Antimicrobial activity and toxicity of Syzygium australe and Syzygium leuhmannii fruit extracts

Sautron, Cyril; Cock, Ian Edwin

doi:10.5530/pc.2014.1.8

Cited by 59 publications

(60 citation statements)

References 27 publications

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“…This is in contrast to previous studies which have reported a greater susceptibility of Gram-positive bacteria towards solvent extracts for South American, [45] African, [46] and Australian [47] plant extracts. Results within this laboratory [43,[48][49][50] have also confirmed the greater susceptibility of Gram-positive bacteria towards other plant extracts, although other examples of plants having a greater effect on Gram negative bacteria have also been reported. [27][28][29]51,52] The K. africana fruit extracts were particularly potent inhibitors of P. mirabilis.…”

Section: Discussionmentioning

confidence: 67%

An examination of the antibacterial, antifungal, anti-Giardial and anticancer properties of Kigelia africana fruit extracts

Arkhipov¹,

Sirdaarta²,

Rayan³

et al. 2014

Phcog Commn.

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Section: Discussionmentioning

confidence: 67%

An examination of the antibacterial, antifungal, anti-Giardial and anticancer properties of Kigelia africana fruit extracts

Arkhipov¹,

Sirdaarta²,

Rayan³

et al. 2014

Phcog Commn.

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“…The fruit 19 and leaves [28][29][30] 31 It is therefore perhaps not surprising that the Syzygium spp. extracts screened in our study displayed growth inhibitory activity towards B. anthracis.…”

Section: Discussionmentioning

confidence: 99%

“…Recent studies have demonstrated the potent inhibitory activity of several Australian plants with high antioxidant capacities against a wide panel of medicinally important bacteria. [18][19][20][21] Furthermore, potent growth inhibition of the bacterial triggers of autoimmune inflammatory diseases has also been reported for high antioxidant Australian fruits [22][23][24] and culinary herbs.…”

Section: Introductionmentioning

confidence: 99%

Growth inhibition of the zoonotic bacteria Bacillus anthracis by high antioxidant Australian plants: New leads for the prevention and treatment of anthrax

Wright¹,

Matthews²,

Greene³

et al. 2015

Phcog Commn.

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Introduction: Anthrax is severe acute disease caused by Bacillus anthracis infections. If untreated, it often results in mortality. High antioxidant plant extracts have documented therapeutic properties as general antiseptics, inhibiting the growth of a wide variety of bacterial species. This study examines the ability of selected high antioxidant Australian plant extracts to inhibit B. anthracis growth. Methods: Solvent extracts were prepared using various high antioxidant Australian fruits and herbs and investigated by disc diffusion assay for the ability to inhibit the growth of an environmental strain of B. anthracis. Their MIC values were determined to quantify and compare their efficacies. Toxicity was determined using the Artemia franciscana nauplii bioassay. The most potent extracts were analysed by non-targeted HPLC-QTOF mass spectroscopy (with screening against 3 compound databases) for the identification and characterisation of individual components in crude plant extracts. Results: Methanolic and aqueous extracts of several high antioxidant plant extract sdisplayed potent antibacterial activity in the disc diffusion assay against B. anthracis. The aqueous and methanolic extracts of lemon aspen, as well as the methanolic extracts of muntries, Illawarra plum and native tamarind were particularly potent growth inhibitors with MIC values<1000 µg/mL. Furthermore, all of these extracts were nontoxic in the Artemia fransiscana bioassay, with LC50 values substantially>1000 µg/mL. Non-biased phytochemical analysis of the lemon aspen aqueous and methanolic extracts putatively identified 85 compounds and highlighted several that may contribute to the ability of these extracts to inhibit the growth of B. anthracis. Conclusion: The low toxicity of several high antioxidant plant extracts and their potent inhibitory bioactivity against B. anthracis indicates their potential as medicinal agents in the treatment and prevention of anthrax. Lemon aspen is particularly worthy of further study.

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“…29,30 Briefly, the extracts were diluted in deionised water and tested across a range of concentrations. Discs were impregnated with 10 µL of the test dilutions, allowed to dry and placed onto inoculated plates.…”

Section: Minimum Inhibitory Concentration (Mic) Determinationmentioning

confidence: 99%

GC-MS Analysis of Commiphora molmol Oleo-Resin Extracts which Inhibit the growth of Bacterial Triggers of Selected Autoimmune Diseases

Biggs¹,

Sirdaarta²,

White³

et al. 2016

Phcogj

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Introduction: Myrrh has been used traditionally for the inhibition of microbial growth and for the treatment of rheumatic diseases. Despite this, myrrh extracts are yet to be tested for the ability to inhibit the growth of the bacterial triggers of autoimmune inflammatory diseases. Methods: Solvent extracts prepared from commercially obtained myrrh resin were analysed for the ability to inhibit the growth of bacterial species associated with initiating rheumatoid arthritis (P. mirabilis), ankylosing spondylitis (K. pneumoniae) and multiple sclerosis (A. baylyi, P. aeruginosa) by disc diffusion assay, and quantified by MIC determination. Toxicity was determined by Artemia franciscana bioassay. The most potent inhibitory extract was investigated using non-targeted GC-MS head space analysis (with screening against a compound database) for the identification and characterisation of individual components in the crude plant extracts. Results: Methanolic myrrh extract inhibited the growth of all bacterial species tested. The growth inhibition of this extract was particularly notable against P. mirabilis and K. pneumoniae, with MIC values substantially < 1000 µg/mL for both reference and clinical bacterial strains. Indeed, the MIC values of the methanolic extract against P. mirabilis reference and clinical strains were 572 and 463 µg/mL respectively. The methanolic extract also inhibited the growth of A. baylyi (MIC approximately 3000 µg/mL) and P. aeruginosa (MIC approximately 1800 µg/mL). However, the MICs against these bacteria was indicative of only moderate inhibitory activity. The aqueous, ethyl acetate,

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Antimicrobial activity and toxicity of Syzygium australe and Syzygium leuhmannii fruit extracts

Cited by 59 publications

References 27 publications

An examination of the antibacterial, antifungal, anti-Giardial and anticancer properties of Kigelia africana fruit extracts

An examination of the antibacterial, antifungal, anti-Giardial and anticancer properties of Kigelia africana fruit extracts

Growth inhibition of the zoonotic bacteria Bacillus anthracis by high antioxidant Australian plants: New leads for the prevention and treatment of anthrax

GC-MS Analysis of Commiphora molmol Oleo-Resin Extracts which Inhibit the growth of Bacterial Triggers of Selected Autoimmune Diseases

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