Antimelanogenic Activity of Ocotillol‐Type Saponins from <i>Panax vietnamensis</i>

Nguyen, Hien Minh; Nguyen, Huy Truong; Win, Nwet Nwet; Wong, Chin Piow; Huynh, Kim Long Vu; Hoang, Nhat Nam; Minh, Kiep; Nguyen, Hoai Thi; Ho, Duc Viet; Nguyen, Mai; Morita, Hiroyuki

doi:10.1002/cbdv.202000037

Cited by 12 publications

(8 citation statements)

References 23 publications

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“…The sensing performance was excellent compared to other reported NO sensors in recent literature as illustrated in Figure S14 (Supporting Information), and the detailed sensing properties are summarized in Table S2 (Supporting Information). [51][52][53][54][55][56][57][58][59][60][61][62][63][64][65][66][67][68][69][70] As shown in Figure S15 (Supporting Information), the device's transfer and output characteristics at different NO concentrations ranging from 0 to 50 ppm were recorded to highlight the relationship between the gas interaction and transistor parameters. According to the transfer characteristics shown in Figure S15a (Supporting Information), a significant positive threshold shift from −10 to +15 V was observed, and the drain current increased from 5 to 15 µA when the NO gas concentration increased.…”

Section: Resultsmentioning

confidence: 99%

Facile Synthesis of Conductive Metal−Organic Frameworks Nanotubes for Ultrahigh‐Performance Flexible NO Sensors

Wang

Chen

et al. 2022

Small Methods

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Additionally, the number of Cu 2c (the Cu 2c in the crystal defects bound with two S atoms) in the Cu-BHT structure is the primary factor affecting the Cu-BHT-based sensing devices' performance. [6,17] However, the Cu-BHT's crystal structure makes its specific surface smaller than that of the conventional metal-organic frameworks, which significantly affects its application in electrocatalysts and sensors. Thus, the preparation of Cu-BHT with a large surface area and abundant Cu 2c on the surface is a crucial factor in improving the performance of Cu-BHT-based devices.Gaseous pollutants, emitted by car engines or other combustion processes, are attracting attention because of their threat to the human body, such as physiological dysfunctions, chronic bronchitis, and lung cancer. [18][19][20][21][22][23][24][25][26][27][28] Consequently, various materials have been utilized to detect toxic gases, such as metal oxide semiconductors, [29,30] MXene/noble metal, [31][32][33][34] ion-conducting hydrogels, and organohydrogels. [35,36] Among gaseous pollutants, nitric oxide (NO), as a marker for airway inflammations, plays a major role in biological functions and pathological processes. [37,38] Measurement of exhaled NO has applications in diagnosing and monitoring inflammation, and the information obtained can be used as a tool for managing asthma treatment. Therefore, developing sensors to detect NO gas is critical for diagnosing and monitoring an asthma patient or ambient monitoring.Among different types of NO gas sensors, organic field-effect transistor (OFET) based sensors are increasingly attracting attention owing to their gate-induced tunable channel conductivities, amplification effects, concurrent actualization of processing, memory functions, miniaturized size, solution processing, and low power consumption. [39,40] Alternatively, many parameters, such as transport mobility (μ), threshold voltage (V Th ), current on/off ratio (I on /I off ), and subthreshold swing (SS), can be characterized the gas-sensing performance in a sensor based on an OFET device. In addition, the electronic properties of the semiconductor materials can be flexibly tuned to improve specificity. [41] However, due to the weak affinity with NO gas, the OFET device's sensitivity to detect NO gas was limited. Recently, the formation of heterostructure is known to be a promising strategy to enhance sensitivity and improve selectivity of gas sensing. [42][43][44] Cu-benzenehexathiol (Cu-BHT) has attracted significant attention due to its record high electrical conductivity and crystal defects Cu 2c . However, the nonporous structure and small specific surface area of Cu-BHT with twodimensional kagome lattice invariably limit its practical application in sensing and catalysis. In this work, Cu-BHT nanotubes (Cu-BHT-NTs) are designed and prepared via a facile homogeneous reaction to solve these problems. Compared with the traditional nanorod-like structure, the Cu-BHT-NTs not only have a higher specific surface area but also possess a higher pro...

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Section: Resultsmentioning

confidence: 99%

Facile Synthesis of Conductive Metal−Organic Frameworks Nanotubes for Ultrahigh‐Performance Flexible NO Sensors

Wang

Chen

et al. 2022

Small Methods

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“…For example, quercetin 3-O-glucuronide and myricetin-3-O-galactoside have both been reported to have melanogenesis inhibitory activity [ 37 ]. Ocotillol-type saponins (tetracyclic triterpenoids), from Panax vietnamensis , have antimelanogenic activity [ 38 ]. Triterpenoid saponins from Polaskia chichipe also have either inhibitory or promotional effects on the melanogenesis of B16 melanoma cells [ 39 ].…”

