Antimicrobial activity and antioxidant potential of the methanolic leaf extracts of three cultivars of date palm trees (Phoenix dactylifera) from Saudi Arabia

Abdallah, Emad M.; Musa, Khalid Hamid; Qureshi, Kamal; Sadeek, Alaa

doi:10.5455/medscience.2017.06.8621

Cited by 8 publications

(6 citation statements)

References 8 publications

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“…The role of the leaves of the Sukari date palm was previously indicated in the fight against bacteria and microbes, against Gram-positive bacterial strains (Staphylococcus aureus Staphylococcus epidermidis, Enterococcus faecalis) and Gram-negative bacterial strains (Klebsiella pneumoniae and Escherichia coli) (Abdallah et al, 2017). These results agree with another study in which the antibacterial activity of acetone, methanol, and water extracts from leaves and pits of Ruthana, Sukkari and Barhi dates was evaluated, based on MIC measurement.…”

Section: Anti-bacterial Activitysupporting

confidence: 88%

The health values of Phoenix dactylifera (dates): A review

et al. 2023

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Dates are one of the most prominent types of fruits spread in the Middle East and North Africa and have been an essential part of thediet of the Arab world since ancient times. It has been called “nature’s candy” due to its sweet taste, which is attributed to its high sugarcontent. Date fruits have great nutritional and therapeutic value, due to the variety of elements they contain, as they contain a goodpercentage of fiber, vitamins, and minerals, especially magnesium, potassium, selenium, calcium salts, and fatty acids (lauric, linoleic,palmitic, and citric acid) as well as an excellent source of antioxidants (flavonoids, polyphenols, and carotenoids) which offer significanthealth-promoting and disease-fighting benefits. In this review, the origin of the date palm fruits was studied, and the nutritional valuewas compared between three types of dates (Ruthana, Sukari, Ajwa) in terms of the nutritional components and the therapeutic values,which is proven by several studies. The nutritional content of date fruits; sugars, beneficial fats, nutritious proteins, and phytochemicalswas reviewed. The health benefits of date fruits include their ability to inhibit free radicals, anti-inflammatory activity, cytotoxicity oncancer cell lines, and the applications for its use as a functional food were indicated. The exact mechanisms still need further researchand exploration, specifically, Ruthana fruits as this type of available literature showed a research gap that could be investigated

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Section: Anti-bacterial Activitysupporting

confidence: 88%

The health values of Phoenix dactylifera (dates): A review

et al. 2023

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“…The leaves of date palm have been shown to exhibit antimicrobial activity against both Gram-positive and Gram-negative bacteria. A study was conducted to test the antimicrobial activity of three different cultivars of date palm leaves, Sukkaria, Hillaliah, and Hoshana, against Gram-positive bacterial strains (Staphylococcus aureus ATCC 25923, Staphylococcus epidermidis ATCC 12228, Enterococcus faecalis ATCC 29212, and Bacillus cereus ATCC 10876) and Gram-negative bacterial strains (Klebsiella pneumoniae ATCC 700603 and Escherichia coli ATCC 35218) [83]. All three methanol leaf extracts exhibited a varied degree of antibacterial properties.…”

Section: Antimicrobial Activitymentioning

confidence: 99%

Middle Eastern Plant Extracts: An Alternative to Modern Medicine Problems

et al. 2020

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Middle Eastern countries are primarily known for their dry sand deserts; however, they have a wider physiographic range which includes upland plateau and mountain ranges. The Middle East is home to various types of plants, such as Phoenix dactylifera (date palm tree), Scrophularia striata (herbaceous plants), and Opuntia ficus-indica (cactus). These plants have been found to have various types of bioactivities, such as antimicrobial activities against both bacteria and fungi, in addition to exhibiting anti-inflammatory effects and anti-cancer characteristics which can be utilized in the clinical setting for treatment. Due to limited reviews focusing on plant extracts from the Middle East, we aim to provide a discourse on plants from this region which have various bioactivities and to provide information on the compounds that can be identified from these plants. This is to enhance our understanding to improve modern medicine problems such as antimicrobial resistance and to find an alternative cure for cancer. It is hoped that the collation of information from this review will enable an assessment of the direct role of Middle Eastern plants in providing therapeutic options to address the predicaments in the medical field.

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“…Plants produce a range of secondary metabolites to combat various pathogens in their surroundings [ 8 , 9 , 10 , 11 , 12 , 13 ]. For example, Nigella sativa (N. sativa) is an invaluable plant that grows naturally in southern Europe, northern Africa, and southern Asia.…”

Section: Introductionmentioning

confidence: 99%

Antiprotozoal Activity of Thymoquinone (2-Isopropyl-5-methyl-1,4-benzoquinone) for the Treatment of Leishmania major-Induced Leishmaniasis: In Silico and In Vitro Studies

et al. 2022

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Leishmaniasis, a neglected tropical parasitic disease (NTPD), is caused by various Leishmania species. It transmits through the bites of the sandfly. The parasite is evolving resistance to commonly prescribed antileishmanial drugs; thus, there is an urgent need to discover novel antileishmanial drugs to combat drug-resistant leishmaniasis. Thymoquinone (2-isopropyl-5-methyl-1,4-benzoquinone; TQ), a primary pharmacologically active ingredient of Nigella sativa (black seed) essential oil, has been reported to possess significant antiparasitic activity. Therefore, the present study was designed to investigate the in vitro and in silico antileishmanial activity of TQ against various infectious stages of Leishmania major (L. major), i.e., promastigotes and amastigotes, and its cytotoxicity against mice macrophages. In silico molecular dockings of TQ were also performed with multiple selected target proteins of L. major, and the most preferred antileishmanial drug target protein was subjected to in silico molecular dynamics (MD) simulation. The in vitro antileishmanial activity of TQ revealed that the half-maximal effective concentration (EC50), half-maximal cytotoxic concentration (CC50), and selectivity index (SI) values for promastigotes are 2.62 ± 0.12 μM, 29.54 ± 0.07 μM, and 11.27, while for the amastigotes, they are 17.52 ± 0.15 μM, 29.54 ± 0.07 μM, and 1.69, respectively. The molecular docking studies revealed that squalene monooxygenase is the most preferred antileishmanial drug target protein for TQ, whereas triosephosphate isomerase is the least preferred. The MD simulation revealed that TQ remained stable in the binding pocket throughout the simulation. Additionally, the binding energy calculations using Molecular Mechanics Generalized-Born Surface Area (MMGBSA) indicated that TQ is a moderate binder. Thus, the current study shows that TQ is a promising antileishmanial drug candidate that could be used to treat existing drug-resistant leishmaniasis.

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Antimicrobial activity and antioxidant potential of the methanolic leaf extracts of three cultivars of date palm trees (Phoenix dactylifera) from Saudi Arabia

Cited by 8 publications

References 8 publications

The health values of Phoenix dactylifera (dates): A review

The health values of Phoenix dactylifera (dates): A review

Middle Eastern Plant Extracts: An Alternative to Modern Medicine Problems

Antiprotozoal Activity of Thymoquinone (2-Isopropyl-5-methyl-1,4-benzoquinone) for the Treatment of Leishmania major-Induced Leishmaniasis: In Silico and In Vitro Studies

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