Antileishymanicidal acvity of Gochnatia pulchra

Lucarini, Rodrigo; Salloum, Aio; Rezende, Kcs; Esperandim, VR; Ferreira, DS; Magalhães, LG; Silva, Mla e; Cunha, WR; Vinholis, Ahc; Martins, C. S. A.

doi:10.1055/s-0032-1321103

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“…Finally, it is important to highlight that those studies without data on the isolation/chemical composition of the extracts or their effects in vivo were not included in this manuscript. Examples of these studies are: Calendula officinalis L. against L. major promastigotes and amastigotes (Nikmehr et al, 2014); Echinacea purpurea (L.) Moench against L. donovani promastigotes (Canlas et al, 2010) and L. major in in vivo infection (Sarkari et al, 2017); Echinops kebericho Mesfin toward L. aethiopica and L. donovani promastigotes and amastigotes (Tariku et al, 2011); Gochnatia pulchra Cabrera against L. amazonensis (Lucarini et al, 2012, 2016); Waldheimia tomentosa (Decne.) Regel against L. major promastigotes and amastigotes (Bhatnagar et al, 2017); and Pulicaria gnaphalodes (Vent.)…”

Section: Other Compounds From Asteraceae Plants With Activity Againstmentioning

confidence: 99%

Asteraceae Plants as Sources of Compounds Against Leishmaniasis and Chagas Disease

et al. 2019

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Leishmaniasis and Chagas disease cause great impact on social and economic aspects of people living in developing countries. The treatments for these diseases are based on the same regimen for over 40 years, thus, there is an urgent need for the development of new drugs. In this scenario, Asteraceae plants (a family widely used in folk medicine worldwide) are emerging as an interesting source for new trypanocidal and leishmanicidal compounds. Herein, we provide a non-exhaustive review about the activity of plant-derived products from Asteraceae with inhibitory action toward Leishmania spp. and T. cruzi . Special attention was given to those studies aiming the isolation (or identification) of the bioactive compounds. Ferulic acid, rosmarinic acid, and ursolic acid ( Baccharis uncinella DC.) were efficient to treat experimental leishmaniasis; while deoxymikanolide ( Mikania micrantha ) and (+)-15-hydroxy-labd-7-en-17-al ( Aristeguietia glutinosa Lam.) showed in vivo anti- T. cruzi action. It is also important to highlight that several plant-derived products (compounds, essential oils) from Artemisia plants have shown high inhibitory potential against Leishmania spp., such as artemisinin and its derivatives. In summary, these compounds may help the development of new effective agents against these neglected diseases.

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