Antimalarials – are they effective and safe in rheumatic disease? Focus on the neuropsychiatric side effects

Manzo, Ciro

doi:10.5114/reum.2018.79506

Cited by 3 publications

(2 citation statements)

References 7 publications

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“…It is an important drug for the treatment of malaria and rheumatic diseases. [2][3][4][5] There is also some literature suggesting that HCQ can be used for tumor therapy. [6] The salt form of an Active Pharmaceutical Ingredient (API) has a long and successful track record in modifying its physicochemical and biopharmaceutical properties.…”

Section: Introductionmentioning

confidence: 99%

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Exploring New Solid Forms of Antirheumatic Drug Hydroxychloroquine: Novel Salts with Sustained‐Release Performance

Ji,

Wu,

Hong

et al. 2024

Cryst. Res. Technol.

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Hydroxychloroquine sulfate is a common drug for the treatment of rheumatoid arthritis. However, the disadvantage of this drug is that it needs to be taken continuously for 3–6 months to be effective and compliance of patients is poor. In this work, four new salt forms of hydroxychloroquine are successfully prepared whose crystal structures and properties are confirmed by a series of solid‐state characterization methods, including infrared spectroscopy, single crystal X‐ray diffraction, powder X‐ray diffraction, thermal analysis, and dynamic vapor sorption analysis. The hygroscopicity, stability, equilibrium solubility, and intrinsic dissolution rate of the four new salts are also tested. The moisture absorption, solubility, and intrinsic dissolution rate of newly prepared salts are significantly reduced, and the dissolution rates of 1‐hydroxy‐2‐naphthoate and 1,5‐naphthalenedisulfonate salts are only 1/158 and 1/335 of that of the therapeutically used sulfates, respectively. It is expected that they are potentially useful to be developed into a sustained‐release formulation, which can greatly improve the dosing compliance for rheumatoid arthritis treatment.

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Section: Introductionmentioning

confidence: 99%

“…It is an important drug for the treatment of malaria and rheumatic diseases. [ 2–5 ] There is also some literature suggesting that HCQ can be used for tumor therapy. [ 6 ]…”

Section: Introductionmentioning

confidence: 99%

Exploring New Solid Forms of Antirheumatic Drug Hydroxychloroquine: Novel Salts with Sustained‐Release Performance

Ji,

Wu,

Hong

et al. 2024

Cryst. Res. Technol.

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SARS-CoV-2 pharmaceutical drugs: a critical review on the environmental impacts, chemical characteristics, and behavior of advanced oxidation processes in water

Castañeda-Juárez

Linares-Hernández

Martínez-Miranda

et al. 2022

Environ Sci Pollut Res

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This review summarizes research data on the pharmaceutical drugs used to treat the novel SARS-CoV-2 virus, their characteristics, environmental impacts, and the advanced oxidation processes (AOP) applied to remove them. A literature survey was conducted using the electronic databases Science Direct, Scopus, Taylor & Francis, Google Scholar, PubMed, and Springer. This complete research includes and discusses relevant studies that involve the introduction, pharmaceutical drugs used in the SARS-CoV-2 pandemic: chemical characteristics and environmental impact, advanced oxidation process (AOP), future trends and discussion, and conclusions. The results show a full approach in the versatility of AOPs as a promising solution to minimize the environmental impact associated with these compounds by the fact that they offer different ways for hydroxyl radical production. Moreover, this article focuses on introducing the fundamentals of each AOP, the main parameters involved, and the concomitance with other sources and modifications over the years. Photocatalysis, sonochemical technologies, electro-oxidation, photolysis, Fenton reaction, ozone, and sulfate radical AOP have been used to mineralize SARS-CoV-2 pharmaceutical compounds, and the efficiencies are greater than 65%. According to the results, photocatalysis is the main technology currently applied to remove these pharmaceuticals. This process has garnered attention because solar energy can be directly utilized; however, low photocatalytic efficiencies and high costs in large-scale practical applications limit its use. Furthermore, pharmaceuticals in the environment are diverse and complex. Finally, the review also provides ideas for further research needs and major concerns. Graphical abstract

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Hydroxychloroquine: Key therapeutic advances and emerging nanotechnological landscape for cancer mitigation

Low,

Kong,

Yap

et al. 2023

Chemico-Biological Interactions

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Antimalarials – are they effective and safe in rheumatic disease? Focus on the neuropsychiatric side effects

Cited by 3 publications

References 7 publications

Exploring New Solid Forms of Antirheumatic Drug Hydroxychloroquine: Novel Salts with Sustained‐Release Performance

Exploring New Solid Forms of Antirheumatic Drug Hydroxychloroquine: Novel Salts with Sustained‐Release Performance

SARS-CoV-2 pharmaceutical drugs: a critical review on the environmental impacts, chemical characteristics, and behavior of advanced oxidation processes in water

Hydroxychloroquine: Key therapeutic advances and emerging nanotechnological landscape for cancer mitigation

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