Antimicrobial Activity Against Hospital‐related Pathogens of Dual Layer CuO/TiO₂ Coatings Prepared by CVD

Abstract

Photocatalytically active films of TiO 2 /CuO grown by atmospheric pressure thermal (APT)CVD are investigated for activity against multiple antibiotic-resistant pathogens namely, Acinetobacter baumannii, Escherichia coli, Klebsiella pneumoniae, vancomycin-resistant enterococci (VRE), and a recent isolate of methicillin-resistant Staphylococcus aureus (MRSA), that have been shown to persist in the hospital environment. The bacteria are killed by UVA irradiation of the photocatalyst with a >5 log kill within 4-6 h except for the MRSA where a 2-3 log kill is obtained after 6 h increasing to >5 log after 24 h. There is antimicrobial activity in the dark which is enhanced by irradiation with fluorescent light. There is also activity at 5 8C under UVA, but activity is lower when fluorescent light is used for illumination.

Antimicrobial activity of novel nanostructured Cu-SiO2 coatings prepared by chemical vapour deposition against hospital related pathogens

“…ESBL E. coli was more resistant than the standard test strain but was still effectively killed within 24 h. The MRSA strains were much more resistant than the Gram-negative bacteria and were also more resistant than the standard test strain of S. aureus or even than a type strain of MRSA used for testing methicillin resistance. A similar result was obtained for MRSA with titanium dioxide-copper coatings (Foster et al ., 2012) and may reflect increased resistance of MRSA to killing by copper. It should be noted that the numbers or organisms used in the BS ISO method are much higher than have been reported in environmental contamination during outbreaks of MRSA (2.5 × 10 5 vs 500 cfu cm -2 ; Otter et al ., 2011) although in the latter case the organisms may not have been evenly distributed.…”

Nano-based antiviral coatings to combat viral infections

“…In an investigation by Foster et al. chemical vapor deposition (CVD) was used to put CuO/TiO 2 dual-layer nanocoating on a glass surface to check the antimicrobial activity of the coated surface [94] . Several nanomaterial coating strategies have been developed so as to incorporate antimicrobial properties into stainless steel since it is frequently used in making medical tools, hospital surfaces, household as well as commercial establishments [95] , [96] , [97] .…”

Photoactive TiO2 antibacterial coating on surgical external fixation pins for clinical application

“…36,[52][53][54][55] • The high initial bacterial concentration (4×10 8 CFU/mL) may decrease the catalytic effect 56,57 because agglomeration of numerous bacterial cells with TiO 2 particles takes place.…”