Antimicrobial Activities of Biimidazole Based Mixed Ligand Ruthenium(ii) Complexes

Abstract

Ruthenium(II) complexes of the type [Ru(bpy)2(L)](PF6)2, where L=4,5-bis(4-dimethyaminophenyl)-1H,1'H-2,2'-biimidazole (1) and 4,5-bis(4fluorophenyl)-1H,1'H-2,2'-biimidazole (2) that combine the structure of bipyridine and substituted biimidazole derived from dimethylaminobenzil and fluorobenzil have been synthesized and characterized by elemental analyses and spectral (IR, UV-vis, EI-MS) techniques. The redox behavior of the complexes has been studied by cyclic and differential pulse voltammetry. The synthesized ligands and complexes have been tested for in vitro growth inhibitory activity against two Gram-positive bacteria (Staphylococcus aureus and Bacillus subtilis), two Gram-negative bacteria (Escherichia coli and Pseudomonas aeruginosa), and two fungi (Aspergillus niger and Candida albicans). The antimicrobial activities of the complexes showed better activity compared to that of the ligands.

Binding Studies of Ruthenium(II) Polypyridyl Complexes with Quinones in Triton X-100

“…Ruthenium complexes of various ligands have attracted great interest as alternative drugs to cisplatin in cancer therapy. The significant structural differences between ruthenium and most platinum have antitumour drugs give a promising alternative to cisplatin and carboplatin 9 . Among the transition metal complexes, ruthenium(II) polypyridyl complexes [Ru(NN) 3 ] 2+ have particularly drawn significant interest to develop new therapeutic agents.…”