Antileishmanial Activity of Medicinal Plants Used in Endemic Areas in Northeastern Brazil

Queiroz, Aline Cavalcanti de; Dias, Thays de Lima Matos Freire; Matta, Carolina Barbosa Brito da; Cavalcante-Silva, Luiz Henrique Agra; Araújo-Júnior, João Xavier de; Araújo, Givanildo Bernardino de; Moura, Flávia de Barros Prado; Alexandre-Moreira, Magna Suzana

doi:10.1155/2014/478290

Cited by 29 publications

(19 citation statements)

References 45 publications

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“…De Queiroz et al [55] investigated the leishmanicidal activity of five species of plants used in folk medicine in Brazil in patients with CL (L. amazonensis). The plant extracts Hyptis pectinata (L.) Poit, Aloe vera (L.), Ruta graveolens (L.), Pfaffia glomerata (Spreng) Pedersen, and Chenopodium ambrosioides (L.) exhibited direct activity against extracellular forms of Leishmania.…”

Section: Treatmentmentioning

confidence: 99%

Recent updates and perspectives on leishmaniasis

Savoia

2015

J Infect Dev Ctries

146

128

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Leishmaniasis is a neglected vector-borne tropical infection considered to be a disease of the poor. Concentrated in poverty-stricken countries within Southeast Asia, East Africa, and Latin America, it is also endemic in several Mediterranean countries. The management of the heterogeneous syndromes determined by parasites belonging to the genus Leishmania is particularly difficult in developed, non-endemic countries owing to the unfamiliarity of physicians with clinical symptoms, diagnostic possibilities, and available treatment options. Therefore, travelers and other people who may be exposed to sand flies in endemic areas should receive counseling regarding leishmaniasis and appropriate protective measures. Serological diagnosis is rarely used for cutaneous and mucocutaneous diseases, but it is the most commonly used technique for visceral leishmaniasis. The drugs used to treat this last disease are expensive and sometimes have toxic side effects. This review highlights the diagnostic, chemotherapeutic, and immunizing strategies to control leishmaniasis, though no human vaccine is commercially available currently owing to the complexity of the cellular immune response to this parasite.

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Section: Treatmentmentioning

confidence: 99%

Recent updates and perspectives on leishmaniasis

Savoia

2015

J Infect Dev Ctries

146

128

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“…Leishmania is an obligatory intracellular protozoan that has two stages during its life cycle: promastigote that develops in the midgut of sand fly (as a vector) and culture medium, and amastigote that multiplies in the host macrophage (1,2). Leishmania is transmitted by the bite of the female sandfly.…”

Section: Introductionmentioning

confidence: 99%

“…Different clinical manifestations of leishmaniasis include Cutaneous Leishmaniasis (CL), Mucocutaneous Leishmaniasis (MCL), and Visceral Leishmaniasis (VL) (1,3). Cutaneous leishmaniasis is endemic in different parts of the world, particularly in the Middle East (Afghanistan, Algeria, Iraq, Yemen, Saudi Arabia, and Iran) (1,(3)(4)(5). The topical treatment of CL includes the use of pentavalent antimony compounds such as sodium stibogluconate and meglumine antimoniate; but unfortunately, these drugs are not effective for the treatment of CL (4).…”

Section: Introductionmentioning

confidence: 99%

“…The topical treatment of CL includes the use of pentavalent antimony compounds such as sodium stibogluconate and meglumine antimoniate; but unfortunately, these drugs are not effective for the treatment of CL (4). Meanwhile, they are toxic, expensive, painful, and associated with adverse side effects, drug resistance, relapse after treatment, and without satisfactory results (1,3,5).…”

Section: Introductionmentioning

confidence: 99%

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Antileishmanial Effects of Propolis Against Leishmania major In Vitro and In Vivo

Tavakoli

Shaddel

Yakhchali

et al. 2020

Ann Mil Health Sci Res

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Background: Propolis is produced by honey bees from plants, buds, and exudates and as an antiseptic is used to treat several diseases, such as acne and wounds. Objectives: Due to some difficulty in the treatment of cutaneous leishmaniasis, the aim of this study was to evaluate the propolis extract function against Leishmania major.Methods: Different concentrations (9.375, 18.75, 37.5, 75, 150, and 300 µg/mL) of both Ethanolic Extract of Propolis (EEP) and the standard drug (Glucantime) were prepared for the in vitro model, and then applied to the fixed number of promastigotes. The promastigotes were counted after 24, 48, and 72-h treatment. Then, the viability of promastigotes was tested by MTT after 72 h of treatment. Twenty mice with cutaneous leishmaniasis were divided into four groups for in vivo model, including a positive group (treatment with Glucantime), a negative group (without treatment), and two experimental groups (treatment with EEP 1% and 4%). The sizes of the ulcers were measured at the beginning of the experiment and weekly for four weeks. Results: The in vitro model indicated that both EEP and Glucantime reduced the number of promastigotes and the difference between EEP and Glucantime was not significant at concentrations 37.5, 75, 150, and 300 µg/mL. The in vivo model demonstrated that EEP 4% and Glucantime were similar and decreased the size of ulcers more significantly than the negative control and EEP 1% (P < 0.05). Conclusions: Propolis as an herbal drug had antileishmanial activity against Leishmania major in vitro and in vivo. We suggest using it for complementary treatment.

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“…The Brazilian ginseng is used for restoring vital functions, increasing physical strength and mental equilibrium, and protecting the gastric mucosa from injury. It is also used for the treatment of diabetes and rheumatism, and it possesses antioxidant, analgesic, anti-inflammatory, trypanocidal, antileishmanial, and aphrodisiac actions (De Oliveira, 1986;Neto et al, 2004;Queiroz et al, 2014).…”

Section: Introductionmentioning

confidence: 99%