Antimalarial Activity of Sesquiterpene Lactones from Vernonia cinerea.

Chea, Aun; Hout, Sotheara; Long, Christophe; Marcourt, Laurence; Faure, Robert; Azas, Nadine; Élias, Riad

doi:10.1002/chin.200714191

Cited by 20 publications

(21 citation statements)

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“…One study shows that the administration of V. cinerea can inhibit the elevated proinflammatory cytokine level in the carrageenan-induced paw edema model (Kumar and Kuttan, 2009). Vernolides are major sesquiterpenoids reported in this plant and are considered as the active principle (Kuo et al, 2003;Chea et al, 2006). In the present study, we, for the first time, report the effect of vernolide-A on inducing apoptosis in B16F-10, a highly metastatic melanoma cell.…”

Section: Research Articlementioning

confidence: 83%

Vernolide-A, a sesquiterpene lactone fromVernonia cinerea,induces apoptosis in B16F-10 melanoma cells by modulating p53 and caspase-3 gene expressions and regulating NF-κB-mediated bcl-2 activation

Pratheeshkumar

Kuttan

2011

Drug and Chemical Toxicology

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In this study, we investigated the effect of vernolide-A on the induction of apoptosis as well as its regulatory effect on the activation of transcription factors in B16F-10 melanoma cells. Treatment of B16F-10 cells with nontoxic concentrations of vernolide-A showed the presence of apoptotic bodies and induced DNA fragmentation in a dose-dependent manner. Cell-cycle analysis and TUNEL assays also confirmed the observation. The proapoptotic genes, p53, Bax, caspase-9, and caspase-3, were upregulated in vernolide-A-treated cells, whereas the antiapoptotic gene, Bcl-2, was downregulated. vernolide-A treatment also showed a downregulation of cyclin D1 expression and upregulated p21 and p27 gene expression in B16F-10 melanoma cells. The study also reveals that vernolide-A treatment could alter the production and expression of proinflammatory cytokines and could inhibit the activation and nuclear translocation of p65, p50, and c-Rel subunits of nuclear factor-κB and other transcription factors, such as c-fos, activated transcription factor-2, and cyclic adenosine monophosphate response-element-binding protein in B16F-10 melanoma cells. These results suggest that vernolide-A induces apoptosis via activation of p53-induced, caspase-3-mediated proapoptotic signaling and suppression of NF-κB-induced, bcl-2-mediated survival signaling.

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Section: Research Articlementioning

confidence: 83%

Vernolide-A, a sesquiterpene lactone fromVernonia cinerea,induces apoptosis in B16F-10 melanoma cells by modulating p53 and caspase-3 gene expressions and regulating NF-κB-mediated bcl-2 activation

Pratheeshkumar

Kuttan

2011

Drug and Chemical Toxicology

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“…Another study showed a good antiplasmodial activity of vernolide C and D molecules against W2 . This activity could be due to the presence of alkaloids (Bruneton, 1993) and triterpenes in the plant which mentioned by Chea et al (2006). Alkaloids are one of the most important classes of natural products providing drugs since ancient times.…”

Section: Resultsmentioning

confidence: 99%

Antiplasmodial activity of Vernonia cinerea Less (Asteraceae), a plant used in traditional medicine in Burkina Faso to treat malaria

Soma¹,

Sanon²,

GansanÃ³

et al. 2017

Afr. J. Pharm. Pharmacol.

