Antimalarial xanthones from Calophyllum caledonicum and Garcinia vieillardii

Hay, Anne‐Emmanuelle; Hélesbeux, Jean-Jacques; Duval, Olivier; Labaïed, Medhi; Grellier, Philippe; Richomme, Pascal

doi:10.1016/j.lfs.2004.07.009

Cited by 112 publications

(91 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…2 They are also have various biological properties, such as antiviral 3 and antimalarial properties, 4 induction of HL-60 cellular differentiation, 5 and inhibition of Epstein-Barr virus activities. 6 Among these alkaloids, acronycine (1) is isolated from the bark of Acronychia baueri 7 and exhibits strong antitumor and antiproliferative activities on several tumor models, including leukemia, sarcoma, myeloma, carcinoma, and melanoma.…”

Section: Methodsmentioning

confidence: 99%

New Synthetic Routes to Acronycine, Noracronycine, and Their Analogues

Hari¹,

Lee²,

Wang³

et al. 2010

Bulletin of the Korean Chemical Society

View full text Add to dashboard Cite

Section: Methodsmentioning

confidence: 99%

New Synthetic Routes to Acronycine, Noracronycine, and Their Analogues

Hari¹,

Lee²,

Wang³

et al. 2010

Bulletin of the Korean Chemical Society

View full text Add to dashboard Cite

“…Comanche Indians in North America used the Osage orange roots decoction to treat sore eyes [4]. M. pomifera and its components possess several biological activities including cytotoxic, antitumor, antibacterial, estrogenic, antifungal, antiviral, and antimalarial activities [5][6][7][8][9][10][11][12][13]. Recently, isoflavones isolated from Osage orange have been demonstrated to protect brain cells, or neurons, from the toxic effect of amyloid beta peptide, which is believed to be responsible for the degeneration of neurons in Alzheimer's disease patients.…”

Section: Introductionmentioning

confidence: 99%

Isolation and biological evaluation of prenylated flavonoids from Maclura pomifera

Ross

Orazbekov

Radhakrishnan

et al. 2017

Planta Medica International Open

View full text Add to dashboard Cite

Phytochemical analysis of the ethanolic extract of Maclura pomifera fruits yielded four new compounds (I-IV) along with eleven known compounds (V-XV). The crude extract exhibited significant activity towards cannabinoid receptors (CB1: 103.4% displacement; CB2: 68.8% displacement) and possibly allosteric interaction with and opioid receptors (−49.7 and −53.8% displacement, resp.). Compound I was found to be possibly allosteric for and opioid receptors (−88.4 and −27.2% displacement, resp.) and showed moderate activity (60.5% displacement) towards CB1 receptor. Compound II exhibited moderate activity towards cannabinoid receptors CB1 and CB2 (47.9 and 42.3% displacement, resp.). The known compounds (V-VIII) exhibited prominent activity towards cannabinoid receptors: pomiferin (V) (IC 50 of 2.110 and 1.318 M for CB1 and CB2, resp.), auriculasin (VI) (IC 50 of 8.923 M for CB1), warangalone (VII) (IC 50 of 1.670 and 4.438 M for CB1 and CB2, resp.), and osajin (VIII) (IC 50 of 3.859 and 7.646 M for CB1 and CB2, resp.). The isolated compounds were also tested for inhibition of human monoamine oxidase-A and monoamine oxidase-B enzymes activities, where all the tested compounds showed fewer inhibitory effects on MAO-A compared to MAO-B activities: auriculasin (VI) (IC 50 of 1.91 and 45.98 M for MAO-B and MAO-A, resp.).

show abstract

“…This genus has been shown to possess a number of secondary metabolites such as xanthones [1][2][3], coumarins [4,5], and chromanone acids [6,7]. Many of these compounds have shown a wide range of biological and pharmacological properties such as anti-HIV [8,9], anticancer [10,11], and antimalarial properties [12].…”

Section: Introductionmentioning

confidence: 99%

5,9,11-Trihydroxy-10-(2″-hydroxy-3″-methylbut-3″-en-1-yl)-2,2-dimethyl-3-(2′-methylbut-3′-en-2′-yl)-2H,12H-pyrano[2,3-a]xanthen-12-one from Calophyllum pseudomole

Tanjung¹,

Saputri²,

Tjahjandarie³

2017

Molbank

View full text Add to dashboard Cite

Abstract:A new pyranocoumarin, namely 5,9,11-trihydroxy-10-(2 -hydroxy-3 -methylbut-3 en-1-yl)-2,2-dimethyl-3-(2 -methylbut-3 -en-2 -yl)-2H,12H-pyrano[2,3-a]xanthen-12-one 1, was isolated from the stem barkof Calophyllum pesudomole. The structure of compound 1 was elucidated based on its ultaraviolet (UV); infrared (IR); high resolution electro spray ionization mass spectrometry (HRESIMS); 1D and 2D nuclear magnetic resonance (NMR) spectral data.

show abstract

Antimalarial xanthones from Calophyllum caledonicum and Garcinia vieillardii

Cited by 112 publications

References 26 publications

New Synthetic Routes to Acronycine, Noracronycine, and Their Analogues

New Synthetic Routes to Acronycine, Noracronycine, and Their Analogues

Isolation and biological evaluation of prenylated flavonoids from Maclura pomifera

5,9,11-Trihydroxy-10-(2″-hydroxy-3″-methylbut-3″-en-1-yl)-2,2-dimethyl-3-(2′-methylbut-3′-en-2′-yl)-2H,12H-pyrano[2,3-a]xanthen-12-one from Calophyllum pseudomole

Contact Info

Product

Resources

About