Antimicrobial activities of Carica papaya leaf against diarrhoea causing agents

Abstract

The advent of science to the search for antibiotics principally depends on medicinal plants as raw materials. This present study evaluated the antimicrobial effect of Carica papaya leaf extracts against bacterial and fungal agents that causes diarrhoea. Fresh tender roots and leaves of this plant was collected, air-dried, powdered and percolated in n-hexane, methanol and aqueous solvents. The antimicrobial activities of the extract against test organisms were tested by using agar well diffusion assay and the MIC, MBC and MFC values were determined by agar dilution assay. The results revealed that the crude methanol and aqueous extracts of Carica papaya had no anti-fungal activity, but have antibacterial activity. N.hexane extract of C. papaya had most activity than other solvents with MIC ranged from 25 mg/ml to 50 mg/ml and MBC ranged from 50 mg/ml to 100 mg/ml.These results suggest that paw paw leaf extract is recommended as a diarrhoea disease remedy.

Exploring the Antidiarrheal Properties of Papaya Leaf: Insights In Vivo Study in Mice‐Model and In Silico Analysis at M3 Muscarinic Acetylcholine Receptor Interaction

“…The study conducted by Unaeze et al, 2018, reported that papaya leaf extract has a minimum inhibitory concentration and minimum bactericidal concentration of 25 to 50 mg/mL and 50 to 100 mg/mL, respectively. These results show that papaya leaves are recommended as an antidiarrheal remedy [ 33 ].…”

Study of the Antimicrobial Activity and Synergistic Inhibitory Activity of Carica papaya leaves extract with Antibiotics on Escherichia coli

“…[18] Earlier Atta F have proven antibacterial property of Carica papaya leaves. [19] Also Ajiboye et al in their study have found potential antimicrobial property of Carica papaya. [20] Earlier Unazae et al have found antibacterial activity of Carica papaya leaf extract in E. coli.…”

Pengaruh Pemberian Larutan Daun Pepaya Pada Lele yang Diinfeksi Aeromonas hydrophila Ditinjau dari Histopatologi Insang, Kulit, dan Otot

“…Daun papaya merupakan salah satu bahan yang digunakan dalam pengobatan tradisional. Menurut Unaeze (2018), ekstrak methanol daun papaya selain memiliki senyawa fenol (asam protocatechuic, asam pcoumaric, 5,7-dimethoxycoumarin, asam kafeik, kaempferol, kuersetin dan asam klorogenik) juga banyak memiliki metabolit sekunder lainnya. Senyawa utama dalam tumbuhan papaya adalah chymopapain dan papain, yang membantu pencernaan.…”