Antimicrobial Activities of Hexane Extract and Decussatin from Stembark Extract of Ficus congensis

Alaribe, Chinwe S.; Shode, Francis O.; Coker, H. A. B.; Ayoola, Gloria A.; Sunday, Adesegun; Singh, Nisha; Iwuanyanwu, Silva

doi:10.3390/ijms12042750

Cited by 11 publications

(10 citation statements)

References 11 publications

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“…The MIC values of the dichloromethane extract are not shown in Figure 1, since the extract was not active against any of the bacterial strains. The hexane extract of the bark of A. mearnsii showed potent antibacterial activity against E. coli with MIC value of 10.0 mg/ml and the results were almost similar to those of hexane extracts of the bark of Ficus congensis reported by Alaribe et al (2011) with MIC values of 8.0 mg/ml.…”

Section: Resultssupporting

confidence: 78%

See 1 more Smart Citation

Antibacterial activity of the stem bark extracts of Acacia mearnsii De Wild

Mbolekwa¹,

Kambizi²,

Songca³

et al. 2014

Afr. J. Microbiol. Res.

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Antibacterial activity of four different extracts from the stem bark of Acacia mearnsii was measured against five Gram-positive and five Gram-negative bacterial strains: Staphylococcus aureus, Staphylococcus epidermidis, Bacillus cereus, Micrococcus kristinae, Streptococcus faecalis, Escherichia coli, Pseudomonas aeruginosa, Shigella flexneri, Klebsiella pneumonia and Serratia marcescens. The extracts assessed include hexane, ethyl acetate, dichloromethane and methanol. The hexane, ethyl acetate and methanol extracts showed some inhibitory effects on the selected bacteria. The hexane extract showed some activity against four Gram-positive and two Gram-negative bacterial strains, but was not active against one Gram-positive and three Gram-negative bacterial strains. The ethyl acetate extract was effective against all the bacterial strains used in this study. The methanolic extract was effective against all the Gram-positive bacterial strains but it was not active against the Gram-negative bacterial strains except Escherichia coli. The dichloromethane extract was not active at all against all the bacterial strains tested.

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Section: Resultssupporting

confidence: 78%

“…According to Alaribe et al (2011) the same bacterial species was not inhibited by the extract. In this study, the hexane extract showed activity against four Grampositive bacterial strains with MIC value of 10.0 mg/ml but was not active against S. faecalis.…”

Section: Resultsmentioning

confidence: 93%

Antibacterial activity of the stem bark extracts of Acacia mearnsii De Wild

Mbolekwa¹,

Kambizi²,

Songca³

et al. 2014

Afr. J. Microbiol. Res.

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“…The need for new classes of safe and natural antimicrobials able to control the microorganism growth and infections has become more urgent [1]. Synthetic drugs have been associated with several side effects on human health.…”

Section: Introductionmentioning

confidence: 99%

“…Analysis of the antimicrobial activity of chemical constituents of the oils, alone or in combination, in different treatments using different microorganisms can produce lethal effects at lower doses, avoiding changes and providing various perspectives on the problem of bacterial resistance to antibiotics [1, 5]. …”

Section: Introductionmentioning

confidence: 99%

Study of the Interference betweenPlectranthusSpecies Essential Oils from Brazil and Aminoglycosides

Rodrigues

Costa

Rodrigues

et al. 2013

Evidence-Based Complementary and Alternative Medicine

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Plectranthus is one of the most representative genera of Lamiaceae family. In this study, the essential oils from Plectranthus amboinicus, Plectranthus ornatus, and Plectranthus barbatus were investigated for their chemical composition and antimicrobial and modulatory activities. The major components found were carvacrol (54.4%—P. amboinicus) and eugenol (22.9%—P. ornatus e 25.1%—P. barbatus). In vitro antimicrobial activity was conducted against Escherichia coli, Proteus vulgaris, Bacillus cereus, Pseudomonas aeruginosa, Staphylococcus aureus, and Staphylococcus aureus (multiresistant) using microdilution method. The results of bioassay showed that all strains were sensitive to the oils, except P. aeruginosa that was resistant to P. amboinicus and P. ornatus. A synergistic effect of all essential oils combined with the aminoglycosides was demonstrated. These results show that P. amboinicus, P. ornatus, and P. barbatus inhibit the growth of pathogenic microorganism, and besides this they present antibiotic modifying activity, providing a new perspective against the problem of bacterial resistance to antibiotics.

