Antimicrobial activities of Alstonia boonei stem bark, a Nigerian traditional medicinal plant

Ogueke, Chika C.; Uwaleke, Joachim; Owuamanam, Clifford I.; Okolue, B.N.

doi:10.1016/s2222-1808(14)60766-0

Cited by 7 publications

(6 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Voucher specimens were deposited and voucher numbers were issued as UILH/002/558 and UILH/002/559. The leaves were thoroughly washed with clean water and air dried for fourteen days at room temperature after which they were pulverized into powdery forms according to Ogueke et al (2014). The phytochemical and proximate analyses of these plants have been done in our previous studies (Ajadi et al, 2021;Ajadi et al, 2022).…”

Section: Sources and Identi Cation Of Plantsmentioning

confidence: 99%

“…Plants and other phytogenic agents have been found among other better alternatives as sh growth promoters and to enhance virile immunity and protection against infectious diseases (Abdel-latif et al, 2020). Alstonia boonei and Mitracarpus scaber are essential natural agents that have been reported to contain antimicrobial properties against myriads of infections ( Owolabi et al, 2013;Ogueke et al, 2014;Ajadi et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

“…boonei has been widely used in the terrestrial animals for the treatment of various diseases due to the presence of bioactive components in all parts of the plant. Studies have shown that the plant has antiin ammatory, anti-venom, anti-poison and antimicrobial properties and a potent compound in the treatment of ulcers which is commonly found in aeromonas infection (Akinmoladun et al, 2007;Ogueke et al, 2014;Ikechukwu et al, 2021). In the same vein, M. scaber also contains bioactive ingredients that are used as therapeutic agents and feed additives.…”

Section: Introductionmentioning

confidence: 99%

“…A. boonei(Ogueke et al, 2014;Opoku & Osei, 2014) and M. scaber(Adeshina et al, 2019(Adeshina et al, , 2021Ajadi et al, 2021) have been reported to contain bioactive components such as such as avonoids, alkaloids, phenols, saponins, tannins among other aromatic compounds that play important roles in defence mechanism against microbial organisms. This is evident in this…”

mentioning

confidence: 99%

See 3 more Smart Citations

Protective Evaluation of feed fortified with Alstonia boonei and Mitracarpus scaber in African Catfish exposed to Aeromonas hydrophila: Clinicopathology and immunohistochemistry

Ajadi

Jarikre

Jibril

et al. 2022

Preprint

View full text Add to dashboard Cite

The present study was carried out to determine the protective effects of two dietary plants and the associated pathology in African catfish exposed to A. hydrophila. Four hundred and twenty fish with average weight of 20.53 ± 0.15 g were distributed equally (in triplicates) into seven experimental groups (six treatment groups and a control group) with 20 juvenile African catfish in each aquarium. Fish were fed for 84 days with control and six other experimental diets containing different percentages of Alstonia boonei (0.5%,1.0% and 1.5%) and Mitracarpus scaber (0.5%,1.0% and 1.5%) of the basal diets. At the end of 12th week, the fish were challenged with A. hydrophila and clinical signs and mortality rate were observed for fourteen days post challenge. Blood and tissue samples were collected for analysis. All the groups fed with plant supplemented feed had 100% survival rate except A. boonei (0.5%) with 85% and control had 70% survival rate. The dietary plants also improved the haematological parameters and reduced the histopathological lesions associated with A. hydrophila exposure, compared to the control. The findings have demonstrated the protective potentials of A. boonei and M. scaber inculcated in feed against A. hydrophila infection in African catfish

show abstract

Section: Sources and Identi Cation Of Plantsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

Protective Evaluation of feed fortified with Alstonia boonei and Mitracarpus scaber in African Catfish exposed to Aeromonas hydrophila: Clinicopathology and immunohistochemistry

Ajadi

Jarikre

Jibril

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

“…An aqueous fraction of 70% methanol extract of A. boonei leaves demonstrated significant anti-inflammatory and antioxidant activities in carrageenan and formaldehyde-induced arthritic rats [ 1 ]. A. boonei stem bark ethanol extract showed inhibitory action against Escherichia coli [ 6 ]. The ethyl acetate extract of A. boonei leaves showed potent inhibitory activity against key enzymes targeted in the management of diabetes type II, namely, α-amylase (IC 50 : 3.17 mg/mL) and α-glucosidase (IC 50 : 0.70 mg/mL).…”

Section: Introductionmentioning

confidence: 99%

A Study on Chemical Characterization and Biological Abilities of Alstonia boonei Extracts Obtained by Different Techniques

et al. 2022

View full text Add to dashboard Cite

In the quest for novel therapeutic agents from plants, the choice of extraction solvent and technique plays a key role. In this study, the possible differences in the phytochemical profile and bioactivity (antioxidant and enzyme inhibitory activity) of the Alstonia boonei leaves and stem bark extracted using water, ethyl acetate and methanol, and different techniques, namely infusion, maceration and Soxhlet extraction, were investigated. Data collected showed that methanol extracts of both A. boonei leaves (48.34–53.08 mg gallic acid equivalent [GAE]/g dry extract) and stem bark (37.08–45.72 mg GAE/g dry extract) possessed higher phenolic content compared to the ethyl acetate extracts (leaves: 30.64–40.19 mg GAE/g; stem bark: 34.25–35.64 mg GAE/g). The methanol extracts of A. boonei leaves showed higher radical scavenging and reducing capacity, and these findings were in accordance with phenolic content results. In general, water extracts of A. boonei leaves and stem bark obtained by infusion were poor inhibitors of acetylcholinesterase, α-amylase, α-glucosidase, and tyrosinase, except for butyrylcholinesterase. The chemical profiles of the extracts were determined by UHPLC–MS and the presence of several compounds, such as phenolic acids (caffeic, chlorogenic and ferulic acids, etc.), flavonoids (rutin and isoquercetin) and flavonolignans (Cinchonain isomers). Cell viability was tested using the human peripheral blood monocytic cell line (THP-1), and the extracts were safe up to 25 μg/mL. In addition, anti-inflammatory effects were investigated with the releasing of IL-6 TNF-α and IL-1β. In particular, stem bark extracts exhibited significant anti-inflammatory effects. Data presented in this study highlight the key role of solvent choice in the extraction of bioactive secondary metabolites from plants. In addition, this study appraises the antioxidant and enzyme inhibitory action of A. boonei leaves and stem bark, which are extensively used in traditional medicine.

show abstract

Antibacterial, Antifungal, and Antiviral Properties of Medical Plants

Jabborova

Davranov

Egamberdieva

2019

Microorganisms for Sustainability

View full text Add to dashboard Cite

Antimicrobial activities of Alstonia boonei stem bark, a Nigerian traditional medicinal plant

Cited by 7 publications

References 29 publications

Protective Evaluation of feed fortified with Alstonia boonei and Mitracarpus scaber in African Catfish exposed to Aeromonas hydrophila: Clinicopathology and immunohistochemistry

Protective Evaluation of feed fortified with Alstonia boonei and Mitracarpus scaber in African Catfish exposed to Aeromonas hydrophila: Clinicopathology and immunohistochemistry

A Study on Chemical Characterization and Biological Abilities of Alstonia boonei Extracts Obtained by Different Techniques

Antibacterial, Antifungal, and Antiviral Properties of Medical Plants

Contact Info

Product

Resources

About