Section: Discussionmentioning

confidence: 99%

Molecular Analysis of the Melanogenesis Inhibitory Effect of Saponins-Rich Fraction of Argania spinosa Leaves Extract

et al. 2022

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Plant saponins are abundant and diverse natural products with a great potential for use in drug-discovery research. Here, we evaluated extracts of saponins-rich fractions of argan leaves and argan oil extraction byproducts (shell, pulp, press cake) for their effect on melanogenesis. Results show that from among the samples tested, only the saponins-rich fraction from leaves (ALS) inhibited melanin production in B16 murine melanoma (B16) cells. The mechanism of the melanogenesis inhibition was elucidated by determining the protein and mRNA expression of melanogenesis-associated enzymes tyrosinase (TYR), tyrosinase-related protein 1 (TRP1), and dopachrome tautomerase (DCT), and microphthalmia-associated transcription factor (MITF), and performing DNA microarray analysis. Results showed that 10 µg/mL ALS significantly inhibited melanogenesis in B16 cells and human epidermal melanocytes by 59% and 48%, respectively, without cytotoxicity. The effect of ALS on melanogenesis can be attributed to the decrease in TYR, TRP1, and MITF expression at the protein and mRNA levels. MITF inhibition naturally led to the downregulation of the expression of Tyr and Trp1 genes. Results of the DNA microarray analysis revealed the effect on melanogenesis-associated cAMP and Wnt signaling pathways’ genes. The results of this study suggest that ALS may be used in cosmeceuticals preparations for hyperpigmentation treatment.

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“…The plant is endemic to Vietnam and southern China and is the southernmost species of the genus ( Ha and Grushvitzky, 1985 ; Pham et al., 2019 ; Liu et al., 2020 ; Vu et al., 2020 ). Vietnamese ginseng is a rich source of a specific group of triterpene glycosides called ginsenosides, which are common for Panax spp ( Nguyen et al., 2020 ). A wide spectrum of triterpene glycosides reported for P. vietnamensis includes ginsenosides Rb1, Rb2, Rb3, Rc, Rd, Re, Rg1, Rh1, Rh4, Rh5, and XVII; majonosides R1, R2, and F1; notoginsenosides Fa, R1, R2, and R6; vinaginsenosides R1–R25; ginsenoside R0; hemsloside Ma3; pseudoginsenosides RS1, RT4, RC1, and F11; 20-gluco-ginsenoside-Rf; 20(R)-ginsenoside-Rh1; hypenosides XVII and IX; quinquenoside R1; and protopanaxatriol oxide sapogenin II ( Duong et al., 2013 ; Xia et al., 2022 ).…”

Section: Introductionmentioning

confidence: 99%

Suspension cell cultures of Panax vietnamensis as a biotechnological source of ginsenosides: growth, cytology, and ginsenoside profile assessment

Titova,

Lunkova,

Tyurina

et al. 2024

Front. Plant Sci.

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IntroductionPanax vietnamensis is a valuable medicinal plant and a source of a broad spectrum of biologically active ginsenosides of different structural groups. Overexploitation and low adaptability to planation cultivation have made this species vulnerable to human pressure and prompted the development of cell cultivation in vitro as a sustainable alternative to harvesting wild plants for their bioactive components. Despite high interest in biotechnological production, little is known about the main factors affecting cell growth and ginsenoside biosynthesis of this species under in vitro conditions. In this study, the potential of cell cultures of P. vietnamensis as a biotechnological source of ginsenosides was was assessed.MethodsSix suspension cell lines that were developed from different sections of a single rhizome through a multi-step culture optimization process and maintained for over 3 years on media with different mineral salt base and varying contents of auxins and cytokinins. These cell lines were evaluated for productivity parameters and cytological characteristics. Ginsenoside profiles were assessed using a combination of the reversed-phase ultra-high-performance liquid chromatography–Orbitrap–tandem mass spectrometry (UHPLC–Orbitrap–MS/MS) and ultra-performance liquid chromatography–time of flight–mass spectrometry (UPLC–TOF–MS).ResultsAll lines demonstrated good growth with a specific growth rate of 0.1–0.2 day−1, economic coefficient of 0.31–0.70, productivity on dry weight (DW) of 0.30–0.83 gDW (L·day)−1, and maximum biomass accumulation varying from 10 to 22 gDW L−1. Ginsenosides of the protopanaxadiol (Rb1, Rb2/Rb3, malonyl-Rb1, and malonyl-Rb2/Rb3), oleanolic acid (R0 and chikusetsusaponin IV), and ocotillol (vinaginsenoside R1) groups and their isomers were identified in cell biomass extracts. Chikusetsusaponin IV was identified in P. vietnamensis cell culture for the first time.DiscussionThese results suggest that suspension cell cultures of Vietnamese ginseng have a high potential for the biotechnological production of biomass containing ginsenosides, particularly of the oleanolic acid and ocotillol groups.

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Antimelanogenic Activity of Ocotillol‐Type Saponins from Panax vietnamensis

Cited by 12 publications

References 23 publications

Facile Synthesis of Conductive Metal−Organic Frameworks Nanotubes for Ultrahigh‐Performance Flexible NO Sensors

Facile Synthesis of Conductive Metal−Organic Frameworks Nanotubes for Ultrahigh‐Performance Flexible NO Sensors

Molecular Analysis of the Melanogenesis Inhibitory Effect of Saponins-Rich Fraction of Argania spinosa Leaves Extract

Suspension cell cultures of Panax vietnamensis as a biotechnological source of ginsenosides: growth, cytology, and ginsenoside profile assessment

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