Antimalarial activity of extracts and fractions from Bidens pilosa and other Bidens species (Asteraceae) correlated with the presence of acetylene and flavonoid compounds

Brandão, Maria G.L.; Krettli, Antoniana U.; Soares, L.S.R; Nery, C.G.C; Marinuzzi, H.C

doi:10.1016/s0378-8741(97)00060-3

Cited by 171 publications

(129 citation statements)

References 15 publications

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“…When considering the phytochemical composition of the different plants extracts of B. pilosa extracts, all are composed of common chemicals such as phenylheptatryine, quercetin, ferulic acid, caffeic acid, flavone glycosides, and minerals. These compounds have been reported to acts severally and/or jointly on the biological activity of plant extracts (Brandao et al, 1997;Lic. Humberto et al, 2001).…”

Section: Discussionmentioning

confidence: 99%

“…The liquid obtained was freeze-dried giving 38g of a brownish powder. A stock solution of 100mg/ml in distilled water was prepared daily because of the high instability of B. pilosa's components (Brandao et al, 1997). The ethanol extract was prepared by macerating 200g of sun dried leaves for three days in one litre of ethanol (95% purity).…”

Section: Collection and Preparation Of Aqueous And Ethanol Extractsmentioning

confidence: 99%

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In vivo and in vitro effects of Bidens pilosa l. (asteraceae) leaf aqueous and ethanol extracts on primed-oestrogenized rat uterine muscle.

Longo

Rakotonirina

Rakotonirina³

et al. 2008

Afr. J. Trad. Compl. Alt. Med.

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Bidens pilosa L. is an Asteraceae growing in tropical zones, and traditionally utilized worldwide in herbal medicine. The present work is based on its traditional use during child birth as a labour facilitator. In vivo tests of acute toxicity showed a weak toxic effect for both extracts but the toxicity of the ethanol extract (LD 50 =6.15g/kg) was upper than that of the aqueous extract (LD 50 =12.30g/kg). The three-days uterotrophic assay on immature mice showed body weight gain followed by a concentration-dependent decrease up to 4mg/g and a concentration dependent uterine wet weight increase. The ethanol extract exhibited the higher body weight gain representing 22.8±0.7%, (P≤0.001), at the concentration of 500µg/g/day, while the aqueous extract was significantly more efficient on the uterine wet weight gain of 0.24±0.001% (P≤0.05), at the concentration of 1000µg/g/day. In vitro isometric contraction measurement of oestrogen-primed rat uterine strips showed a significant high aqueous extract-induced contractile effect from 0.03-1.97mg/ml: on the amplitude of contraction (EC 50 = 0.44±0.10mg/ml, P≤0.05), and on the rate (1.21±0.25mg/ml, P>0.05). Inspite of the higher effect of the aqueous extract on the tonus (57.23±23%), the ethanol extract showed a high effect (EC 50 = 0.34±0.09mg/ml, P≤0.05). The weak toxicity, the estrogenic-like and the oxytocic-like activities observed could explain the empirical use of Bidens pilosa leaf aqueous extract as an uterotonic preparation to enhance labour, probably due to the presence of biologically active compound(s) which act directly on the uterine muscle.

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Section: Discussionmentioning

confidence: 99%

Section: Collection and Preparation Of Aqueous And Ethanol Extractsmentioning

confidence: 99%

In vivo and in vitro effects of Bidens pilosa l. (asteraceae) leaf aqueous and ethanol extracts on primed-oestrogenized rat uterine muscle.

Longo

Rakotonirina

Rakotonirina³

et al. 2008

Afr. J. Trad. Compl. Alt. Med.

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“…Extracts of Bidens pilosa, another medicinal plant that has been used against fevers in general, are active against malaria parasites in vivo and in vitro; flavonoids and polyacetylenes present in this and several other Bidens spp have proven to be active (Brandão et al 1997, AndradeNeto et al 2004). Interestingly, B. pilosa was validated for human use by the Ministry of Health in Brazil (portal.…”

Section: Strategies Used To Discover New Antimalarial Drugs -A Searchmentioning

confidence: 99%

“…Approximately 50% of other species of medicinal plants that are commonly used in Brazil have a demonstrated activity against malaria parasites , Brandão et al 1997, Andrade-Neto et al 2007). These results affected our research on plants.…”

