Antimicrobial actions of dual oxidases and lactoperoxidase

Sarr, Demba; Tóth, Eszter; Gingerich, Aaron D.; Rada, Balázs

doi:10.1007/s12275-018-7545-1

Cited by 73 publications

(70 citation statements)

References 173 publications

(228 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, overproduction of H 2 O 2 could lead to oxidative stress resulting in oxidative injuries and mucosal barrier impairment [20]. In addition to its role in the persistent and recurrent inflammatory of UC, the DUOXA2/DUOX2 pathway is also involved in the development of UC-associated adenomas and colorectal cancer [21][22][23]. We supposed that SLC6A14 and DUOXA2 aberrantly expressed might promote the initiation and development of UC.…”

Section: Discussionmentioning

confidence: 99%

Investigation of Potential Genetic Biomarkers and Molecular Mechanism of Ulcerative Colitis Utilizing Bioinformatics Analysis

Zhang

Wang

et al. 2020

BioMed Research International

View full text Add to dashboard Cite

Objectives. To reveal the molecular mechanisms of ulcerative colitis (UC) and provide potential biomarkers for UC gene therapy. Methods. We downloaded the GSE87473 microarray dataset from the Gene Expression Omnibus (GEO) and identified the differentially expressed genes (DEGs) between UC samples and normal samples. Then, a module partition analysis was performed based on a weighted gene coexpression network analysis (WGCNA), followed by pathway and functional enrichment analyses. Furthermore, we investigated the hub genes. At last, data validation was performed to ensure the reliability of the hub genes. Results. Between the UC group and normal group, 988 DEGs were investigated. The DEGs were clustered into 5 modules using WGCNA. These DEGs were mainly enriched in functions such as the immune response, the inflammatory response, and chemotaxis, and they were mainly enriched in KEGG pathways such as the cytokine-cytokine receptor interaction, chemokine signaling pathway, and complement and coagulation cascades. The hub genes, including dual oxidase maturation factor 2 (DUOXA2), serum amyloid A (SAA) 1 and SAA2, TNFAIP3-interacting protein 3 (TNIP3), C-X-C motif chemokine (CXCL1), solute carrier family 6 member 14 (SLC6A14), and complement decay-accelerating factor (CD antigen CD55), were revealed as potential tissue biomarkers for UC diagnosis or treatment. Conclusions. This study provides supportive evidence that DUOXA2, A-SAA, TNIP3, CXCL1, SLC6A14, and CD55 might be used as potential biomarkers for tissue biopsy of UC, especially SLC6A14 and DUOXA2, which may be new targets for UC gene therapy. Moreover, the DUOX2/DUOXA2 and CXCL1/CXCR2 pathways might play an important role in the progression of UC through the chemokine signaling pathway and inflammatory response.

show abstract

Section: Discussionmentioning

confidence: 99%

Investigation of Potential Genetic Biomarkers and Molecular Mechanism of Ulcerative Colitis Utilizing Bioinformatics Analysis

Zhang

Wang

et al. 2020

BioMed Research International

View full text Add to dashboard Cite

show abstract

“…Under normal conditions, most NOX isoforms have very low or no constitutive activity but their expression can be increased after pathogens' invasion. Under these conditions, the activated NOXs can generate high ROS levels leading to increased oxidative stress (Sarr et al, 2018). Oxidative stress commonly is used as a defense mechanism for killing foreign microorganisms (Xiong et al, 2018).…”

Section: Dual Oxidase Is a Member Of Nadph Oxidasesmentioning

confidence: 99%

Mini review: immunologic functions of dual oxidases in mucosal systems of vertebrates

2020

View full text Add to dashboard Cite

Mucosal epithelial cells act as the first immunologic barrier of organisms, and contact directly with pathogens. Therefore, hosts must have differential strategies to combat pathogens efficiently. Reactive oxygen species (ROS), as a kind of oxidizing agents, participates in the early stage of killing pathogens quickly. Recent reports have revealed that dual oxidase (DUOX) plays a key role in mucosal immunity. And the DUOX is a transmembrane protein which produces ROS as their primary enzymatic products. This process is an important pattern for eliminating pathogens. In this review, we highlight the DUOX immunologic functions in the respiratory and digestive tract of vertebrates.

show abstract

“…Lactoperoxidase was found in mucosal surfaces and exocrine secretions including milk, tears, and saliva, and in nasal and lung airway fluids. LPO is a major contributor to airway defenses and to the antimicrobial properties of exocrine gland secretions [ 33 , 36 , 138 , 139 ].…”

Section: Eosinophil Peroxidase and Lactoperoxidasementioning

confidence: 99%

Peroxidase Activity of Human Hemoproteins: Keeping the Fire under Control

Vlasova

2018

Molecules

114

View full text Add to dashboard Cite

The heme in the active center of peroxidases reacts with hydrogen peroxide to form highly reactive intermediates, which then oxidize simple substances called peroxidase substrates. Human peroxidases can be divided into two groups: (1) True peroxidases are enzymes whose main function is to generate free radicals in the peroxidase cycle and (pseudo)hypohalous acids in the halogenation cycle. The major true peroxidases are myeloperoxidase, eosinophil peroxidase and lactoperoxidase. (2) Pseudo-peroxidases perform various important functions in the body, but under the influence of external conditions they can display peroxidase-like activity. As oxidative intermediates, these peroxidases produce not only active heme compounds, but also protein-based tyrosyl radicals. Hemoglobin, myoglobin, cytochrome c/cardiolipin complexes and cytoglobin are considered as pseudo-peroxidases. Рeroxidases play an important role in innate immunity and in a number of physiologically important processes like apoptosis and cell signaling. Unfavorable excessive peroxidase activity is implicated in oxidative damage of cells and tissues, thereby initiating the variety of human diseases. Hence, regulation of peroxidase activity is of considerable importance. Since peroxidases differ in structure, properties and location, the mechanisms controlling peroxidase activity and the biological effects of peroxidase products are specific for each hemoprotein. This review summarizes the knowledge about the properties, activities, regulations and biological effects of true and pseudo-peroxidases in order to better understand the mechanisms underlying beneficial and adverse effects of this class of enzymes.

show abstract

Antimicrobial actions of dual oxidases and lactoperoxidase

Cited by 73 publications

References 173 publications

Investigation of Potential Genetic Biomarkers and Molecular Mechanism of Ulcerative Colitis Utilizing Bioinformatics Analysis

Investigation of Potential Genetic Biomarkers and Molecular Mechanism of Ulcerative Colitis Utilizing Bioinformatics Analysis

Mini review: immunologic functions of dual oxidases in mucosal systems of vertebrates

Peroxidase Activity of Human Hemoproteins: Keeping the Fire under Control

Contact Info

Product

Resources

About