Antimalarial Drugs-Induced Hepatic Injury in Rats and the Protective Role of Carnosine

Effect of Methanol Extract of <i>Gomphrena celesioides</i> on Chloroquine-Induced Hepatotoxicity and Oxidative Stress in Male Wistar Rats

“…CAT, GPx and GST a phase II drug-metabolizing enzyme. This result is in agreement with the work of [42]. Farombi and Emerole [43] reported that chloroquine increased the cholesterol/phospholipid ratio, thereby disrupting mem- Increased ROS level affect some potential targets in cells including membrane lipids and cellular proteins [45].…”

Case Report: Hepatotoxicity Associated with the Use of Hydroxychloroquine in a Patient with COVID-19

“…10,30 The mechanisms of hepatic injury related to HCQ are poorly established, and toxicity may be due to reactive metabolites and oxidative stress induced by this drug or an idiosyncratic toxic or synergistic effect associated with inflammatory processes. 26,31,32 Referring to an experimental rat model, Nikanahad et al have suggested that concomitant inflammatory processes, including those induced by infections such as malaria, may increase liver damage caused by antimalarial drugs. 32 Therefore, the potential deleterious synergistic effect of COVID-19 infection and antimalarial drugs needs to be assessed.…”

Cytoprotective Properties of Carnosine against Isoniazid-Induced Toxicity in Primary Cultured Rat Hepatocytes

“…Moreover, CAR efficiently attenuates liver damages with different etiologies. 17,[21][22][23][24][25][26] The current study was designed to evaluate the potential protective properties of CAR against INH-induced toxicity in primary rat hepatocyte culture.…”