Antimalarial Drug Discovery from Natural and Synthetic Sources
Nik Nur Solehah Fitri Nik Mohd Azam,
Shatrah Othman,
Yeun-Mun Choo
Abstract:Malaria remains a significant global health threat despite extensive efforts
aimed at its eradication. Numerous challenges persist in eliminating the disease, chief
among them being the parasite's ability to mutate, resulting in drug resistance. The discovery
of antimalarial drugs has relied on both phenotypic and target-based approaches.
While phenotypic screening has identified promising candidates, target-based methods
offer a more precise approach by leveraging chemically validated targets and computationa… Show more
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