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Research and development of new antiplasmodial molecules in plant is a very important way for the development of new anti-malarial drugs. In this study, Vernonia cinerea Less (Asteraceae) was selected for its promising antiplasmodial activity because it is traditionally used in Burkina Faso to treat malaria. The aim of this study was to investigate the antiplasmodial activity of this whole plant. Five crude extracts of V. cinerea Less were prepared from the solvents of increasing polarity (CH 2 Cl 2 , CH 3 OH, CH 3 OH/H 2 O (1/1), H 2 O and alkaloids extracts). The method of Ciulei (1982) and thin layer chromatography were used for chemical characterization. The p-LDH technique was used in vitro. Extracts were evaluated in vitro for efficacy against the Plasmodium falciparum strain K1, which is resistant to chloroquine, and 3D7, which is sensitive to chloroquine. The crude extracts of alkaloids showed the IC 50 =4.25 μg/ml with the strains 3D7 and IC 50 =2.56 µg/ml with the K1 strains. The CH 2 Cl 2 extracts showed the IC 50 = 8.42 µg/ml and IC 50 =5.85 µg/ml on strains 3D7 and K1, respectively. The CH 3 OH extracts showed the IC 50 =21.08 µg/ml, CH 3 OH/H 2 O extracts gave 41.56 µg/ml and H 2 O extracts gave 37.17 µg/ml on strains of P. falciparum K1. The present study highlighted the very promising antiplasmodial activity of V. cinerea Less. The most antiplasmodial activity of this plant extracts merit further study about its in vivo antiplasmodial activity in Plasmodium berghei infected mice.

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“…Sequiterpene lactone from Vernonia cinerea (Chea et al, 2006), and the endoperoxide sesquiterpene lactone, artemisinin from A. annua (Klayman, 1985;Hien and White, 1993) are also from the same family. Artemisinin based combinations are among the best-recommended drugs for treatment of resistant Plasmodium parasites (Nosten and White, 2007).…”

Section: Discussionmentioning

confidence: 99%

Antimicrobial activity and phytochemical fingerprints of five crude extracts obtained from indigenous medicinal plants of Uganda

Katuura¹,

Bossa²,

Waako³

et al. 2017

Res. Pharm. Biotech.

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Five crude extracts from four Ugandan plants were screened in vitro for their antimicrobial activity and phytochemical composition. They included the chloroform extracts of Bothliocline longipes, Maesa lanceolata, Trimeria bakeri, Rhus natalensis and the petroleum ether extract of T. bakeri. The plant crude extracts were tested against Staphylococcus aureus (ATCC 25923), Escherichia coli (ATCC 25922), Pseudomonas aeruginosa (ATCC 49619) and Entamoeba sp. Antimicrobial activities of the plants were determined by using the agar well diffusion and agar well dilution methods. The plant extracts showed activity against all the tested organisms with the zones of inhibition ranging from 4 to 19 mm. All the extracts inhibited the growth of S. aureus while the strongest activity was found for T. bakeri against S. aureus and Entamoeba sp. at 19 mm. Other plant extracts that induced strong antimicrobial activity were the chloroform extract of R. natalensis with an inhibition diameter of 13 mm against both S. aureas and P. aeruginosa and 9 mm diameter inhibition against E. coli. Only T. bakeri showed growth inhibition of S. aureus (4 mm). The minimum inhibitory concentration (MIC) was observed against S. aureus at 0.25 g/ml by the T. bakeri and B. longipes plant extracts. Sterol and triterpenes, fatty acids, flavanoids, coumarins and alkaloids were determined in T. bakeri, B. longipes, R. natalensis and M. lanceolata. The presence of these compounds indicates that the plants may contain an active compound or one that can be used as a template for the development of a new antimalarial or antibiotic medicine.

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Antimalarial Activity of Sesquiterpene Lactones from Vernonia cinerea.

Cited by 20 publications

References 1 publication

Vernolide-A, a sesquiterpene lactone fromVernonia cinerea,induces apoptosis in B16F-10 melanoma cells by modulating p53 and caspase-3 gene expressions and regulating NF-κB-mediated bcl-2 activation

Vernolide-A, a sesquiterpene lactone fromVernonia cinerea,induces apoptosis in B16F-10 melanoma cells by modulating p53 and caspase-3 gene expressions and regulating NF-κB-mediated bcl-2 activation

Antiplasmodial activity of Vernonia cinerea Less (Asteraceae), a plant used in traditional medicine in Burkina Faso to treat malaria

Antimicrobial activity and phytochemical fingerprints of five crude extracts obtained from indigenous medicinal plants of Uganda

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