Antilithiatic effect of Asparagus racemosus willd on ethylene glycol induced lithiasis in male albino Wistar rats

Abstract

The ethanolic extract of Asparagus racemosus Willd. was evaluated for its inhibitory potential on lithiasis (stone formation), induced by oral administration of 0.75% ethylene glycolated water to adult male albino Wistar rats for 28 days. The ionic chemistry of urine was altered by ethylene glycol, which elevated the urinary concentration of crucial ions viz. calcium, oxalate, and phosphate, thereby contributing to renal stone formation. The ethanolic extract, however, significantly (p < 0.05) reduced the elevated level of these ions in urine. Also, it elevated the urinary concentration of magnesium, which is considered as one of the inhibitors of crystallization. The high serum creatinine level observed in ethylene glycol-treated rats was also reduced, following treatment with the extract. The histopathological findings also showed signs of improvement after treatment with the extract. All these observations provided the basis for the conclusion that this plant extract inhibits stone formation induced by ethylene glycol treatment.

Dietary Plants for the Prevention and Management of Kidney Stones: Preclinical and Clinical Evidence and Molecular Mechanisms

“…[ 94 ], Ageratum conyzoides (L.) L. [ 11 ], Alcea rosea L. [ 95 ], Asparagus racemosus Willd. [ 96 ], Bombax ceiba L. [ 97 ], Carthamus tinctorius L. [ 98 ], Cynodon dactylon (L.) Pers. [ 99 ], Helichrysum graveolens (M.…”

Documentation and quantitative analysis of the local knowledge on medicinal plants among traditional Siddha healers in Virudhunagar district of Tamil Nadu, India

“…This caused a high consensus for the medicinal plants that were prescribed as adjuvants. In urinary ailments group, the plants such as Tribulus terrestris (Aggarwal et al, 2010), Musa paradisiaca (Patnakar et al, 2008), Aerva lanata (Soundararajan et al, 2006), Asparagus racemosus (Christina et al, 2005) and Pedalium murex (Thamizhmozhi et al, 2009) were having pharmacological support.…”

Medicinal Properties of Selected Asparagus Species: A Review

“…against member damage induced by the free radicals generated during gamma radiation [86,95]. It also raised the urinary concentration of magnesium, which is considered as one of the suppressors of crystallization [96]. Aqueous and butanol fractions displayed less prominent effects on the release of, especially at lower glucose concentration [97].…”