Antimicrobial activity and toxicity of extracts from the bark and leaves of South African indigenous Meliaceae against selected pathogens

Oyedeji-Amusa, M.O.; Vuuren, Sandy van; Wyk, B.-E. Van

doi:10.1016/j.sajb.2020.06.032

Cited by 12 publications

(11 citation statements)

References 39 publications

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“…The synthesized compounds ( CA1–CA10 ) were evaluated for their antimicrobial activity against Gram-positive bacteria ( Staphylococcus aureus (sa), Enterococcus faecalis (ef), Staphylococcus agalactiae (sg), Micrococcus luteus (ml), and Bacillus agri (ba)) and Gram-negative bacteria ( Escherichia coli (ec), Salmonella typhi (st), Pseudomonas aeruginosa (pa), Klebsiella pneumoniae (kp), and Acinetobacter baumannii (ab)) using the broth microdilution method (supplementary information) [ 33 ]. The results are summarized in Table 1 .…”

Section: Resultsmentioning

confidence: 99%

Comparative investigation of derivatives of (E)-N-((E)-3-phenylallylidene)aniline: Synthesis, structural characterization, biological evaluation, density functional theory analysis, and in silico molecular docking

Waziri,

Kelani,

Oyedeji-Amusa

et al. 2024

Heliyon

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Section: Resultsmentioning

confidence: 99%

Comparative investigation of derivatives of (E)-N-((E)-3-phenylallylidene)aniline: Synthesis, structural characterization, biological evaluation, density functional theory analysis, and in silico molecular docking

Waziri,

Kelani,

Oyedeji-Amusa

et al. 2024

Heliyon

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“…These studies were conducted over a span of years, ranging from 2006 to 2021. Specifically, three of them were carried out between 2000 and 2010 [ 25 , 27 , 28 ], eight studies were conducted between 2011 and 2020 [ 17 – 20 , 22 – 24 , 26 ], and one study was conducted in 2021 [ 21 ].…”

Section: Resultsmentioning

confidence: 99%

A scoping review on the use of traditional medicine and oral health in Africa

Foláyan,

Olagunju,

Abodunrin

et al. 2024

PLoS ONE

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Background This review aimed to chart the landscape of literature concerning the precise applications of traditional medicine in managing specific oral diseases and, in doing so, to pinpoint knowledge gaps surrounding the use of traditional medicine for oral disease management in the African context. Methods A systematic search of the literature was conducted on PubMed, Web of Science, Scopus, and CINAHL. The search was conducted from the inception of the database till September 2023. A search of related citations and references was also carried out. Only English language publications were included. A summary of studies that met the inclusion criteria was conducted. Results Of the 584 records identified, 11 were duplicates and 12 studies, published between 2006 and 2021, met the inclusion criteria. The studies were published from eight countries located in the five sub-regions on the continent. All the studies were either experimental designs or ethnobotanical surveys and they all utilized plant-based remedies. The five experimental studies aimed to assess the impact of whole plants or plant extracts on the three microorganisms responsible for dental caries and seven responsible for periodontal diseases. The number of plant species identified by the seven ethnobotanical surveys ranged from 29 to 62 while the number of plan families ranged from 15 to 29. The remedies were either topical applied, use as mouth rinses, gargled, or chewed. The systemic routes of administration identified were inhalation and drinking. The remedies were used for the treatment of hard such as dental caries and tooth sensitivity, to soft tissue lesions such as mouth ulcers, gingival bleeding, and mouth thrush. Other oral disorders managed include halitosis, jaw fracture, and oral cancer. Conclusions Given the increasing prevalence of oral diseases within the region, the shortage of oral healthcare professionals and limited access to financial resources, it becomes imperative to support the generation of empirical evidence to enhance the provision of traditional medicine for oral healthcare in Africa.

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“…Indeed, several studies reported toxic, carcinogenic, and mutagenic effects for extracts prepared from plants traditionally used as medicines [33]. Several of the studies highlighted in this review have also investigated the toxicity of southern African plant species traditionally used to treat UTIs [40,41,71,73,77,80]. Whilst most of those studies reported that the plant extracts were nontoxic, one study reported very low LC 50 values against Vero cells for several plant species, indicating that those species may not be safe to use medicinally.…”

Section: Discussionmentioning

confidence: 99%

A Review of Plant-Based Therapies for the Treatment of Urinary Tract Infections in Traditional Southern African Medicine

Cock

Mavuso

Vuuren

2021

Evidence-Based Complementary and Alternative Medicine

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Urinary tract infections (UTIs) are amongst the most common bacterial infections globally, with ∼11% of the world’s population contracting at least one infection annually. Several South African plants are used in traditional healing systems to treat UTIs, yet the therapeutic potential of these plants against bacteria that cause UTI remains poorly explored. This study documents southern African plant species used traditionally to treat UTIs. An extensive literature review was undertaken to document the southern African plant species that are used in traditional South African medicine to treat UTIs, thereby highlighting gaps in the current research that require further study. One hundred and fifty-three southern African plant species that are used to treat UTIs were identified. Eighty-five southern African plants were identified as having noteworthy inhibitory activity against the major UTI-causing bacteria. Few of those studies screened against all of the bacterial causes of UTIs, and none of those studies examined the mechanism of action of the plant preparations. Furthermore, many of those studies did not test the toxicity of the plant extracts, so an evaluation of the safety for therapeutic usage was lacking. Substantial further research is to determine their potential for therapeutic use.

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Antimicrobial activity and toxicity of extracts from the bark and leaves of South African indigenous Meliaceae against selected pathogens

Cited by 12 publications

References 39 publications

Comparative investigation of derivatives of (E)-N-((E)-3-phenylallylidene)aniline: Synthesis, structural characterization, biological evaluation, density functional theory analysis, and in silico molecular docking

Comparative investigation of derivatives of (E)-N-((E)-3-phenylallylidene)aniline: Synthesis, structural characterization, biological evaluation, density functional theory analysis, and in silico molecular docking

A scoping review on the use of traditional medicine and oral health in Africa

A Review of Plant-Based Therapies for the Treatment of Urinary Tract Infections in Traditional Southern African Medicine

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