Antileishmanial, Antimicrobial and Antifungal Activities of Some New Aryl Azomethines

Abstract

A series of eighteen azomethines has been synthesized by the reaction of appropriate primary aromatic amines with aryl and/or heteroaryl carboxaldehydes. The synthesized azomethines have been evaluated for their in vitro antileishmanial, antibacterial and antifungal activities. The results revealed some antifungal activity of most of the synthesized compounds, whereas the antileishmaniasis activity results highlighted that all synthesized azomethines inhibited parasite growth and most of them showed highly potent action towards Leishmania major promastigotes. No remarkable bactericidal activities were observed.

Synthesis, Characterization, and Antibacterial Activities of Some New Zinc Coordination Compounds of an Asymmetric Bidentate Schiff Base

“…A doublet signal at 1.29 ppm with coupling constant of 5.4 Hz was assigned to H ddʹ 13. C NMR spectrum of the ligand showed two iminic carbons at 164.80 and 162.84 ppm confirming asymmetric structure of it [37,38]. Other carbons were appeared at 150.96, 150.94, 142.37, 142.25, 130.52, 128.61, 123.96, 123.92, 112.04, and 111.98 for aromatic and olefinic carbons, at 68.14, 66.24 ppm for ethylenic carbons and 40.…”

“…Two doublet (d) signals at 8.01 ppm and 7.95 ppm with coupling constants of 8.80 Hz are related to iminic protons (H ee '). [37,38] 25, 20.75 ppm for N-methyl carbons and methyl(amine chain). After coordination, the 1 H NMR spectrum of ligand has faced to some changes such as chemical shifts as observable in experimental section and/or differences in outward models of hydrogens.…”

Design, Synthesis, and In Vitro Antileishmanial and Antitumor Activities of New Tetrahydroquinolines

“…All the synthesized heterocyclic compounds were initially screened for their antileishmanial activity in contrast to culture of L. major .…”

Facile synthesis of new fused and non-fused heterocyclic systems from a γ-ketoacid

“…In continuation of our previous works [11][12][13][14][15][16][17][18][19], the present work aimed at utilization of the reactivity of 4-(2-tetryl)-4-oxobut-2-enoic acid (1) towards different nucleophiles such as carbon, nitrogen, oxygen, sulfur nucleophiles and binucleophiles (o-phenylenediamine, o-aminophenol, and o-aminothiophenol) to construct mixed and non-mixed heterocyclic systems. Several electrophilic centers are present in acid (1) (α,β-unsaturated-γ-ketoacid), viz atoms C(2) and C(4) which are hopeful for many reaction routes with nucleophilic reagents.…”