Antimicrobial Activity and Resistance Selection of Different Bioglass S53P4 Formulations Against Multidrug Resistant Strains

Drago, Lorenzo; Vecchi, Elena De; Bortolin, Monica; Toscano, Marco; Mattina, Roberto; Romanò, Carlo Luca

doi:10.2217/fmb.15.57

Cited by 65 publications

(53 citation statements)

References 18 publications

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“…Several studies have shown that BG is angiogenic, 16 osteoconductive, 17,18 and osteoinductive. 19 BG also supports osteoblasts, which are vital for adhesion, growth, differentiation, and new bone formation in bone tissue engineering.…”

Section: 15mentioning

confidence: 99%

Polyurethane/58S bioglass nanofibers: synthesis, characterization, and in vitro evaluation

et al. 2016

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In this study, polyurethane nanofibers containing 5 and 10 wt% synthesized 58S bioglass were designed and fabricated by the electrospinning process. The physicochemical and mechanical properties and in vitro behavior of the scaffolds were evaluated by scanning electron microscopy (SEM), dynamic mechanical thermal analysis (DMTA), Fourier transform infrared spectroscopy (FTIR), contact angle, phosphatebuffered saline (PBS) uptake, in vitro bioactivity, MTT assay, and cellular response. The FTIR results showed an increase in the urethane bond between the OH (from BG) and NCO (from PU) groups with the increase in BG. When the BG amount increased from 5% to 10%, the contact angle decreased to approximately 20 and the PBS uptake of the scaffold increased because of the hydrophilic property of the BG particles. DMTA showed that the glass transition temperature started to shift slightly to higher temperatures from À17 C to À15 C. SEM and X-ray diffraction analysis depicted hydroxyapatite formation on the scaffolds upon immersion in SBF. Cell proliferation and viability also increased significantly with the increase in BG. It is concluded that this composition provides a novel alternative for bone tissue engineering.

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Section: 15mentioning

confidence: 99%

Polyurethane/58S bioglass nanofibers: synthesis, characterization, and in vitro evaluation

et al. 2016

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“…In addition to its osteoconductive and osteostimulative properties, BAG S53P4 has also shown excellent antibacterial properties on both aerobic and anaerobic species invitro [16][17][18][19][20][21][22]. BAG S53P4 is also the first known biomaterial that has been shown to decrease biofilm burden, is effective towards multi-resistant "super bugs" and does not induce resistance in bacteria [23][24][25]. The antibacterial properties of the glass are related to a high pH and an osmotic pressure in the vicinity of the glass, caused by the dissolution process at the glass surface [26].…”

Section: Introductionmentioning

confidence: 99%

Influence of bioactive glass S53P4 granules and putty on osteomyelitis associated bacteria in vitro

Stoor¹,

Frantzén²

2017

Biomedical Glasses

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Bacterial infection of bone tissue and bone marrow, referred to as osteomyelitis, is a challenging clinical problem. In this study we analysed the influence of the granule size of the bone substitute bioactive glass (BAG) S53P4 and the novel putty material containing BAG S53P4 on four clinically important bacteria associated with osteomyelitis; Staphylococcus aureus, methicillin resistant Staphylococuus aureus, Staphylococcus epidermidis and Pseudomonas aeruginosa. Reference materials were the frequently used biomaterial in surgical bone grafting procedures; tricalcium phosphate and an inert glass. Powder of BAG S53P4 was used as a positive control. The materials were incubated with bacterial suspension and the viability of the microbes was determined as colony forming units after cultivation on agar plates. All pathogens lost their viability in contact with the BAG S53P4 granules and the powder of the BAG S53P4. The reference materials tricalcium phosphate and the inert glass had no effect on the viability of the bacteria. The BAG S53P4 putty containing 0.5-0.8 mm granules did not show any antibacterial effect on any of the tested bacteria. New putty compositions need to be investigated to obtain antibacterial properties for this novel bone regeneration biomaterial.

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“…The bioactive glass S53P4 (BG) is a bone‐substitute, silica‐based biomaterial composed of a mixture of oxides (53% SiO 2 , 23% Na 2 O, 20% CaO and 4% P 2 O 5 ). It is osteoconductive and osteoproductive and has the unique property of being antibacterial to many aerobic, anaerobic and multiresistant bacteria . The inhibition of bacterial growth is probably due to the release of ions at the first stage of implantation that causes elevation of pH and osmotic pressure.…”

mentioning

confidence: 99%

Anatomical, functional and quality‐of‐life results for mastoid and epitympanic obliteration with bioactive glass s53p4: a prospective clinical study

Bernardeschi

Pyatigorskaya

Russo

et al. 2016

Clinical Otolaryngology

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Antimicrobial Activity and Resistance Selection of Different Bioglass S53P4 Formulations Against Multidrug Resistant Strains

Abstract: BAG-S53P4 has a significant potential as bone substitute for the treatment of infections caused by multiresistant microorganisms.

Cited by 65 publications

References 18 publications

Polyurethane/58S bioglass nanofibers: synthesis, characterization, and in vitro evaluation

Polyurethane/58S bioglass nanofibers: synthesis, characterization, and in vitro evaluation

Influence of bioactive glass S53P4 granules and putty on osteomyelitis associated bacteria in vitro

Anatomical, functional and quality‐of‐life results for mastoid and epitympanic obliteration with bioactive glass s53p4: a prospective clinical study

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