Antileishmanial and antioxidant potential of fractions and isolated compounds from <i>Nectandra cuspidata</i>

Ferreira, Lilian dos Anjos Oliveira; Oliveira, Mariana Maciel de; Faleiro, Flávia Lais; Scariot, Débora B.; Boeing, Joana Schuelter; Visentainer, Jesuí Vergílio; Romagnolo, Mariza Barion; Nakamura, Celso Vataru; Truiti, Maria da Conceição Torrado

doi:10.1080/14786419.2017.1378214

Cited by 9 publications

(6 citation statements)

References 12 publications

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“…Other authors report the antioxidant potential for species of the genus. Ferreira et al (2018) found high activity for Nectandra cuspidata leaves with a IC50 of 6.54 ± 0.10 µg.mL -1 . In studies on Nectandra grandiflora, Silva et al (2018) observed inhibition of about 80% of the DPPH • radical.…”

Section: Resultsmentioning

confidence: 92%

Bioactive compounds contents of and antioxidant activity of Nectan-dra megapotamica (Lauraceae)

Damião,

Gomes,

Da Silva

2023

OLEL

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Nectandra megapotamica (Spreng.) Mez., Lauraceae known as cinnamon, is a species native to Brazil, widely used in folk medicine. The present project aimed to evaluate the antioxidant activity and determine the contents of phenols, flavonoids, tannins, and total alkaloids in extracts from the leaves and bark of a specimen of N. megapotamica that occurs in the southern region of the state of Mato Grosso do Sul. Crude ethanolic extracts obtained from leaves and bark were tested for antioxidant activity by DPPH and ABTS methods and dosage of phenols, flavonoids, tannins, and total alkaloids by spectrophotometry in the visible region. The extracts exhibited considerable antioxidant activity, particularly the leaf extract was the most active in both methods, yielding IC50 of 9.0 ± 0.18 and 14.29 ± 0.16 μg.mL-1, respectively. This extract showed higher levels of phenols, flavonoids, tannins, and total alkaloids. The results suggest that the antioxidant activity is related to the presence of phenolic compounds and alkaloids, known antioxidant compounds, quantified in this study.

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Section: Resultsmentioning

confidence: 92%

Bioactive compounds contents of and antioxidant activity of Nectan-dra megapotamica (Lauraceae)

Damião,

Gomes,

Da Silva

2023

OLEL

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“…amazonum [ 41 ], N . cissiflora [ 42 ], vitexin, isovitexin, and epicatechin in Nectandra cuspidata [ 43 ] and quercetin-3- O -rhamnoside in Nectandra grandiflora [ 44 ]. Thus, the other compounds of the Nectandra genus identified herein (peak 1, 3, 4, 5, 6, 7, 9, 10, 11, 13, 14, 15, 16, 18, 21, 22 and 23 ) are described for the first time, demonstrating the capacity of N .…”

Section: Resultsmentioning

confidence: 99%

In depth investigation of the metabolism of Nectandra megapotamica chemotypes

et al. 2018

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Plants produce a wide range of secondary metabolites. Within a single species, chemotypes can be distinguished by the differences in the composition of the secondary metabolites. Herein, we evaluated Nectandra megapotamica (Spreng.) chemotypes and the balance of different classes of metabolites to verify how significant differences in plant metabolism are regarding chemotypes. We collected N. megapotamica leaves from eight adult plants in two Brazilian states. The essential oils and ethanol/water extracts were analyzed by GC-MS and LC-DAD-MS, respectively. Histochemical tests were performed, as well as chemical analyses of leaves from adaxial and abaxial foliar surfaces of N. megapotamica, and the stereochemistry of α-bisabolol was determined. Two different chemotypes, based on volatile compounds, were identified, distinguished by the presence of isospathulenol, α-bisabolol, β-bisabolene, and (E)-nerolidol for chemotype A, and bicyclogermacrene and elemicin for chemotype B. A stereochemical analysis of chemotype A extract revealed (+)-α-bisabolol enantiomer. Histochemical tests of chemotypes showed similar results and suggested the presence of essential oil in idioblasts stained with the dye NADI. The analyses of chemotype A leaves by GC-MS revealed similar compositions for abaxial and adaxial surfaces, such pattern was also observed for chemotype B. Medium and high polarity metabolites showed high chemical similarities between the chemotypes, highlighting the presence of proanthocyanidins and glycosylated flavonoids (O- and C-glycosides). Thus, N. megapotamica produced distinct volatile chemotypes with highly conserved medium to high polarity compounds. Such results suggest that phenolic derivatives have a basal physiological function, while genetic or environmental differences lead to differentiation in volatile profiles of N. megapotamica.

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“…Although not effective in Leishmania parasites, the NMR spectra of J. gossypifolia extracts were analyzed suggesting the occurrence of flavonoids. Recently, the leishmanicidal activity of the flavonoids isovitexin and vitexin was analyzed against promastigote and amastigote forms of L. (L.) donovani and L. (L.) amazonensis , being more effective against the visceral than the cutaneous counterpart [54, 55]. Furthermore, orientin-containing fraction from Cecropia pachystachya altered L. (L.) amazonensis viability by interfering in the mitochondrial-kinetoplast complex and inhibiting parasite arginase enzyme [56].…”

Section: Discussionmentioning

confidence: 99%

Ethnopharmacology Study of Plants from Atlantic Forest with Leishmanicidal Activity

Santos

Bezerra-Souza

Aragaki

et al. 2019

Evidence-Based Complementary and Alternative Medicine

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Leishmaniasis is an infectious disease caused by a protozoan belonging to Leishmania genus. Different clinical outcomes can be observed depending on the parasite species and patient’s health condition. The outcomes can range from single cutaneous lesions to lethal visceral form. The treatment of all forms of leishmaniasis is based on pentavalent antimonials, and, in some cases, the second-line drug, amphotericin B, is used. Beside the toxicity of both classes of drugs, in some areas of the world, parasites are resistant to antimonial. These detrimental features make fundamental the discovery and characterization of new drugs or plant extracts with leishmanicidal effects. Brazil is a well-known country for its biodiversity. Additionally, the common knowledge inherited for generations in small villages makes Brazil a source of new information and resources for the discovery and development of new drugs. Based on ethnopharmacology, elderlies were interviewed about plants they commonly used for skin diseases and infections. Five native plants from Atlantic forest were indicated; EtOH and n-hexane extracts were prepared with the vegetative organs of the plants and assayed against promastigote and amastigote forms of L. (L.) amazonensis. The major molecules of each extract were detected using qualitative nuclear magnetic resonance. Among all tested extracts, the n-hexane extract from the leave of Eugenia uniflora (Myrtaceae), enriched in myricitrin and quercitrin flavonoids, was the most effective against L. (L.) amazonensis amastigotes. This data supports the ethnopharmacology approach as a successful tool for the discovery of new drugs with leishmanicidal effects.

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Antileishmanial and antioxidant potential of fractions and isolated compounds from Nectandra cuspidata

Cited by 9 publications

References 12 publications

Bioactive compounds contents of and antioxidant activity of Nectan-dra megapotamica (Lauraceae)

Bioactive compounds contents of and antioxidant activity of Nectan-dra megapotamica (Lauraceae)

In depth investigation of the metabolism of Nectandra megapotamica chemotypes

Ethnopharmacology Study of Plants from Atlantic Forest with Leishmanicidal Activity

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