Antimicrobial Activity of a Compound Isolated from an Oil-Macerated Garlic Extract

Yoshida, Hisae; Iwata, Nami; Katsuzaki, Hirotaka; Naganawa, Rie; Ishikawa, Kinya; Fukuda, Hiroyuki; Fujino, Takeshi; Suzuki, Atsushi

doi:10.1271/bbb.62.1014

Cited by 74 publications

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“…There are numerous reports indicating the efficacy of garlic in the prevention and treatment of a variety of diseases and for validating its traditional uses. For instance, garlic has been described to exhibit broad antimicrobial activity against bacteria ,fungi and virus [25], [26], [27], antitumor activity [28], as well as antithrombotic, antiarthritic, hypolipidemic, and hypoglycemic activities [30,31] Moreover, garlic has been reported to be effective against diverse parasites such as Amoeba [32], Leishmania [33], Trypanosoma [34] and Cryptosporidium [35]. The efficacy of garlic on Coccidia infections has been reported in rabbits [36].…”

Section: Introductionmentioning

confidence: 99%

Efficacy of turmeric (Curcuma longa) and garlic (Allium sativum) on Eimeria species in broilers

Elkhtam¹,

Shata

El-Hewaity³

2014

International Journal of Basic and Applied Sciences

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In this study, powders were evaluated for their anticoccidial effects. In in vitro, sporulated oocysts of mixed Eimeria species isolated from naturally infected chickens were randomly assigned to 10, 5, 2.5, 1.25, 0.6, 0.3, 0.2 and 0.08 g turmeric and garlic powders /liter distilled water (g/L). The efficacy of garlic was higher (up to 80%) than turmeric (up to 66.6%) at different concentrations. In the in vivo study, one-day old chicks were divided into 7 equal groups. All groups were infected with 10.000 viable sporulated oocysts of mixed Eimeria spp. orally except G7 (-ve control). G1 and G2 were infected and supplemented with turmeric powder at 10 and 5 g/L, respectively, G3 and G4 were infected and supplemented with garlic powder at 10 and 5 g/L, respectively. G5 was infected and treated with Amprolium at 1.25 g/L, G6 (+ve control) infected, non-treated and G7 was non-infected & non-treated. Clinical signs and lesion score were less sever in garlic supplemented groups compared with turmeric supplemented groups. Reduction of total oocyst count in garlic supplemented group more than turmeric supplemented group. It is concluded that Garlic powder was more effective than turmeric powder in treatment and control of coccidiosis.

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Section: Introductionmentioning

confidence: 99%

Efficacy of turmeric (Curcuma longa) and garlic (Allium sativum) on Eimeria species in broilers

Elkhtam¹,

Shata

El-Hewaity³

2014

International Journal of Basic and Applied Sciences

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“…In addition to ajoene, OMGE primarily contained devinylajoene, vinyldithiin, and some thiosulfinates. [3][4][5] Our results suggest that, other than ajoene, no component of OMGE influenced the increase in intestinal IgA production, and that no additive or synergistic effects were apparent between ajoene and the other components of OMGE.…”

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confidence: 74%

“…4,5) Ajoene was shown by Block et al 6) in 1984 to be an inhibitor of platelet aggregation, and its various biological activities have been well studied. Ajoene has exhibited antibiotic, 7) hepatoprotective, 8) anti-tumor, 9) and anti-diabetic effects.…”

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confidence: 99%

Enhancement of Intestinal IgA Production by Ajoene in Mice

Washiya¹,

Nishikawa²,

Fujino³

2013

Bioscience, Biotechnology, and Biochemistry

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“…18) The isomers of 2, Z-2,6,7-trithiadeca-4,9-diene 2-oxide 19) and E-2,6,7-trithiadeca-4,8-diene 2-oxide 20) were also obtained from the oil-macerated garlic extract. The two-dimensional NMR spectroscopy, heteronuclear multiple-quantum coherence (HMQC), and HMBC, indicated that the structure of 3 can be represented as a sequence of an allyl-a dithiine-a propenyl-a dithiine-an allyl group.…”

Section: )mentioning

confidence: 99%

Acyclic Sulfides, Garlicnins L-1–L-4, E, and F, from <i>Allium sativum</i>

Nohara

Fujiwara

Ikeda

et al. 2014

CHEMICAL & PHARMACEUTICAL BULLETIN

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Six novel acyclic sulfides, named garlicnins L-1-L-4 (1-4), E (5), and F (6), were isolated from the acetone extracts, with the ability to suppress M2 macrophage activation, of the bulbs of garlic (Allium sativum L.), and their chemical structures were characterized. Key words Allium sativum; acyclic sulfide; garlicnin L-1; garlicnin E; garlicnin F; macrophage activationGarlic, Allium sativum L. (Liliaceae) is at the top of the National Cancer Institute's list of designer foods that prevent cancer.1) Various biological activities of garlic are generally classified into two categories: (i) cardiovascular disease prevention and (ii) cancer prevention.2-5) The activities of the former include the inhibition of cholesterol synthesis, platelet aggregation, and arterial smooth muscle cell proliferation as well as anti-inflammatory, antioxidant, and hydrogen sulfidemediated vasodilatory effects. The activities of the latter include the effects on carcinogen metabolism (enhanced cellular glutathione synthesis induced cell cycle arrest and apoptosis) and the prevention of Helicobacter pylori infection, gastric cancer, and colorectal cancer are effects of the latter category. 2-5)The chemistry of garlic sulfides is summarized in a text book edited by Block.4) In a previous work, we isolated a novel, stable sulfide, named as onionin A, 6)5-(1-propenyl)-3,4-dimethyltetrahydrothiophene-2-sulfoxide-S-oxide, from the acetone extract of Allium cepa L. and found that it inhibits macrophage activation. Similarly, the sulfur-containing substances, garlicnins A, from the acetone-soluble extract of A. sativum L. were isolated along with E-azoene 10) and characterized to help in the development of natural, healthy foods that may prevent and combat disease, particularly tumors. Successively, the related acyclic sulfides garlicnins L-1-L-4, E, and F, were isolated and characterized. This paper discusses the characterization of the chemical structure of these compounds.Chinese garlic (1061 g) was roughly chopped and blended in a mixer along with acetone. Subsequently, the mixture was soaked in additional acetone for 3 d at room temperature. The filtrate was evaporated at 40°C in vacuo to obtain a residue (26.1 g), which was then subjected to polystyrene gel column chromatography . It was first eluted with water, then with methanol (the residue after evaporation: 5.90 g), and finally with acetone (the residue after evaporation: 0.32 g). A part of the methanolic eluate (3.0 g) was partitioned between ethyl acetate (EtOAc) and water. The respective residues (Fr.

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Antimicrobial Activity of a Compound Isolated from an Oil-Macerated Garlic Extract

Cited by 74 publications

References 0 publications

Efficacy of turmeric (Curcuma longa) and garlic (Allium sativum) on Eimeria species in broilers

Efficacy of turmeric (Curcuma longa) and garlic (Allium sativum) on Eimeria species in broilers

Enhancement of Intestinal IgA Production by Ajoene in Mice

Acyclic Sulfides, Garlicnins L-1–L-4, E, and F, from <i>Allium sativum</i>

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