hence, we further measured the triter- Each value is represented as mean AE SEM (N ¼ 7{10).…”

Section: Effects Of Bp Radix and Fruit On The Microvascular Permeabilmentioning

confidence: 99%

Comparison with Various Parts ofBroussonetia papyriferaas to the Antinociceptive and Anti-Inflammatory Activities in Rodents

Lin

Chen²,

Wu³

et al. 2008

Bioscience, Biotechnology, and Biochemistry

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“…However, other studies with UA reported much higher IC 50 of 2·28 µg mL −1 against L. amazonensis (Torres- Santos et al 2004), 3·7 µg mL −1 against L. donovani (da Silva Filho et al 2009) and 4·55 µg mL −1 against Leishmania tarentolae (Graziose et al 2012). Some structural modification of UA led to reduction in activity as reported for 2α-hydroxy-ursolic acid (90) and uvaol (92) (IC 50 19 and 15 µg mL −1 respectively against L. donovani) (da Silva Filho et al 2009).…”

Section: Anti-leishmanial Activities Of Ptsmentioning

confidence: 87%

A systematic review of pentacyclic triterpenes and their derivatives as chemotherapeutic agents against tropical parasitic diseases

et al. 2016

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S U M M A R YParasitic infections are among the leading global public health problems with very high economic and mortality burdens. Unfortunately, the available treatment drugs are beset with side effects and continuous parasite drug resistance is being reported. However, new findings reveal more promising compounds especially of plant origin. Among the promising leads are the pentacyclic triterpenes (PTs) made up of the oleanane, ursane, taraxastane, lupane and hopane types. This paper reviews the literature published from 1985 to date on the in vitro and in vivo anti-parasitic potency of this class of phytochemicals. Of the 191 natural and synthetic PT reported, 85 have shown high anti-parasitic activity against various species belonging to the genera of Plasmodium, Leishmania, Trypanosoma, as well as various genera of Nematoda. Moreover, structural modification especially at carbon 3 (C3) and C27 of the parent backbone of PT has led to improved anti-parasitic activity in some cases and loss of activity in others. The potential of this group of compounds as future alternatives in the treatment of parasitic diseases is discussed. It is hoped that the information presented herein will contribute to the full exploration of this promising group of compounds as possible drugs for parasitic diseases.

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Antileishmanial activity of isolated triterpenoids from Pourouma guianensis

Cited by 106 publications

References 15 publications

Anti-promastigote Activity of the Amazon Plants

Anti-promastigote Activity of the Amazon Plants

Comparison with Various Parts ofBroussonetia papyriferaas to the Antinociceptive and Anti-Inflammatory Activities in Rodents

A systematic review of pentacyclic triterpenes and their derivatives as chemotherapeutic agents against tropical parasitic diseases

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