Antimicrobial action of zinc oxide nanoparticles in combination with ciprofloxacin and ceftazidime against multidrug-resistant Acinetobacter baumannii

Ghasemi, Faeze; Jalal, Razieh

doi:10.1016/j.jgar.2016.04.007

Cited by 90 publications

(50 citation statements)

References 14 publications

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“…Acinetobacter baumannii, an opportunistic pathogen that causes human pneumonia and meningitis, was used to analyze the effectiveness of ZnO in combination with conventional antibiotics, such as ciprofloxacin and ceftazidime. [70] From these studies, it was found that for both ciprofloxacin and ceftazidime, ZnO NPs in a sub-inhibitory concentration exhibited enhanced antibacterial activity. This was ascribed to the increased uptake of antibiotics and change in the morphology of bacterial cells due to the presence of ZnO NPs.…”

Section: Antimicrobial Activity and Its Mechanismmentioning

confidence: 99%

ZnO Nanostructures in Active Antibacterial Food Packaging: Preparation Methods, Antimicrobial Mechanisms, Safety Issues, Future Prospects, and Challenges

Kim

Karthika

Gopinath

et al. 2020

Food Reviews International

255

119

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Packaging of food products is one of the most important stages of the food supply chain. Nano-size materials for packing food substances with appropriate properties result in better packaging performance and longer food shelf-life. In this review, the application of ZnO nano-size in active packaging of foods is discussed to identify gaps in applications for food packaging and safety. First, the crystal structures and morphologies of modified ZnO nanoparticles (ZnO NPs) are presented, and their synergistic effects on antimicrobial activities are discussed. This review also provides an overview of antimicrobial packaging containing ZnO NPs with a focus on preparation methods, antimicrobial mechanisms, and recent progress in packaging applications. The generation of reactive oxygen species (ROS) is the primary antimicrobial mechanism, which can be varied depending on morphology and size. Generally, ZnO NPs can inactivate fungi or Gram-positive and Gram-negative bacteria growth, which reduce the risk of cross-contamination, thereby extending the shelf life of products. Notably, the health concerns and hazards regarding the safety and migration of ZnO NPs application are also elaborated. Unintentional migration, inhalation, skin penetration, and ingestion may result in human health hazards. Therefore, to provide safety regulations, further investigations such as case by case study are recommended. KEYWORDSZinc oxide nanostructure; shelf life; safety; antimicrobial activity; food packaging CONTACT Jongchul Seo

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Section: Antimicrobial Activity and Its Mechanismmentioning

confidence: 99%

ZnO Nanostructures in Active Antibacterial Food Packaging: Preparation Methods, Antimicrobial Mechanisms, Safety Issues, Future Prospects, and Challenges

Kim

Karthika

Gopinath

et al. 2020

Food Reviews International

255

119

View full text Add to dashboard Cite

show abstract

“…ZnO-NPs have the ability to inhibit bacterial growth and biofilm formation by inducing oxidative stress that can irreversibly damage cell membrane, DNA as well as mitochondria leading to apoptosis [24]. In 2016, Ghasemi and Jalal in their publication also investigated the synergistic effects of ZnO-NPs with conventional antibiotics against resistant Acinetobacter baumannii [25] and reported that the uptake of antibiotics into bacterial cell increased with the addition of ZnO-NPs [25].…”

Section: Introductionmentioning

confidence: 99%

Cytotoxicity and antibacterial activities of plant-mediated synthesized zinc oxide (ZnO) nanoparticles using Punica granatum (pomegranate) fruit peels extract