Section: Strategies Used To Discover New Antimalarial Drugs -A Searchmentioning

confidence: 99%

New approaches in antimalarial drug discovery and development: a review

Aguiar

Rocha

Souza

et al. 2012

Mem. Inst. Oswaldo Cruz

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Malaria remains a major world health problem following the emergence and spread of Plasmodium falciparum that is resistant to the majority of antimalarial drugs. This problem has since been aggravated by a decreased sensitivity of Plasmodium vivax to chloroquine. This review discusses strategies for evaluating the antimalarial activity of new compounds in vitro and in animal models ranging from conventional tests to the latest high-throughput screening technologies. Antimalarial discovery approaches include the following: the discovery of antimalarials from natural sources, chemical modifications of existing antimalarials, the development of hybrid compounds, testing of commercially available drugs that have been approved for human use for other diseases and molecular modelling using virtual screening technology and docking. Using these approaches, thousands of new drugs with known molecular specificity and active against P. falciparum have been selected. The inhibition of haemozoin formation in vitro, an indirect test that does not require P. falciparum cultures, has been described and this test is believed to improve antimalarial drug discovery. Clinical trials conducted with new funds from international agencies and the participation of several industries committed to the eradication of malaria should accelerate the discovery of drugs that are as effective as artemisinin derivatives, thus providing new hope for the control of malaria

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“…Crude ethanolic extracts of each of 5 locally used antifungal plant remedies were non-sequentially extracted as earlier described [10]; this was tested for activity against dermatophyte isolates, as follows: stock solution of the crude extract was made in 1:9 dilution of dimethyl sulphoxide (DMSO) in water; this was serially diluted in distilled water [11]. Dilutions of ketoconazole were similarly made.…”

Section: Methodsmentioning

confidence: 99%

Ringworm Infections in Anambra State of Nigeria: Epidemiologic Features and Antifungal Potentials of Local Plant Remedies

Emele¹,

Ca²

2017

Hair Ther Transplant

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Ringworm infection remains an important public health problem in Nigeria, as in other parts of the world where poor living conditions prevail. The epidemiologic pattern of the disease has not been well defined in Anambra State of Nigeria, hence the need for this study. A total of 51,092 individuals (48,084 children and 3,008 adults) were surveyed for ringworm lesions. The population constituted of primary school children and their contacts. Results showed that of the 51,092 individuals, 5,127 (or 10.04%) had ringworm lesions on their body. Scalp ringworm was more common in children than adults (X 2 =9.8482; P<0.05). Younger children were more frequently affected than older children, who, in turn, were more affected than adults. Although scalp infection was significantly more common in children, ringworm of other body parts did not show significant age (X 2 =0.0297; P>0.05) or gender-related (X 2 =0.0057; P>0.05) pattern. Contact tracing showed that chances of transmitting ringworm infection from a case were higher in the family (38%) than in the school classroom (1.3%), which was higher than in the neighbourhood (0.8%). Transmission within the household was mainly horizontal among children, and occasionally from child to adults. Close and prolonged contacts with ringworm-afflicted individual appeared to enhance transmission. Of plant materials locally used to treat ringworm infections, the inhibitory concentrations against locally isolated dermatophyte fungi were as follows: leaves of Vanda roxburgii (MIC range =1.56-25.00 mg/ml; MIC 90 =25.00 mg/ml), Parkia biglobosa seeds (MIC range =3.13-12.50 mg/ml; MIC 90 =12.50 mg/ml), leaves of Sena alata (MIC range =3.13-12.50 mg/ml; MIC 90 =12.50 mg/ml), leaves of Mitracarpus villosus (MIC range =3.13-25.00 mg/ml; MIC 90 =25.00 mg/ml) and Gmelina arborea fruits (MIC range =6.25-100 mg/ml; MIC 90 =50.00 mg/ml). It could be concluded that tropical plants hold great promise as potential source of antifungal agents and are therefore, recommendable as possible option in the search for newer anti-fungal agents.

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Antimalarial activity of extracts and fractions from Bidens pilosa and other Bidens species (Asteraceae) correlated with the presence of acetylene and flavonoid compounds

Cited by 171 publications

References 15 publications

<i>In vivo</i> and <i>in vitro</i> effects of <i>Bidens pilosa</i> l. (asteraceae) leaf aqueous and ethanol extracts on primed-oestrogenized rat uterine muscle.

<i>In vivo</i> and <i>in vitro</i> effects of <i>Bidens pilosa</i> l. (asteraceae) leaf aqueous and ethanol extracts on primed-oestrogenized rat uterine muscle.

New approaches in antimalarial drug discovery and development: a review

Ringworm Infections in Anambra State of Nigeria: Epidemiologic Features and Antifungal Potentials of Local Plant Remedies

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