Antimicrobial Activities against 84 Listeria monocytogenes Isolates from Patients with Systemic Listeriosis at a Comprehensive Cancer Center (1955-1997)

Abstract

Listeriosis is a serious complication in patients undergoing treatment for cancer. We present antimicrobial susceptibility profiles of 84 clinical Listeria monocytogenes isolates. During 1955 to 1997, in vitro susceptibility for penicillin (97.6%), ampicillin (90.7%), erythromycin (98.8%), tetracycline (96.9%), and gentamicin (98.0%) remained unchanged. All isolates were susceptible to amikacin, ciprofloxacin, imipenem, rifampin, trimethoprim-sulfamethoxazole (TMP-SMX), and vancomycin. High prevalence of clindamycin resistance (96.2%) was unexpected. Ampicillin plus gentamicin is standard therapy for systemic listerosis, and TMP-SMX may be used for patients with beta-lactam intolerance. In vitro susceptibility profiles for carbapenem and fluoronated quinolone are promising, although clinical validation is critically needed before routine use is advocated, especially for listeric patients with severe cellular immune defects.

Multiple Antibiotic Resistance among Listeria Strains, Including Listeria monocytogenes Isolated from Animals of Gujarat State, India

“…Willayat et al, (2005) reported L. monocytogenes isolates was highly sensitive to gentamicin but resistant to tetracycline, ampicillin, amoxycillin and chloramphenicol. The findings of the various authors (Phadke et al, 1979;Shah and Dolakia, 1983;Sharda et al, 1991;Walsh et al, 2001;Safdar and Armstrong, 2003) were in partial agreement with the present investigation. Kumar et al, (2005) reported multidrug resistant Listeria from meats and fish.…”

Detection and characterization of tet(M) in tetracycline-resistant Listeria strains from human and food-processing origins in Belgium and France

“…The emergence of such resistant strains has highlighted the need for surveillance programmes to monitor temporal and geographical shifts in resistance patterns and the associated phenotypes and genotypes (Safdar & Armstrong, 2003). Emergence of resistance is not only the case for L. monocytogenes but also for other Listeria species such as Listeria innocua that can occur in similar habitats (e.g.…”

“…This disease has been associated with mortality rates of up to 30 % in infants and in patients with underlying diseases (Hof et al, 1997). Standard antibiotic therapy for the effective treatment of listeriosis consists of the administration of either ampicillin or penicillin G whereas, for established infections, aminoglycosides can be used in combination with penicillins (Safdar & Armstrong, 2003).…”

Antimicrobial Susceptibilities of Listeria monocytogenes Isolated from the Imported and the Domestic Foods in Japan

“…In another study in Japan, one isolate from the feces of patient cow was resistant to GM (Hara, 1983). GM-resistant isolates were isolated from several countries; from 60.9 % (14/23) of dairy products in Spain (Rota, 1996), 42.9% (3/7) of milk in India (Bhilegaonkar, 1997), 2% (1/52) of cancer patients in USA (Safdar, 2003), 4.6% (2/43) of foods in Poland (Majczyna, 2006). Zamora et al described that 15% (3 of 20) of clinical isolates were resistant to GM in Costa Rica (Zamora, 2006).…”