Antimicrobial activity and phytochemical analysis of crude extracts and essential oils from medicinal plants

Silva, N.C.C.; Barbosa, Luciano; Seito, Leonardo Noboru; Fernandes, Ana Angélica Henrique

doi:10.1080/14786419.2011.564582

Cited by 66 publications

(43 citation statements)

References 10 publications

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“…Previous phytochemical investigation of V. polyanthes resulted in the isolation of a variety of secondary metabolites, which mainly include flavonoids, saponins, triterpenes and sesquiterpene lactones (SLs) (Bohlmann et al, 1981(Bohlmann et al, , 1983Silva et al, 2012).…”

Section: Previous Workmentioning

confidence: 99%

Sesquiterpene lactones, chlorogenic acids and flavonoids from leaves of Vernonia polyanthes Less (Asteraceae)

Igual

Martucci

Costa

et al. 2013

Biochemical Systematics and Ecology

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Section: Previous Workmentioning

confidence: 99%

Sesquiterpene lactones, chlorogenic acids and flavonoids from leaves of Vernonia polyanthes Less (Asteraceae)

Igual

Martucci

Costa

et al. 2013

Biochemical Systematics and Ecology

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“…Focusing on the pharmacological investigations, this species has shown antiulcer [19], antinociceptive, anti-inflammatory [17], antihypertensive [20], antibacterial [21] and antifungal [22] activities. These properties can be related to the presence of compounds such as 3,7-dimethoxy-5,3′,4′-trihydroxyflavone, 3′,4′-dimethoxyluteolin, 3,5-di- O -( E )-caffeoylquinic acid, 4,5-di- O -( E )-caffeoylquinic acid, luteolin, quercetin, protocatechuic acid, quercetin-3- O -β-glucoside, apigenin, isorhamnetin, chrysoeriol-7- O -glycuronyl, and acacetin-7- O -glycuronyl; as well as sesquiterpenes lactones glaucolide A, piptocarphin A, and piptocarphin B, identified in V. polyanthes leaves [18,23].…”

Section: Introductionmentioning

confidence: 99%

Evidence of Bioactive Compounds from Vernonia polyanthes Leaves with Topical Anti-Inflammatory Potential

Rodrigues

Chibli

Santos

et al. 2016

IJMS

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Vernonia polyanthes Less. (Asteraceae), popularly known as “assa-peixe”, is a plant species used in Brazilian traditional medicine for the treatment of cutaneous damage, cicatrization, inflammation, and rheumatism. Based on these ethnopharmacological findings, the current study evaluated the topical anti-inflammatory effects of the hexane (HEVP) and ethyl acetate (EAEVP) extracts from V. polyanthes leaves in experimental models of skin inflammation. Chemical characterization was carried out by HPLC–UV/DAD analysis. Anti-inflammatory activity was evaluated using Croton oil-, arachidonic acid (AA)-, phenol-, ethyl phenylpropiolate (EPP)-, and capsaicin-induced ear edema models in mice. Histopathological evaluation and measurements of myeloperoxidase (MPO) and N-acetyl-β-d-glucosaminidase (NAG) enzymes were also performed. Rutin, luteolin, and apigenin were identified in EAEVP. Topically applied HEVP and EAEVP significantly (p < 0.05, p < 0.01 or p < 0.001) reduced edema induced by five different irritants at the doses tested (0.1, 0.5 and 1.0 mg/ear). Histopathological analysis revealed a reduction of edema, inflammatory cell infiltration, and vasodilation. In addition, the enzymes activity (MPO and NAG) in the ear tissues was reduced by the topical treatment of HEVP and EAEVP (p < 0.05, p < 0.01 or p < 0.001). The results suggest that V. polyanthes leaves are effective against cutaneous damage, which support its traditional use and open up new possibilities for the treatment of skin disorders.

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“…The phytochemical screening of this plant revealed that it is rich in cytoprotective active molecules such as phenolic compounds (McKay and Blumberg 2006). Therefore, owing mainly to their antioxidant (Hernández-Ceruelos et al 2010) and anti-inflammatory (Bulgari et al 2012) properties, chamomile extract, or its essential oils are known to exhibit neuro-protective (Ranpariya et al 2011), anti-allergic (Chan-drashekhar et al 2011, anti-microbial (Silva et al 2012) and anticancer (Matić et al 2013) activities.…”

Section: Introductionmentioning

confidence: 99%

Chemical composition, antioxidant properties and hepatoprotective effects of chamomile (Matricaria recutita L.) decoction extract against alcohol-induced oxidative stress in rat

Sebaï¹,

Jabri²,

Souli³

et al. 2015

gpb

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Abstract. The present study assessed the chemical composition, antioxidant properties, and hepatoprotective effects of subacute pre-treatment with chamomile (Matricaria recutita L.) decoction extract (CDE) against ethanol (EtOH)-induced oxidative stress in rats. The colorimetric analysis demonstrated that the CDE is rich in total polyphenols, total flavonoids and condensed tannins, and exhibited an important in vitro antioxidant activity. The use of LC/MS technique allowed us to identify 10 phenolic compounds in CDE. We found that CDE pretreatment, in vivo, protected against EtOH-induced liver injury evident by plasma transaminases activity and preservation of the hepatic tissue structure. The CDE counteracted EtOH-induced liver lipoperoxidation, preserved thiol -SH groups and prevented the depletion of antioxidant enzyme activity of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx). We also showed that acute alcohol administration increased tissue and plasma hydrogen peroxide (H 2 O 2 ), calcium and free iron levels. More importantly, CDE pre-treatment reversed all EtOH-induced disturbances in intracellular mediators. In conclusion, our data suggest that CDE exerted a potential hepatoprotective effect against EtOH-induced oxidative stress in rat, at least in part, by negatively regulating Fenton reaction components such as H 2 O 2 and free iron, which are known to lead to cytotoxicity mediated by intracellular calcium deregulation.

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Antimicrobial activity and phytochemical analysis of crude extracts and essential oils from medicinal plants

Cited by 66 publications

References 10 publications

Sesquiterpene lactones, chlorogenic acids and flavonoids from leaves of Vernonia polyanthes Less (Asteraceae)

Sesquiterpene lactones, chlorogenic acids and flavonoids from leaves of Vernonia polyanthes Less (Asteraceae)

Evidence of Bioactive Compounds from Vernonia polyanthes Leaves with Topical Anti-Inflammatory Potential

Chemical composition, antioxidant properties and hepatoprotective effects of chamomile (Matricaria recutita L.) decoction extract against alcohol-induced oxidative stress in rat

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