Antimicrobial activities of amphiphilic cationic polymers and their efficacy of combination with novobiocin

Miyagawa, Atsushi; Ohno, Shinya; Hattori, Tsuyoshi; Yamamura, Hisao

doi:10.1080/09205063.2021.1985243

Cited by 2 publications

(2 citation statements)

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“…Recently, we synthesized antimicrobial polymers containing cationic amino hexyl monomers and low-hydrophobic isopropyl monomers, which exhibited low antimicrobial activities against Staphylococcus aureus and E. coli. 20 Therefore, the polymers were combined with novobiocin, a coumarin antibiotic that inhibits the ATPase activity of DNA gyrase. Here, novobiocin demonstrated an antimicrobial activity specifically against gram-positive bacteria.…”

Section: Introductionmentioning

confidence: 99%

“…However, antimicrobial polymers usually exhibit lower antimicrobial activities against bacteria compared to antimicrobial peptides. Recently, we synthesized antimicrobial polymers containing cationic amino hexyl monomers and low‐hydrophobic isopropyl monomers, which exhibited low antimicrobial activities against Staphylococcus aureus and E. coli 20 . Therefore, the polymers were combined with novobiocin, a coumarin antibiotic that inhibits the ATPase activity of DNA gyrase.…”

Section: Introductionmentioning

confidence: 99%

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Synthesis of antimicrobial polymers with mannose residues as binders for the FimH adhesin of Escherichia coli

Miyagawa

Ohno

Yamamura

2022

Journal of Polymer Science

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Recently, antimicrobial polymers have been developed as novel antibiotics, and they are beneficial for human health. An advantage of these polymers is that they can be easily functionalized via the addition or modification of monomers. In this study, to enhance the bacterial selectivity and antimicrobial activity of a polymer, mannose monomers were copolymerized with aminopropyl monomers and isoalkyl monomers. These mannose monomers were found to mimic the mannan and N‐glycan moieties on mammalian cells interacting with the FimH adhesin of Escherichia coli. A mannose monomer with a short ethyl linker did not enhance the antimicrobial activity (minimum inhibitory concentration (MIC): 32 μg/ml) against E. coli; however, that with a longer hexyl linker enhanced the antimicrobial activity (MIC: 16 μg/ml) against E. coli selectivity (no effect on Staphylococcus aureus was observed). Further, the polymer containing the hexyl mannose residue did not develop resistance in E. coli after 15 passages. Consequently, polymers with mannose units, which have a high affinity for the FimH adhesin, can serve as effective and selective antimicrobial agents against E. coli.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%