“…Analogues of purines have been identified as lead compounds for therapy against a number of diseases (Adachi, Motomatsu, & Yara, 1979;Alvarez, Lee, & Abel-Santos;Cairo & Bishop, 2004;Cassera, Zhang, Hazleton, & Schramm, 2011;Cunico et al, 2006;Hosaka, Suzuki, & Kumada, 2011;Keough et al, 2006;Ogilvie et al, 1984;Yang et al, 2010). Purine base analogues can also be used to identify interactions of individual functional groups in the natural substrate in the protein complex.…”