Antimicrobial Activities of Medicinal Plants Containing Phenolic Compounds

Abstract

Background: Medicinal plants have been used to treat diseases for centuries. They are important sources in terms of their pharmacological effects and also have many microbial agents. Recently, the development of drug resistance has begun to spread in human pathogens against used antibiotic and this situation has led to the increasingly necessitating the new researches for novel antimicrobial substances from natural products containing plants. Objective: The purpose of this review is to determine the antimicrobial activity of pure phenolic compounds isolated from medicinal plants and to evaluate how molecular structures of these compounds affect the activity and also provide to the readers a source for future studies about natural antimicrobial agents. Methods: Relevant informations were gathered from scientific databases (Web of Science, Scifinder, Google Scholar, Science Direct, Wiley Online Library, PubMed, Taylor&Francis online) with using different keywords. Antimicrobial activity researches were selected especially on pure phenolic compounds. Results: Numerous phenolic compounds have been isolated from plants/plant extracts and these compounds are shown to prevent the growth of bacteria and fungi and their Minimum Inhibition Concentration and inhibition zone values were given in details. Conclusion: This review revealed that they have different antimicrobial activity according to the changes in molecular structure of phenolic compounds found in medicinal plants.

Polyphenolic Bioactive Compounds from Larrea tridentata (DC.) Coville: Extraction, Characterization, Antioxidant, and Antifungal Activities

“…These compounds are characterized by the presence of one or more hydroxyl (-OH) groups attached to a sixcarbon aromatic ring (Dikpınar & Süzgeç-Selçuk, 2020;Gulcin, 2020). Phenolic compounds are present either as unconjugated glycosides or bound to sugars, such as glucose, galactose, rhamnose, xylose, or arabinose in glycosidic forms (González-Sarrías et al, 2020).…”

Mineral Profile, Antioxidant, Anti-Inflammatory, Antibacterial, Anti-Urease and Anti-α-Amylase Activities of the Unripe Fruit Extracts of Pistacia atlantica

“…Phenolic compounds were initially investigated for their involvement in browning reactions and in providing a color and bitter taste; however, it was later shown that phenolic compounds protect plants against environmental factors such as low temperatures and free oxygen radicals [ 6 ]. More than 8000 different compounds are collectively referred to as phenolic compounds, making them the most significant class of phytochemicals [ 7 , 8 ], and the most prevalent in the plant kingdom [ 9 ]. Shahidi and Zhong [ 10 ] reported that phenolic compounds are ideal dietary antioxidants.…”

Extraction, Characterization, and Bioactivity of Phenolic Compounds—A Case on Hibiscus Genera

“…Among these substances, phenolic compounds, considered the largest group of plant secondary metabolites, are presented as some of the most interesting bioactive compounds. These molecules have been studied for their extensive bioactive properties, such as antioxidant [5,6], antimicrobial [7,8], anti-inflammatory [9][10][11], and antihypertensive [12,13] effects, among others, which have a great potential for the pharmaceutical, cosmetic, and food industries.…”