Sukri

Shameli

Wong

et al. 2019

Journal of Molecular Structure

179

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The unique properties of zinc oxide nanoparticles (ZnO-NPs) produced using plant extract make them attractive for use in medical as well as industrial applications, and it is necessary to develop environmentally friendly methods for their synthesis. This can be accomplished by replacing the traditional chemical compounds for the reduction of the zinc ions to ZnO-NPs during synthesis with natural plant extracts. Here, the biosynthesis of ZnO-NPs using Punica granatum (P. granatum) fruit peels extract was investigated as the reducing and stabilizing agent. The P. granatum/ZnO-NPs with spherical and hexagonal shapes were biosynthesized at different annealing temperatures. The X-ray diffraction analysis confirmed the synthesis of highly pure ZnO-NPs with increasing crystallinity in higher annealing temperatures. The ZnO-NPs displayed characteristic absorption peaks between 370 and 378 nm in the UV evis spectra. Transmission electron microscopy (TEM) imaging showed the formation of mostly spherical and hexagonal-shaped ZnO-NPs in the mean size of 32.98 nm and 81.84 nm at 600 C and 700 C respectively. According to FTIR spectrum, strong absorption bands in the range of 462e487 cm À1 corresponding to ZneO bond stretching can be seen. Antibacterial activities of P. granatum/ZnO-NPs against Escherichia coli (E. coli) and Enterococcus faecalis (E. faecalis) were investigated and compared. Results obtained show that smaller-sized P. granatum/ZnO-NPs are more effective in inhibiting growth of both bacteria. In addition, cytotoxicity assays were performed for P. granatum/ZnO-NPs against human colon normal and cancerous cells. P. granatum/ZnO-NPs exhibited similar killing activities of both cell lines at the concentration of !31.25 mg/mL. The biosynthesized ZnO-NPs could offer potential applications in biomedical field.

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“…An improved antimicrobial effect is attributed to the synergistic interactions from the ZnO core and the released ampicillin molecules . ZnO‐generated reactive oxygen species (ROS) caused membrane disruption, which, in turn, resulted in a higher uptake of antibiotic molecules within the bacterial lumen, causing cell death . Even in case of drug (antibiotic) resistant bacteria, which often evolves efflux pumps to actively push out antibiotic molecules, the oxidative damage through ZnO can be expected to create leaky bacterial membranes thereby causing a higher influx of antibiotic molecules .…”

Section: Resultsmentioning

confidence: 99%

Synergistic Antimicrobial Activity in Ampicillin Loaded Core‐Shell ZnO@ZIF‐8 Particles

et al. 2019

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Combination therapy with the use of nanomaterials and antibiotics is an effective approach to combat increasing antimicrobial resistance. Herein, the synthesis and antimicrobial activity of core‐shell Zinc oxide ‐ Zeolitic Imidazolate Framework‐8 (ZnO@ZIF‐8) particles loaded with ampicillin is reported. The efficacy of the above system has been evaluated against Gram‐negative Escherichia coli (E. coli) and Gram‐positive Staphylococcus aureus (S. aureus) strains. The entrapment of ampicillin within the ZIF‐8 shell of the particles allowed its controlled and pH‐responsive release under in vitro conditions. Ampicillin loaded ZnO@ZIF‐8 particles have exhibited enhanced antimicrobial activity as reflected by the minimum inhibitory concentration (MIC) values of 12.50 and 48 μg mL−1 against E. coli and S. aureus, respectively. This was also evident by a several‐fold reduction observed in the bacterial population during the time‐kill assays. The values of fractional inhibitory concentration indices (FICI), assessed for different components, have revealed the ZnO@ZIF‐8/ampicillin system inflicts a synergistic activity against E. coli and an additive activity against S. aureus. Cell membrane disruption is attributed to cell death. Finally, cytotoxicity study against mammalian cell lines has indicated the safety profiles of the particles.

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Antimicrobial action of zinc oxide nanoparticles in combination with ciprofloxacin and ceftazidime against multidrug-resistant Acinetobacter baumannii

Cited by 90 publications

References 14 publications

ZnO Nanostructures in Active Antibacterial Food Packaging: Preparation Methods, Antimicrobial Mechanisms, Safety Issues, Future Prospects, and Challenges

ZnO Nanostructures in Active Antibacterial Food Packaging: Preparation Methods, Antimicrobial Mechanisms, Safety Issues, Future Prospects, and Challenges

Cytotoxicity and antibacterial activities of plant-mediated synthesized zinc oxide (ZnO) nanoparticles using Punica granatum (pomegranate) fruit peels extract

Synergistic Antimicrobial Activity in Ampicillin Loaded Core‐Shell ZnO@ZIF‐8 Particles

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