Antimalarial tetranortriterpenoids from the seeds of Lansium domesticum Corr.

Saewan, Nisakorn; Sutherland, John D.; Chantrapromma, Kan

doi:10.1016/j.phytochem.2006.07.005

Cited by 71 publications

(64 citation statements)

References 19 publications

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“…Some researchers have reported the findings on antimalarial tetranortriterpenoids from langsat seeds (Nishizawa et al 1988;Saewan et al 2006) and isolation of cycloartanoid triterpene from langsat leaves (Nishizawa et al 1989). Judging from the physical form of the fruit and seeds, most common dryers are suitable to be employed to dry langsat and its seeds.…”

Section: Langsatmentioning

confidence: 99%

Drying of Exotic Tropical Fruits: A Comprehensive Review

Fernandes

Law

Mujumdar

2010

Food Bioprocess Technol

166

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This paper provides a capsule overview of recent experimental studies dealing with the drying of a large assortment of tropical and subtropical fruits, also called "exotic" fruits. The term exotic includes a number of tropical fruits that are not yet commonly found in global markets but do have the potential to do so in view of their appearance, taste, and textural and nutritional quality parameters. As the consumer is seeking diverse tastes and flavors without compromising on quality, it is logical to expect the market for dried exotic fruits to increase over the next decade. This review covers diverse drying techniques, drying kinetics, and key quality parameters of dried fruits.

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Section: Langsatmentioning

confidence: 99%

Drying of Exotic Tropical Fruits: A Comprehensive Review

Fernandes

Law

Mujumdar

2010

Food Bioprocess Technol

166

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“…Triterpenoid has also been reported as antimalarial agent. A study showed that triterpenoid that isolated from Lansium domesticum had antimalarial activity with IC 50 5.9 µg/mL (Saewan, 2006). Betulinic acid (pentacyclic triterpens) can fuse with erythrocyte membrane then enter into the cell through lipid bilayer, as a result growth and invasion of malaria parasite are inhibited (Ziegler 2004).…”

Section: Resultsmentioning

confidence: 99%

The Effectiveness of Local Plants from Lom and Sawang Ethnics as Antimalarial Medicine

2016

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Native people or ethnic societies that live in endemic malaria islands such as in Bangka Island and Belitung Island have used many medicinal plants to cure malaria. Leaves of kesembung (Scaevola taccada (Gaertn Roxb), roots of kebentak (Wikstroemia androsaemofolia Decne), and roots of medang mencena (Dapniphyllum laurinum (Benth) are the examples. This research was aimed to investigate the present of some biochemical compound and evaluate the antimalarial activity of ethanol extract of the plants against Plasmodium falciparum 3D7 in vitro. The IC50 level was determined through visual observation under microscope over 5000 of giemsastained erythrocytes then analyzed by probit analysis. Results showed that kebentak root ethanol extract was effective to inhibit P. falciparum 3D7 with level 0.485 µg/ mL. Furthermore, the IC50 level of kesembung leaves and medang root were 44.352 µg/mL and 1486.678 µg/mL respectively. Phytochemical test result showed that kebentak leaf ethanol crude extract contained triterpenoid, kesembung root contained phenol and tannins; moreover, medang root contained alkaloid, saponin, and triterpenoid.

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“…Beberapa penelitian menunjukkan duku memiliki efek antimikroba (Marfori, Kajiyama, Fukusaki & Kobayashi, 2015;Manik, Khotimah & Fitrianingrum 2014). Penelitian lain juga menyatakan esktrak biji buah duku memiliki efek antimalaria (Yapp & Yap, 2003;Saewan, Sutherland & Chantrapromma, 2006), efek larvasida terhadap nyamuk Aedes aegypti (Ni'mah, Oktarina, Mahdalena & Asyati, 2015) dan dapat digunakan sebagai anti nyamuk elektrik (Mirnawaty, Supriadi & Jaya, 2012). Selain itu, penelitian di Thailand menyebutkan esktrak tanaman duku mempunyai efek antikanker, antiproliferasi sel, dan antioksidan dan mampu mencegah kerusakan DNA akibat radikal bebas (Penpu, 2012;Manosroi, Jantrawut, Sainakham, Manosroi, & Manosroi, 2012;Manosroi, Chankhampan, Manosroi, & Manosroi, 2013;Klungsupya et al, 2012;Klungsupya, Suthepakul, Muangman, Rerk-Am, & Thongdon, 2015).…”

Section: Pendahuluanunclassified

Antioxidant Potential Of Lansium Domesticum Corr. Seed Extract In White Male Rat (Rattus Novergicus) Induced By Alcohol

Subandrate

Sinulingga

Wahyuni

et al. 2016

Molekul

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Potensi Antioksidan Ekstrak Biji Duku (Lansium Domesticum Corr. Analisis uji ANOVA menunjukkan ada satu kelompok yang memiliki perbedaan rata-rata baik kadar GSH (p=0,00) maupun kadar MDA (p=0,00). Analisis uji post hoc terhadap kadar GSH dan MDA menunjukkan hanya kelompok dosis 100 mg/kgbb yang memiliki perbedaan yang bermakna (p=0,00). Dengan demikian, ekstrak biji duku (Lansium domesticum Corr.) memiliki potensi antioksidan dan optimum pada dosis 100 mg/kgbb.Kata Kunci: antioksidan, ekstrak biji duku, GSH, MDA ABSTRACTLansium domesticum Corr. is a typical plant of Indonesia. The seeds have a lot of useful compounds, such as flavonoids. Flavonoids are a natural compound that can act as antioxidants. The aim of this study was to determine the antioxidant potential of Lansium domesticum Corr. seed extract. This study was an experimental research with posttest control group design. The subjects were 32 white male rats. Rats were randomly divided into 4 groups: negative control group was given suspension of Na CMC 1%, dose group I, II and III were given Lansium domesticum Corr. seed extract with each dose of 100mg/kg, 200 mg/kg, and 300 mg/kg. Observation of the subject's response was done by measuring the levels of glutathione (GSH) and malondialdehyde (MDA). Analysis ANOVA test showed that there was a group that had an average difference both GSH levels (p=0.00) and MDA levels (p=0.00). Post hoc test analysis for GSH levels and MDA levels showed that only a dose of 100 mg/kg which have significant differences (p=0.00). Thus, Lansium domesticum Corr. seed extract has antioxidant potential and optimum dose of 100 mg/kg.

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Antimalarial tetranortriterpenoids from the seeds of Lansium domesticum Corr.

Cited by 71 publications

References 19 publications

Drying of Exotic Tropical Fruits: A Comprehensive Review

Drying of Exotic Tropical Fruits: A Comprehensive Review

The Effectiveness of Local Plants from Lom and Sawang Ethnics as Antimalarial Medicine

Antioxidant Potential Of Lansium Domesticum Corr. Seed Extract In White Male Rat (Rattus Novergicus) Induced By Alcohol

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