Antimalarial activity of fractions of aqueous extract of Acacia nilotica root

Alli, Lukman A.; Adesokan, AA; Salawu, Adeola Oluwakanyinsola

doi:10.5455/jice.20160331064817

Cited by 38 publications

(45 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this study, all test groups treated with methanol, aqueous and chloroform crude extracts of B. antidesenterica induced more than 30 % suppression including the lower doses except the 200 mg/kg of the aqueous extract. Similar studies on other plant species such as Acacia nilotica [25], Clerodendrum myricoides, Dodonea angustifolia and Aloe debrana [26] and A. africanus [27] reported significant parasitaemia suppression.…”

Section: Discussionsupporting

confidence: 70%

Antimalarial properties of crude extracts of seeds of Brucea antidysenterica and leaves of Ocimum lamiifolium

Kefe

Giday

Mamo

et al. 2016

BMC Complement Altern Med

View full text Add to dashboard Cite

BackgroundThe search for new antimalarial drugs has become increasingly urgent due to plasmodial resistance to existing drugs. As part of this global effort, the present study aimed at evaluating the antimalarial activity of two traditionally used medicinal plants against the disease.MethodsAcute toxicity and four-day suppressive effects of aqueous, methanol and chloroform extracts of the seed and leaf of Brucea antidysenterica and Ocimum lamiifolium, respectively, were investigated in Swiss albino mice using Plasmodium berghei using standard procedures.ResultsMethanol extract of the leaves of O. lamiifolium did not exhibit any sign of acute toxicity up to the dose of 2000 mg/kg body weight. However, all mice provided with seeds of B. antidesenterica at a dose of 2000 mg/kg body died within 24 h. The aqueous, methanol and chloroform crude extracts of B. antidesenterica significantly (p < 0.05) inhibited parasitaemia in a dose-dependent manner and prevented body weight loss at doses of 200, 400 and 600 mg/kg body weight. In addition, the extracts prolonged the mean survival time of P. berghei-infected mice compared to the non-treated control. However, it did not prevent reduction in packed cell volume except the chloroform extract in three doses and methanol extract at 200 mg/kg and 400 mg/kg. Extracts from O. lamiifolium also exhibited significant (p < 0.05) antiplasmodial activities. The extracts did not prevent body weight loss and PCV reduction, especially in chloroform. The highest suppression was recorded from aqueous crude extract of O. lamiifolium with 35.53 % in the dose of 600 mg/kg. On the other hand, a similar higher suppression was found in both methanol and chloroform of crude extracts of B. antidesenterica with 47.70 %, 46.44 % of chemosuppression, respectively, in its highest dose tested.ConclusionCrude aqueous, methanol and chloroform extracts of the two medicinal plants possess acceptable antimalarial effects. However, further investigation should be pursued on toxicity study and to isolate the bioactive components responsible for the observed antimalarial action of the plants.

show abstract

Section: Discussionsupporting

confidence: 70%

Antimalarial properties of crude extracts of seeds of Brucea antidysenterica and leaves of Ocimum lamiifolium

Kefe

Giday

Mamo

et al. 2016

BMC Complement Altern Med

View full text Add to dashboard Cite

show abstract

“…The plant extract was found to exhibit antidiarrhoeal, antibacterial, antimalarial and inhibition of lipid peroxidation [34-35-36]. Moreover, the results obtained in this study are similar to studies carried out for antiplasmodial activity in mice by Alli et al [37]. antimalarial activity against CQ sensitive (3D7) and CQ-resistant (Dd2 and INDO) strains of P. falciparum in culture using the fluorescence-based SYBR.…”

Section: In Vitro Anti-protozoal Activities Of Medicinal Plantssupporting

confidence: 78%

<i>In Vitro</i> Antiprotozoal Activities and Cytotoxicity of Selected Sudanese Medicinal Plants

