Antimetastatic Effects of Curcumin in Oral and Gastrointestinal Cancers

Davoodvandi, Amirhossein; Farshadi, Marjan; Zare, Noushid; Akhlagh, Seyed Amirreza; Nosrani, Esmail Alipour; Mahjoubin‐Tehran, Maryam; Kangari, Parisa; Sharafi, Seyedeh Maryam; Khan, Haroon; Aschner, Michael; Baniebrahimi, Ghazaleh; Mirzaei, Hamed

doi:10.3389/fphar.2021.668567

Cited by 27 publications

(16 citation statements)

References 211 publications

(219 reference statements)

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“…Curcumin and its analogs have been shown their anticancer effects in vitro and in vivo, 67 including suppression of oral squamous cell carcinoma. 68 Through targeting EGFR mediated AKT, ERK1/2 and STAT3 pathways, curcumin inhibits SCC-25 cell growth at the dosage range of 10-80 µM. 69 Moreover, curcumin promoted apoptosis by inducing cleaved caspase 3 and cleaved PARP in YD10B OSCC cells at the dose of 10 µM.…”

Section: Discussionmentioning

confidence: 99%

Curcumin analog HO‐3867 triggers apoptotic pathways through activating JNK1/2 signalling in human oral squamous cell carcinoma cells

Chen

Hsieh

et al. 2022

J Cellular Molecular Medi

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Human oral squamous cell carcinoma (OSCC) is the common head and neck malignancy in the world. While surgery, radiotherapy and chemotherapy are emerging as the standard treatment for OSCC patients, the outcome is limited to the recurrence and side effects. Therefore, patients with OSCC require alternative strategies for treatment. In this study, we aimed to explore the therapeutic effect and the mode of action of the novel curcumin analog, HO-3867, against human OSCC cells. We analysed the cytotoxicity of HO-3867 using MTT assay. In vitro mechanic studies were performed to determine whether MAPK pathway is involved in HO-3867 induced cell apoptosis. As the results, we found HO-3867 suppressed OSCC cells growth effectively. The flow cytometry data indicate that HO-3867 induce the sub-G1 phase.Moreover, we found that HO-3867 induced cell apoptosis by triggering formation of activated caspase 3, caspase 8, caspase 9 and PARP. After dissecting MAPK pathway, we found HO-3867 induced cell apoptosis via the c-Jun N-terminal kinase (JNK)1/2 pathway. Our results suggest that HO-3867 is an effective anticancer agent as its induction of cell apoptosis through JNK1/2 pathway in human oral cancer cells.

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Section: Discussionmentioning

confidence: 99%

Curcumin analog HO‐3867 triggers apoptotic pathways through activating JNK1/2 signalling in human oral squamous cell carcinoma cells

Chen

Hsieh

et al. 2022

J Cellular Molecular Medi

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“…Previous studies has proved its efficacy on various diseases such as type 2 diabetes mellitus [ 25 ], nonalcoholic fatty liver disease [ 26 ], and head and neck squamous cell carcinoma [ 27 ]. Although evidence indicated that Curcumin inhibited migration and metastasis of oral cancer cells [ 28 ], and turmeric oil and turmeric oleoresin exhibited antitumor activity in OSMF [ 29 ], few investigations have been done on the potential targets and pathways to clarify therapeutic value of curcuma against OSMF. Network pharmacology is a new and effective method, which changes the dogma of “one disease-one target-one drug”, and designs and analyses multi-target drug molecules to elaborate the mechanism of drug actions [ 30 ] in diseases such as diabetic nephropathy [ 31 ] and T-cell acute lymphoblastic leukemia [ 32 ].…”

Section: Discussionmentioning

confidence: 99%

Mechanistic Investigation of Curcuma Protection against Oral Submucous Fibrosis

Peng

Jiang

Cui

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Objective. Oral submucous fibrosis (OSMF) is a chronic, fibrotic disease that affects the oral cavity, showing a high rate of malignant transformation. Curcuma exerts therapeutic potentials in many diseases including OSMF. However, the potential targets and pathways to explain the therapeutic effects of curcuma on OSMF are outside the scope of present knowledge. Herein we intend to reveal the predictive targets and potential pathways of curcuma against OSMF by a network pharmacology-based approach followed by molecular docking technology. Methods. We searched the SymMap, GeneCards, and OMIM database to obtain curcuma and OSMF common targets. The protein-protein interaction (PPI) of curcuma and OSMF common targets were then analyzed, followed by functional enrichment analysis. The best binding mode of curcuma and target proteins was analyzed by molecular docking technology. Results. We collected 290 putative targets of curcuma molecules and 600 known therapeutic targets of OSMF, with 64 curcuma and OSMF common targets sorted out. In the PPI network, there were 63 nodes with 922 edges. The node indicates protein and the line indicates PPI relation. The most enriched GO term in the BP level is “gland development”, followed by “cellular response to chemical stress”, and then “response to oxygen levels”, while the most enriched GO term in CC and MF is “membrane raft” and “cytokine receptor binding”, respectively. We also found 131 KEGG pathways significantly enriched by curcuma and OSMF common targets. The binding energy of curcuma to ALB, TNF, TP53, IL6, and VEGFA was −9.5 kcal/mol, −3.9 kcal/mol, −3.5 kcal/mol, −3.6 kcal/mol, and −8.9 kcal/mol, respectively, which suggested ALB and VEGFA were regarded as main targets involving in the potential mechanism of curcuma against OSMF. Conclusion. The present study illustrated that the therapeutic effects of curcuma on OSMF were achieved by targeting ALB and VEGFA, which giving reference to further drug design and development for OSMF.

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“…Other studies suggest that the anti-inflammatory mechanism may be due to blocking the metabolism of arachidonic acid, with the following phenomena: selective inhibition of prostaglandin E2 and thromboxane synthesis, inhibition of arachidonic acid metabolism by lipoxygenase, elimination of the generated free radicals, and down-regulation of inflammatory cytokine expression IL-1β and IL-6 [ 42 , 43 ]. Curcumin also inhibits the release and regulation of several matrix metalloproteinases (MMPs) and reduces the release of many proteolytic enzymes, such as elastase, collagenase, and hyaluronidase, from activated macrophages [ 44 , 45 ].…”

Section: Properties Of Curcuminmentioning

confidence: 99%

Curcumin as a Natural Approach of Periodontal Adjunctive Treatment and Its Immunological Implications: A Narrative Review

et al. 2022

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Scaling and root planing represent the gold standard in the treatment of periodontal disease, but these therapeutic methods cannot eliminate the remaining periodontopathogenic bacteria in cement, tubules, and periodontal soft tissue. Thus, a number of additional therapeutic means have been adopted, including local and systemic antibiotic therapy, as well as the use of photodynamic therapy techniques. Recently, special attention has been paid to potential phytotherapeutic means in the treatment of periodontal disease. In this review, we aim to present the effects generated by the extract of Curcuma longa, the various forms of application of turmeric as an additional therapeutic means, as well as the aspects related to its biotolerance.

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Antimetastatic Effects of Curcumin in Oral and Gastrointestinal Cancers

Cited by 27 publications

References 211 publications

Curcumin analog HO‐3867 triggers apoptotic pathways through activating JNK1/2 signalling in human oral squamous cell carcinoma cells

Curcumin analog HO‐3867 triggers apoptotic pathways through activating JNK1/2 signalling in human oral squamous cell carcinoma cells

Mechanistic Investigation of Curcuma Protection against Oral Submucous Fibrosis

Curcumin as a Natural Approach of Periodontal Adjunctive Treatment and Its Immunological Implications: A Narrative Review

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