Antimalarial potency of the leaf extract of Aspilia africana (Pers.) C.D. Adams

Christian, Akuodor Godwin; Mfon, Amos Grace; Dick, Essien Augustine; David-Oku, Esien; Linus, Akpan Joseph; Chukwuma, Ezeokpo Basil

doi:10.1016/s1995-7645(12)60010-8

Cited by 17 publications

(12 citation statements)

References 16 publications

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“…A literature survey revealed that some plants tested in this study had also shown some antiplasmodial and/or antitrypanosomal activities in the previous reports. 5,7,10,[14][15][16]19 Our study showed that A. aspilia, S. alata, F. glumosa and B. buonopozense elicited low in-vitro antiplasmodial activity (IC50 > 20); M. morindiodes was inactive (IC50 > 50) while S. jollyannum showed moderate antiplasmodial activity (10 < IC50 < 20).…”

Section: Resultsmentioning

confidence: 99%

Evaluation of In Vitro Antiprotozoal and Cytotoxic Activities of Selected Medicinal Plants used in Nigerian Folk Medicine

2021

TJNPR

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The importance of plants as a source of new chemical entities in drug discovery can never be overemphasized. To date, plant-based natural products are still an important lead to the discovery and design of new biologically active molecules. 1 Over 51 % of new small molecule drugs (molecular weight < 500) are natural compounds; natural products derived or inspired by structures of active natural compounds and have yet to be minded from many plants, marine environments, microbial world, toxins, venoms and animals. 1 Rural dwellers still rely on folk medicines for the treatment of infectious diseases. The medicines are usually prepared as decoctions, infusions, powders, ashes, teas or as poultices. 2 The herbal preparations are administered by traditional healers whose expertise in diagnosis, preparations, treatments and follow-up is usually not documented. 3 The practitioners also claim that their procedures are cheaper, safer and more effective than orthodox medicines. The claimed affordability is usually attributed to the availability of these plants within their community. In most cases, however, the claimed safety and efficacy need to be validated. It is, therefore, necessary to scientifically validate the potential use of folk medicines for the treatment of parasitic infections, which plants present a good alterna-

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Section: Resultsmentioning

confidence: 99%

Evaluation of In Vitro Antiprotozoal and Cytotoxic Activities of Selected Medicinal Plants used in Nigerian Folk Medicine

2021

TJNPR

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“…It is proposed that the presence of alkaloids, triterpenoids, flavonoids, phenolics, and tannins could be responsible for the observed curative antiplasmodial activities of the extract but further experiments are needed to confirm this hypothesis. Some alkaloids that act against malaria parasites inhibit protein synthesis by intercalating with DNA of the parasite (Okokon et al 2008;Christian et al 2012). In addition, flavonoids and tannins have been suggested to act as primary antioxidants or free radical scavengers that can counteract the oxidative damage induced by the malaria parasite (Gautam et al 2011;Kayani et al 2016).…”

Section: Discussionmentioning

confidence: 99%

In vitro and In vivo Antiplasmodial of Stem Bark Extract of Garcinia husor

et al. 2019

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Garcinia husor is one of the folk medicines in Maluku-Indonesia. This species has been used for the treatmet of Malaria disease. The phytochemical contents and antiplasmodial activity not reported yet. In this study we evaluated the quantitative phytochemicals, in vitro and in vivo antiplasmodial activity of stem bark ethyl acetate extract. In vitro assay was done using P. falciparum 3D7 strain sensitive of chloroquine. For in vivo analysis, four groups of M. musculus were infected by P. berghei and their parasitemia levels were for 7 days of treatment with ethyl acetate extract; hematological and biochemical parameter were analyzed at the end of experiment. The result showed ethyl acetate extract with the TPC (169.47 mg GAE/100 g ±0.61) and TPC (167.37 mg QE/100 g ±1.05) was active against P. falciparum 3D7 strain (IC50 value of 0.31±0.43 μg/ml). The animal treated with extract showed suppression of parasitemia to 87.57±1.41% compared with the P. berghei infected-mice (negative control), ED50 value of 22.30 mg/kg BW. The dose of extract in 200 mg/kg BW was reduce parasitemia of infected mice with P. berghei more potential. The ethyl acetate of the stem bark G. husor with has antiplasmodial properties and future investigation are necessary to elucidate its mechanism of action.

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“…This was prepared by determining percentage parasitemia and the erythrocytes count of the donor mouse and diluting them with normal saline in proportions indicated by both determinations [10] . Each mouse was inoculated intraperitoneally with infected blood suspension (0.2 mL) containing 1伊10 7 P. berghei parasitized red blood cells.…”

Section: Inoculamentioning

confidence: 99%

“…On Day 3, thin films were made from the tail blood of each mouse. The films were fixed with methanol, stained with 10% Giemsa and parasite density determined by microscopically (Olympus CX 21, Japan) counting the parasitized red blood cells on at least 1 000 red blood cells in 10 different fields [10] .…”

Section: Suppressive Testmentioning

confidence: 99%

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Antimalarial potency of the methanol leaf extract of Maerua crassifolia Forssk (Capparaceae)

Christian

Akanimo

Ahunna

et al. 2014

Asian Pacific Journal of Tropical Disease

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Antimalarial potency of the leaf extract of Aspilia africana (Pers.) C.D. Adams

Abstract: The findings show that ethanol extract of A. africana leaf possesses potent antiplasmodial activity which justify the use in ethnomedicine and can be developed in malaria therapy.

Cited by 17 publications

References 16 publications

Evaluation of In Vitro Antiprotozoal and Cytotoxic Activities of Selected Medicinal Plants used in Nigerian Folk Medicine

Evaluation of In Vitro Antiprotozoal and Cytotoxic Activities of Selected Medicinal Plants used in Nigerian Folk Medicine

In vitro and In vivo Antiplasmodial of Stem Bark Extract of Garcinia husor

Antimalarial potency of the methanol leaf extract of Maerua crassifolia Forssk (Capparaceae)

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