Antimelanoma and Antityrosinase from <i>Alpinia galangal</i> Constituents

Lo, Chih-Yu; Liu, Po-Len; Lin, Li‐Ching; Chen, Yen‐Ting; Hseu, You‐Cheng; Wen, Zhi‐Hong; Wang, Hui‐Min David

doi:10.1155/2013/186505

Cited by 31 publications

(28 citation statements)

References 18 publications

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“…However, only a few natural and synthetic depigments are used as therapeutic agents because of safety concerns and low whitening bioactivity. 4,5 Melanin synthesis in melanocytes, in which tyrosinase plays a critical role, is mediated by several enzymes. 6 The pathway of melanin biosynthesis can be divided into two main parts: the production of eumelanin (eumelanogenesis) and the production of pheomelanin (pheomelanogenesis) ( Figure 1).…”

Section: ■ Introductionmentioning

confidence: 99%

Discovery of Potent Cysteine-Containing Dipeptide Inhibitors against Tyrosinase: A Comprehensive Investigation of 20 × 20 Dipeptides in Inhibiting Dopachrome Formation

Tseng

Tsai

Chen

et al. 2015

J. Agric. Food Chem.

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Tyrosinase is an essential copper-containing enzyme required for melanin synthesis. The overproduction and abnormal accumulation of melanin cause hyperpigmentation and neurodegenerative diseases. Thus, tyrosinase is promising for use in medicine and cosmetics. Our previous study identified a natural product, A5, resembling the structure of the dipeptide WY and apparently inhibiting tyrosinase. Here, we comprehensively estimated the inhibitory capability of 20 × 20 dipeptides against mushroom tyrosinase. We found that cysteine-containing dipeptides, directly blocking the active site of tyrosinase, are highly potent in inhibition; in particular, N-terminal cysteine-containing dipeptides markedly outperform the C-terminal-containing ones. The cysteine-containing dipeptides, CE, CS, CY, and CW, show comparative bioactivities, and tyrosine-containing dipeptides are substrate-like inhibitors. The dipeptide PD attenuates 16.5% melanin content without any significant cytotoxicity. This study reveals the functional role of cysteine residue positional preference and the selectivity of specific amino acids in cysteine-containing dipeptides against tyrosinase, aiding in developing skin-whitening products.

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Section: ■ Introductionmentioning

confidence: 99%

Discovery of Potent Cysteine-Containing Dipeptide Inhibitors against Tyrosinase: A Comprehensive Investigation of 20 × 20 Dipeptides in Inhibiting Dopachrome Formation

Tseng

Tsai

Chen

et al. 2015

J. Agric. Food Chem.

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“…[19][20][21] In our presented study, the concentrations of curcumin lower than 2 μM might be no cytotoxic effect on Detroit 551 cells (Fig. 1(B)).…”

Section: Targetmentioning

confidence: 46%

Curcumin enhances the production of major structural components of elastic fibers, elastin, and fibrillin-1, in normal human fibroblast cells

Lee

Chiang

Wang

et al. 2015

Bioscience, Biotechnology, and Biochemistry

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Curcumin is the major component of the yellow extract derived from the rhizome of the Curcuma longa, which is also a main bioactive polyphenol and has been generally used as a spice, food additive, and herbal medicine. In this presented study, we found that curcumin can enhance the production of major structural components of elastic fibers, elastin, and fibrillin-1, in normal human fibroblast cells via increasing ELN and FBN1 promoters’ activities. With 2 μM curcumin treatment, the enhanced tropoelastin and fibrillin-1 protein amounts in Detroit 551 cells were approximately 134 and 130% of control, respectively. Therefore, our results demonstrated that curcumin may be used as a functional compound and applied to drugs, foods, and cosmetics in the future.

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“…In a study, Lo et al . reported that two compounds namely, 1,7‐bis(4‐hydroxyphenyl)−1,4,6‐heptatrien‐3‐one (BHPHTO) and bisdemethoxycurcumin (BDMC) can inhibit the proliferation of melanoma cells . Moreover, Faião‐Flores et al .…”

Section: Curcumin Analogs As Powerful Tools In Melanoma Therapymentioning

confidence: 99%

“…In a study, Lo et al reported that two compounds namely, 1,7-bis(4-hydroxyphenyl)21,4,6-heptatrien-3-one (BHPHTO) and bisdemethoxycurcumin (BDMC) can inhibit the proliferation of melanoma cells. 112 Moreover, Faião-Flores et al revealed that curcumin analogue DM-1, alone or in combination with dacarbazine (DTIC), shows anti-tumor effects as it inhibited melanoma progression in a melanoma mouse model. 113 In addition, no toxicological changes were observed in organs such as the spleen, kidneys, liver and lungs after the administration of DM-1, either alone or in combination with DTIC.…”

Section: Curcumin Analogs As Powerful Tools In Melanoma Therapymentioning

confidence: 99%

Curcumin: A new candidate for melanoma therapy?

Mirzaei

Naseri

Rezaee

et al. 2016

Intl Journal of Cancer

229

195

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Melanoma remains among the most lethal cancers and, in spite of great attempts that have been made to increase the life span of patients with metastatic disease, durable and complete remissions are rare. Plants and plant extracts have long been used to treat a variety of human conditions; however, in many cases, effective doses of herbal remedies are associated with serious adverse effects. Curcumin is a natural polyphenol that shows a variety of pharmacological activities including anti-cancer effects, and only minimal adverse effects have been reported for this phytochemical. The anti-cancer effects of curcumin are the result of its anti-angiogenic, pro-apoptotic and immunomodulatory properties. At the molecular and cellular level, curcumin can blunt epithelial-to-mesenchymal transition and affect many targets that are involved in melanoma initiation and progression (e.g., BCl2, MAPKS, p21 and some microRNAs). However, curcumin has a low oral bioavailability that may limit its maximal benefits. The emergence of tailored formulations of curcumin and new delivery systems such as nanoparticles, liposomes, micelles and phospholipid complexes has led to the enhancement of curcumin bioavailability. Although in vitro and in vivo studies have demonstrated that curcumin and its analogues can be used as novel therapeutic agents in melanoma, curcumin has not yet been tested against melanoma in clinical practice. In this review, we summarized reported anti-melanoma effects of curcumin as well as studies on new curcumin formulations and delivery systems that show increased bioavailability. Such tailored delivery systems could pave the way for enhancement of the anti-melanoma effects of curcumin.

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Antimelanoma and Antityrosinase from Alpinia galangal Constituents

Cited by 31 publications

References 18 publications

Discovery of Potent Cysteine-Containing Dipeptide Inhibitors against Tyrosinase: A Comprehensive Investigation of 20 × 20 Dipeptides in Inhibiting Dopachrome Formation

Discovery of Potent Cysteine-Containing Dipeptide Inhibitors against Tyrosinase: A Comprehensive Investigation of 20 × 20 Dipeptides in Inhibiting Dopachrome Formation

Curcumin enhances the production of major structural components of elastic fibers, elastin, and fibrillin-1, in normal human fibroblast cells

Curcumin: A new candidate for melanoma therapy?

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