Kabbashi¹,

Osman²,

Garbi³

et al. 2017

IJBECS

View full text Add to dashboard Cite

Abstract:Entamoeba histolytica is ranked third on the list of parasitic protozoan infections leading to death behind malaria and schistosomiasis. It is estimated also up to 200 millions of people are chronically infected with Giardia lamblia globally. Metronidazole is the drug currently widely used and recommended in the treatment of amoebiasis and giardiasis. However; sometimes it causes adverse effects such as myoplasia, neuralgia, allergic dermatitis, and others. The in vitro antiprotozoal activities of some selected Sudanese medicinal plants (Acacia nilotica subsp. nilotica, Adansonia digitata, Cyperus rotundus and Nigella sativa) were determined against Entamoeba histolytica and Giardia lamblia by employing the sub-culture method. The mammalian cytotoxicity of the investigated plants against normal Vero cell line was determined by applying MTT [(4, 5-dimethyl thiazol-2-yl)-2, 5-diphenyl tetrazolium bromide] method. All plants examined 100% inhibition at a concentration 500 µg/ml after 96 h; this was compared with Metronidazole which gave 95% inhibition at concentration 312.5 µg/ml at the same time against Entamoeba histolytica and Giardia lamblia. In addition, cytotoxicity (MTT-assay) of these plants against normal Vero cell line which verified the safety of the examined extracts with an IC 50 less 100 µg/ml. These studies prove the potent activity of extracts against E. histolyica and G. lamblia trophozoites in vitro with verified safety evidence for use.

show abstract

“…Saponins, flavonoids and tannins have been suggested to act as primary antioxidant or free radicals scavengers that can counteract the oxidative damage induced by the malaria parasite (29). However, the lack of oxidizing action in some plant does not rule out antiplasmodial activity since they may be active through other biochemical mechanisms (30). The presence of alkaloids in C. aurantifolia extract might have contributed to antiplasmodial activity exhibited by the plant extract.…”

Section: Discussionmentioning

confidence: 99%

Antiplasmodial activity of methanol leaf extract of Citrus aurantifolia (Christm) Swingle

Ettebong

Ubulom

Etuk

2019

J Herbmed Pharmacol

View full text Add to dashboard Cite

Introduction: Citrus aurantifolia (Christm) is a plant used for the treatment of various ailments including malaria. This study aimed to evaluate the in vivo antiplasmodial efficacy of methanol leaf extract of C. aurantifolia in Swiss albino mice. Methods: The median lethal dose (LD50) was determined by intraperitoneal administration of different doses of the extract (100–4000 mg/kg) to 6 groups of 3 mice each and the animals were observed for 24 hours for physical signs of toxicity. To evaluate the antiplasmodial activity of the extract, three models were used: suppressive, curative and repository. Doses of the extract used were 320, 640 and 960 mg/kg/d in mice, with Chloroquine (5 mg/kg/d) as standard drug. Pyrimethamine (1.2 mg/kg/d) was used as the standard drug for the repository test and distilled water (10 mL/kg/d) as control in all models. Results: In all models, the low dose (320 mg/kg) of the extract produced the highest chemosuppressive effects in all models (P < 0.001). Mice treated with extract lived longer than those in the control group (P < 0.001). Phytochemical screening revealed the presence of alkaloids, flavonoids, saponins, tannins and cardiac glycosides and the LD50 of 3280 mg/kg ± 0.01 shows that the extract has low toxicity. Conclusion: The result of this study shows that C. aurantifolia has antiplasmodial properties which support its use in ethnomedicine in the treatment of malaria.

show abstract

Antimalarial activity of fractions of aqueous extract of Acacia nilotica root

Cited by 38 publications

References 25 publications

Antimalarial properties of crude extracts of seeds of Brucea antidysenterica and leaves of Ocimum lamiifolium

Antimalarial properties of crude extracts of seeds of Brucea antidysenterica and leaves of Ocimum lamiifolium

<i>In Vitro</i> Antiprotozoal Activities and Cytotoxicity of Selected Sudanese Medicinal Plants

Antiplasmodial activity of methanol leaf extract of Citrus aurantifolia (Christm) Swingle

Contact Info

Product

Resources

About

Antimalarial activity of fractions of aqueous extract of Acacia nilotica root

Cited by 38 publications

References 25 publications

Antimalarial properties of crude extracts of seeds of Brucea antidysenterica and leaves of Ocimum lamiifolium

Antimalarial properties of crude extracts of seeds of Brucea antidysenterica and leaves of Ocimum lamiifolium

&lt;i&gt;In Vitro&lt;/i&gt; Antiprotozoal Activities and Cytotoxicity of Selected Sudanese Medicinal Plants

Antiplasmodial activity of methanol leaf extract of Citrus aurantifolia (Christm) Swingle

Contact Info

Product

Resources

About

<i>In Vitro</i> Antiprotozoal Activities and Cytotoxicity of Selected Sudanese Medicinal Plants