Antileishmanial activity of Opuntia ficus-indica fractions

Bargougui, Ahlem; Champy, Pierre; Triki, Saïda; Bories, C.; Pape, Patrice Le; Loiseau, Philippe M.

doi:10.1016/j.bionut.2013.09.001

Cited by 8 publications

(3 citation statements)

References 10 publications

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“…The bioassay-guided fractionation technique has been employed by many researchers to study natural products (Baldé et al, 2010;Bargougui et al, 2014;Campos, Azevedo, Filho, Perez, & Braga, 2013;Ding, Ding, Zhang, & Luo, 2013;Oldoni et al, 2011;Teke et al, 2011). The main reason to choose this technique is the rationalization process used to isolate biologically active substances from complex natural extracts.…”

Section: Introductionmentioning

confidence: 99%

Bioassay-guided isolation of proanthocyanidins with antioxidant activity from peanut (Arachis hypogaea) skin by combination of chromatography techniques

et al. 2016

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Purification and bioassay-guided fractionation were employed to isolate proanthocyanidins with antioxidant activity from peanut skin (Arachis hypogaea Runner 886). The crude extract was prepared with acetone (60% v/v) and purified using chromatographic methods, including a semipreparative HPLC technique. As a result, two proanthocyanidins were isolated and identified using NMR, epicatechin-(2 β → O → 7, 4 β → 8)-catechin (proanthocyanidin A1) and epicatechin-(β → 2 O → 7, 4 β → 8)-epicatechin (proanthocyanidin A2). Despite the structural similarity, differences were observed in their antioxidant activity. Proanthocyanidin A1 proved to be more active, with EC50 value for DPPH radical scavenging of 18.25 μg/mL and reduction of Fe(3+)-TPTZ complex of 7.59 mmol/g, higher than that of synthetic antioxidant BHT. This compound evaluated by ABTS(+) was similar to that of natural quercetin. Therefore, peanut skin is an important source of bioactive compounds that may be used as a mild antioxidant for food preservation.

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Section: Introductionmentioning

confidence: 99%

Bioassay-guided isolation of proanthocyanidins with antioxidant activity from peanut (Arachis hypogaea) skin by combination of chromatography techniques

et al. 2016

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“…The results showed that Opuntia ficus indica cladodes/fruits ectract exhibited an activity against Leishmania major and Leishmania donovani as well as a poor activity against Trypanosoma brucei. 32 The study concluded that caffeic acid and α-sitosterol have antileishmanial and anti-trypanosomal activities. A study carried out in Algeria, 2017 concluded that caffeic acid and quercetin have leishmanicidal effect and both are a potential therapeutic role against cutaneous leishmaniasis.…”

Section: Antileishmanial Property Of Opuntia Ficus-indicamentioning

confidence: 99%

Present and Future Potential of Antiparasitic Activity of Opuntia ficus-indica

2020

TJNPR

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One of the most important plant that has received greatattention in recent years, especially in arid and semi-arid areas, is prickly pear cactus (Opuntia ficus indica) due to its tolerance of drought, high temperatures and poor soils. Opuntia ficus-indica is a bushy or erect and tree-like perennial succulent with a definite woody trunk, with a large top. 1 It is characterized by being fast growing and its edible fruits are harvested 3 years after planting. 1 Fruits are ovoid to oblong with sometimes spines, normally red to purplish, green, yellow or orange, fleshy, juicy, edible, able to storage for several months. The pulp may be white-yellowish, orangish or purple-red. It is native to Mexico, but now cultivates in the rural areas of the many countries, where plants play an important role in the economic life of rural residents as a source of food for humans (consuming both the fruits and pad), beverages, and livestock fodder, soap, drinking water purification and as a protective hedge for fencing, 2,3 also dye as host plants for the cochineal insect (Dactylopius coccus). Cochineals are used to make carmine dye, a highly prized red dye for textiles. 4 Historically, the prickly pear has been used in traditional medicine to treat digestive problems, anemia, ulcers, bronchitis, edema, urinary problems, fever, inflammation, vitiligo, and for burn and wound care. Also, it has been used as a diuretic, treatment of liver problems, hemorrhoids, bladder stones, inflammation of the eyes, lower back pain, spleen enlargement, and management of human immunodeficiency virus (HIV) and tumors. 2,3,5 Among the traditional uses of pads/cladodes are to relieve heat and inflammation, and wound care., while flowers are used for treatment of lung problems, including bronchitis and asthma, and also fruits are used to treat gonorrhea and

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“…23 Literature review shows that bioassay-guided fractionation is one of the methods utilized by researchers to examine and isolate pharmacologically active compounds from their natural source. [26][27][28][29][30][31][32] This is a stepwise and thorough process that guides the researcher to screen and isolate bioactive compound from natural source and also ensure that the activity of the compound is not lost in the process due to contamination as the compounds or extracts is intermittently screened in the process for their bioactivity. Terminalia microptera belong to the family Combretaceae also known as "Orin idi odan" among the Yoruba people in the South Western part of Nigeria.…”

Section: Introductionmentioning

confidence: 99%

Toxicological, Bioassay-Guided Fractionation and Antibacterial Activity of Methanol Stem Extract of Terminalia microptera on Oral Bacteria Pathogens

2021

TJNPR

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currently available drugs contain phytochemicals as their active components. 1 The greater part of the human ailments resulting from bacterial infections, protozoans, and parasitic diseases, disorder from metabolic complications and sickness related with oxidative stress have been overseen appropriately using medicinal plants. 6-10 The development of multi-drug resistance in pathogenic microorganisms and parasites to different anti-infection agents and non-accessibility of safe antimicrobial agents for treatment has prompted a search for other antimicrobial agents from different sources with special interest on plants that might be utilized for the production of new drugs. 11-12 The vast majority of the natural products, basically of plant origin, have been screened to assess their antimicrobial activities on oral microorganisms. 13-19 Different oral hygiene methods have been used to overcome widely endemic diseases such as dental caries and oral infections. Due to Increasing awareness and expected evolving population; the use of safe, effective and economical products such as medicinal plant has expanded drastically. 20 Studies have shown that plant and herbal extracts possess significant antimicrobial potential against oral bacteria. As a result, several toothpaste and mouth rinses contain these herbal components to aid the conventional toothpaste. However only a limited amount of published data exists regarding the efficacy of these products on the initial plaque forming bacteria. 21 There exists a unique balance between the microbiota and the host in the oral cavity. Any

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Antileishmanial activity of Opuntia ficus-indica fractions

Cited by 8 publications

References 10 publications

Bioassay-guided isolation of proanthocyanidins with antioxidant activity from peanut (Arachis hypogaea) skin by combination of chromatography techniques

Bioassay-guided isolation of proanthocyanidins with antioxidant activity from peanut (Arachis hypogaea) skin by combination of chromatography techniques

Present and Future Potential of Antiparasitic Activity of Opuntia ficus-indica

Toxicological, Bioassay-Guided Fractionation and Antibacterial Activity of Methanol Stem Extract of Terminalia microptera on Oral Bacteria Pathogens

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