Antimicrobial Activity of a Phage Mixture and a Lactic Acid Bacterium against Staphylococcus aureus from Bovine Mastitis

Titze, Isabel; Krömker, Volker

doi:10.3390/vetsci7010031

Cited by 20 publications

(21 citation statements)

References 57 publications

(93 reference statements)

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“…Both in vitro and in vivo studies have shown the effectiveness of bacteriophage-based therapy in the reduction of Staphylococcus aureus bacteria that causes mastitis in cattle [ 97 , 98 ]. However, in the case of pigs, Verstappen et al [ 49 ] showed, in in-vitro and in-vivo assays, no inhibition of nasal colonization by MRSA strains with the use of specific phages.…”

Section: Bacteriophagesmentioning

confidence: 99%

Last Call for Replacement of Antimicrobials in Animal Production: Modern Challenges, Opportunities, and Potential Solutions

Nowakiewicz

Zięba²,

Gnat

et al. 2020

Antibiotics

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The constant market demand for easily available and cheap food of animal origin necessitates an increasing use of antibiotics in animal production. The alarming data provided by organizations monitoring drug resistance in indicator and pathogenic bacteria isolated from humans and animals indicate a possible risk of a return to the preantibiotic era. For this reason, it seems that both preventive and therapeutic measures, taken as an alternative to antimicrobials, seem not only advisable but also necessary. Nevertheless, the results of various studies and market analyses, as well as difficulties in the implementation of alternative substances into veterinary medicine, do not guarantee that the selected alternatives will completely replace antimicrobials in veterinary medicine and animal production on a global scale. This publication is a brief overview of the drug resistance phenomenon and its determinants, the steps taken to solve the problem, including the introduction of alternatives to antimicrobials, and the evaluation of some factors influencing the potential implementation of alternatives in animal production. The review also presents two groups of alternatives, which, given their mechanism of action and spectrum, are most comparable to the effectiveness of antibiotics, as emphasized by the authors.

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Section: Bacteriophagesmentioning

confidence: 99%

Last Call for Replacement of Antimicrobials in Animal Production: Modern Challenges, Opportunities, and Potential Solutions

Nowakiewicz

Zięba²,

Gnat

et al. 2020

Antibiotics

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“…Recently, more studies on phage therapy for mastitis in cattle have been developed with positive, significant results using phage cocktails in mouse models. They have shown a decrease in the number of colony-forming units and a significant improvement in mastitis pathology, even greater than in mice treated with a single phage [ 55 , 73 ].…”

Section: Phage Therapy In the Veterinary Fieldmentioning

confidence: 99%

Phage Therapy in Livestock and Companion Animals

Ferriol-González

Domingo‐Calap

2021

Antibiotics

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The irrational use of antibiotics has led to a high emergence of multi-drug resistant (MDR) bacteria. The traditional overuse of antibiotics in the animal feed industry plays a crucial role in the emergence of these pathogens that pose both economic and health problems. In addition, antibiotics have also recently experienced an increase to treat companion animal infections, promoting the emergence of MDR bacteria in pets, which can reach humans. Phages have been proposed as an alternative for antibiotics for the treatment of livestock and companion animal infections due to their multiple advantages as adaptative drugs, such as their ability to evolve, to multiply at the site of infections, and their high specificity. Moreover, phage-derived enzymes may also be an interesting approach. However, the lack of regulation for this type of pharmaceutical hinders its potential commercialization. In this review, we summarize the main recent studies on phage therapy in livestock and companion animals, providing an insight into current advances in this area and the future of treatments for bacterial infections.

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“…MIC of lacticin A164 and lacticin BH5 needed to inhibit the growth of H. pylori ATCC 43504 was 12.5 mg l À1 . 108…”

Section: Lacticinmentioning

confidence: 99%

Application of bacteriocins in food preservation and infectious disease treatment for humans and livestock: a review

Zarin

Lee

et al. 2020

RSC Adv.

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Antimicrobial Activity of a Phage Mixture and a Lactic Acid Bacterium against Staphylococcus aureus from Bovine Mastitis

Cited by 20 publications

References 57 publications

Last Call for Replacement of Antimicrobials in Animal Production: Modern Challenges, Opportunities, and Potential Solutions

Last Call for Replacement of Antimicrobials in Animal Production: Modern Challenges, Opportunities, and Potential Solutions

Phage Therapy in Livestock and Companion Animals

Application of bacteriocins in food preservation and infectious disease treatment for humans and livestock: a review

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