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“…Flavonoids A-D were yellow needle-like crystals with the following molecular weights: A, 302 g/mol; B, 302 g/mol; C, 288 g/mol and D, 288 g/mol. The four flavonoids were extracted and synthesized at the Inner Mongolia Medical University (Hohhot, China) (15), and uniformly mixed into the basic feeds of the experimental rats. Anti-FAS (MHCD9528) was purchased from Thermo Fisher Scientific, Inc. (Carlsbad, CA, USA), and anti-phospho AMPK (AA393), anti-AMPK (AA393-1; Beyotime Institute of Biotechnology, Shanghai, China), and horseradish peroxidase-conjugated anti-mouse (NCAM-1/CD56; R&D Systems, Inc., Minneapolis, MN, USA) and anti-rabbit (ab191866) antibodies were purchased from Abcam (Cambridge, UK).…”

Section: Methodsmentioning

confidence: 99%

Hypolipidemic effects of flavonoids extracted from Lomatogonium rotatum

Zhang

Wang

2016

Experimental and Therapeutic Medicine

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Abstract. Contained in the Mongolian volumes of Chinese Materia Medica, Lomatogonium rotatum Fries ex Nym. may reduce blood lipid levels and prevent obesity; however, its exact mechanism of action remains unclear. The present study investigated the hypolipidemic and obesity-inhibiting effects of four similarly structured flavonoids extracted from L. rotatum. According to a well-established method, flavonoids such as decussatin were extracted from the whole herb of L. rotatum, and male Wistar rats were subsequently fed a high-fructose diet supplemented with flavonoids (20 mg/kg) for 12 weeks. The levels of total cholesterol, triglyceride (TG), low-density lipoprotein-cholesterol and high-density lipoprotein-cholesterol (HDL-C) were detected. In addition, hepatic and epididymal adipose tissues were weighed, and levels of blood glucose, alanine aminotransferase, aspartate aminotransferase, non-esterified fatty acid, insulin and leptin were determined. The mRNA expression levels of fatty acid synthase (FAS) were analyzed using a reverse transcription polymerase chain reaction; whereas FAS, adenosine monophosphate-activated protein kinase (AMPK) and threonine-172 phosphorylated AMPK protein levels were detected by western blotting. The epididymal adipose tissues of rats fed with flavonoids were lighter, as compared with those fed with fructose in the model group. Following a 12-week administration of flavonoids, the serum levels of fasting blood glucose, feeding blood glucose and leptin were decreased. Furthermore, flavonoid treatment reduced TG and cholesterol levels in the blood and increased serum HDL-C levels, as compared with the model group. High-fructose diet administration significantly increased FAS mRNA and protein expression levels, whereas the FAS protein levels of flavonoid-treated rats were markedly reduced.The flavonoid compounds also enhanced threonine-172 phosphorylation of AMPK in the liver lysate, and all flavonoids successfully downregulated leptin levels and the majority decreased the relative weights of epididymal adipose tissue. Therefore, flavonoids may function in a similar way to epigallocatechin gallate, which has previously been shown to inhibit FAS activity by stimulating AMPK in hepatocyte cells via the liver kinase B1 pathway.

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Antimicrobial Activities of Hexane Extract and Decussatin from Stembark Extract of Ficus congensis

Cited by 11 publications

References 11 publications

Antibacterial activity of the stem bark extracts of Acacia mearnsii De Wild

Antibacterial activity of the stem bark extracts of Acacia mearnsii De Wild

Study of the Interference betweenPlectranthusSpecies Essential Oils from Brazil and Aminoglycosides

Hypolipidemic effects of flavonoids extracted from Lomatogonium rotatum

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