Antimalarial Compounds from the Stem Bark of Vismia laurentii

Noungoue, Diderot Tchamo; Chaabi, Mehdi; Ngouela, Silvère; Antheaume, Cyril; Boyom, Fabrice Fekam; Gut, Jiří; Rosenthal, Philip J.; Lobstein, Annelise; Tsamo, Etienne

doi:10.1515/znc-2009-3-410

Cited by 21 publications

(14 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Regarding (71), because in the same study other related compounds were not tested, it is not possible to infer structure-activity links. However, from this family of compounds, it would seem safe to conclude that the quinone substitution interferes with activity and that the substitution with increasingly lipophilic chains might also improve antiplasmodial activity [96].…”

Section: Quinones Anthrones and Derivativesmentioning

confidence: 99%

Natural Phenolic Compounds and Derivatives as Potential Antimalarial Agents

et al. 2020

View full text Add to dashboard Cite

Malaria is a parasitic disease endemic to tropical and subtropical regions responsible for hundreds of millions of clinical cases and hundreds of thousands of deaths yearly. Its agent, the Plasmodium sp., has a highly variable antigenicity, which accounts for the emergence and spread of resistance to all available treatments. In light of this rising problem, scientists have turned to naturally occurring compounds obtained from plants recurrently used in traditional medicine in endemic areas. Ethnopharmacological approaches seem to be helpful in selecting the most interesting plants for the search of new antiplasmodial and antimalarial molecules. However, this search for new antimalarials is complex and time-consuming and ultimately leads to a great number of interesting compounds with a lack of discussion of their characteristics. This review aims to examine the most promising antiplasmodial phenolic compounds (phenolic acids, flavonoids, xanthones, coumarins, lignans, among others) and derivatives isolated over the course of the last 28 y (1990 – 2018) and discuss their structure-activity relationships, mechanisms of action, toxicity, new perspectives they could add to the fight against malaria, and finally, the difficulties of transforming these potential compounds into new antimalarials.

show abstract

Section: Quinones Anthrones and Derivativesmentioning

confidence: 99%

Natural Phenolic Compounds and Derivatives as Potential Antimalarial Agents

et al. 2020

View full text Add to dashboard Cite

show abstract

“…A phytochemical study of the stem bark of V. laurentii resulted in the isolation of a vismiaquinone A (7), vismiaquinone B (8), bivismiaquinone (10), betulinic acid (70), tetracyclic triterpene, tirucalla-7,24-dien-3-one (125), 3-geranyloxyemodin (126), epifriedelinol (127), and stigmasta-7,22-dien-3-ol (128) (Noungoue et al, 2009) (Figure 11). The extracts and compounds were tested for antimalarial activity and demonstrated toxicity to erythrocytes at concentrations above 2 mg/mL, i.e., many orders of magnitude above the concentrations of compounds with antimalarial activity.…”

Section: (Figure 2)mentioning

confidence: 99%

Chemistry and biology of genusVismia

Hussain

Al‐Harrasi

Saleem

et al. 2012

Pharmaceutical Biology

View full text Add to dashboard Cite

“…In the fruits and seeds of Vismia laurentii , the xanthones [13], anthraquinones [14], [15] and naphtoquinones are thought to be responsible for the anticancer [16] potential, as well as for the antimicrobial [17] and anti-malarial [18] activities of this plant extract.…”

Section: Introductionmentioning

confidence: 99%

Anticancer and Antimicrobial Activities of Some Antioxidant-Rich Cameroonian Medicinal Plants

et al. 2013

View full text Add to dashboard Cite

Traditional remedies have a long-standing history in Cameroon and continue to provide useful and applicable tools for treating ailments. Here, the anticancer, antimicrobial and antioxidant activities of ten antioxidant-rich Cameroonian medicinal plants and of some of their isolated compounds are evaluated.The plant extracts were prepared by maceration in organic solvents. Fractionation of plant extract was performed by column chromatography and the structures of isolated compounds (emodin, 3-geranyloxyemodin, 2-geranylemodin) were confirmed spectroscopically. The antioxidant activity (AOA) was determined using the 1,1-diphenyl-2-picrylhydrazyl (DPPH) bleaching method, the trolox equivalent antioxidant capacity (TEAC), and the hemoglobin ascorbate peroxidase activity inhibition (HAPX) assays. The anticancer activity was evaluated against A431 squamous epidermal carcinoma, WM35 melanoma, A2780 ovary carcinoma and cisplatin-resistant A2780cis cells, using a direct colorimetric assay. The total phenolic content in the extracts was determined spectrophotometrically by the Folin–Ciocalteu method. Rumex abyssinicus showed the best AOA among the three assays employed. The AOA of emodin was significantly higher than that of 3-geranyloxyemodin and 2-geranylemodin for both TEAC and HAPX methods. The lowest IC50 values (i.e., highest cytotoxicity) were found for the extracts of Vismia laurentii, Psorospermum febrifugum, Pentadesma butyracea and Ficus asperifolia. The Ficus asperifolia and Psorospermum febrifugum extracts are selective against A2780cis ovary cells, a cell line which is resistant to the standard anticancer drug cisplatin. Emodin is more toxic compared to the whole extract, 3-geranyloxyemodin and 2-geranylemodin. Its selectivity against the platinum-resistant A2780cis cell line is highest. All of the extracts display antimicrobial activity, in some cases comparable to that of gentamycin.

show abstract

Antimalarial Compounds from the Stem Bark of Vismia laurentii

Cited by 21 publications

References 17 publications

Natural Phenolic Compounds and Derivatives as Potential Antimalarial Agents

Natural Phenolic Compounds and Derivatives as Potential Antimalarial Agents

Chemistry and biology of genusVismia

Anticancer and Antimicrobial Activities of Some Antioxidant-Rich Cameroonian Medicinal Plants

Contact Info

Product

Resources

About