Antimalarial Artemisinin Analogs: Synthesis of 2,3-Desethano-12-deoxoartemisinin-related Compounds

Enantiomeric Isopulegol as the Chiral Pool in the Total Synthesis of Bioactive Agents

“…[211] To investigate pharmacological properties of the 1,2,4-trioxane ring system, a simple analogue of 322, desethanoartemisinin 329, containing cyclic peroxide lactone moiety present in the natural product, [211] was synthesised from (À )-2 by Imakura et al in 1988. [212,213] Hydroboration of (À )-2 followed by oxidation with Jones reagent then methylation with CH 2 N 2 gave a ketomethyl ester 326. Wittig reaction of 326 afforded the enol methyl ether 327.…”

Role of Natural Products in Drug Discovery

“…Especially modern methods such as functional genomics can help to elucidate the mode of action of these traditional medicines [53]. Several drugs including artemisinebased antimalarials [54][55][56][57] or a synthetic analog of schizandrin C for the treatment of chronic hepatitis [58] have originated from these fields of research.…”

Synthesis and Crystal Structure of Pyrazoline Derivative of Pulegone

“…[7][8][9][10][11] (R)-(+)-Pulegone (1) had been used for the synthesis of pheromones. 1-6 This monoterpene and its isomers had been utilized as chiral building blocks for the total synthesis of natural compounds.…”