Antimicrobial activity of berberine—a constituent ofMahonia aquifolium

Cernáková, M; Kostálová, D

doi:10.1007/bf02818693

Cited by 144 publications

(48 citation statements)

References 19 publications

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“…Berberine served as a positive control and demonstrated activity consistent with previous reports (Amin et al, 1969; Čerňáková and Košt’álová, 2002). …”

Section: Figuresupporting

confidence: 84%

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Antimicrobial fungal endophytes from the botanical medicine goldenseal ( Hydrastis canadensis )

Egan

Kaur

Raja

et al. 2016

Phytochemistry Letters

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The potential of fungal endophytes to alter or contribute to plant chemistry and biology has been the topic of a great deal of recent interest. For plants that are used medicinally, it has been proposed that endophytes might play an important role in biological activity. With this study, we sought to identify antimicrobial fungal endophytes from the medicinal plant goldenseal (Hydrastis canadensis L., Ranunculaceae), a plant used in traditional medicine to treat infection. A total of 23 fungal cultures were obtained from surface-sterilized samples of H. canadensis roots, leaves and seeds. Eleven secondary metabolites were isolated from these fungal endophytes, five of which had reported antimicrobial activity. Hydrastis canadensis plant material was then analyzed for the presence of fungal metabolites using liquid chromatography coupled to high resolving power mass spectrometry. The antimicrobial compound alternariol monomethyl ether was detected both as a metabolite of the fungal endophyte Alternaria spp. isolated from H. canadensis seeds, and as a component of an extract from the H. canadensis seed material. Notably, fungi of the Alternaria genus were isolated from three separate accessions of H. canadensis plant material collected in a time period spanning 5 years. The concentration of alternariol monomethyl ether (991 mg/kg in dry seed material) was in a similar range to that previously reported for metabolites of ecologically important fungal endophytes. The seed extracts themselves, however, did not possess antimicrobial activity.

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“…Berberine served as a positive control and demonstrated activity consistent with previous reports (Amin et al, 1969; Čerňáková and Košt’álová, 2002). …”

Section: Figuresupporting

confidence: 84%

“… a MIC is defined as the concentration that caused OD 600 to be reduced by ≥ 95%. b Concentration is expressed as μg/mL of dried plant extract per mL of assay well volume. c Berberine served as a positive control and demonstrated activity consistent with previous reports (Amin et al, 1969; Čerňáková and Košt’álová, 2002). …”

Section: Figuresupporting

confidence: 80%

Antimicrobial fungal endophytes from the botanical medicine goldenseal ( Hydrastis canadensis )

Egan

Kaur

Raja

et al. 2016

Phytochemistry Letters

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“…In addition, BBR has potential pharmacological effects, including effects on metabolic abnormalities, and antiarrhythmic, antihypertensive, anticancer, antidiabetic, and antihyperlipidenmic effects [23,24,25,26]. Accumulated evidence has shown that BBR can reduce lipogenesis in vitro and in vivo through a series of mechanisms, including the downregulation of the expression of peroxisome proliferator activated receptor γ (PPARγ) [27].…”

Section: Introductionmentioning

confidence: 99%

Berberine Alleviates Olanzapine-Induced Adipogenesis via the AMPKα–SREBP Pathway in 3T3-L1 Cells

Zhao

Feng

et al. 2016

IJMS

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The aim of this study was to investigate the mechanisms underlying the inhibitory effects of berberine (BBR) on olanzapine (OLZ)-induced adipogenesis in a well-replicated 3T3-L1 cell model. Oil-Red-O (ORO) staining showed that BBR significantly decreased OLZ-induced adipogenesis. Co-treatment with OLZ and BBR decreased the accumulation of triglyceride (TG) and total cholesterol (TC) by 55.58% ± 3.65% and 49.84% ± 8.31%, respectively, in 3T3-L1 adipocytes accompanied by reduced expression of Sterol regulatory element binding proteins 1 (SREBP1), fatty acid synthase (FAS), peroxisome proliferator activated receptor-γ (PPARγ), SREBP2, low-density lipoprotein receptor (LDLR), and hydroxymethylglutaryl-coenzyme A reductase (HMGR) genes compared with OLZ alone. Consistently, the co-treatment downregulated protein levels of SREBP1, SREBP2, and LDLR by 57.71% ± 9.42%, 73.05% ± 11.82%, and 59.46% ± 9.91%, respectively. In addition, co-treatment reversed the phosphorylation level of AMP-activated protein kinase-α (AMPKα), which was reduced by OLZ, determined via the ratio of pAMPKα:AMPKα (94.1%) compared with OLZ alone. The results showed that BBR may prevent lipid metabolism disorders caused by OLZ by reversing the degree of SREBP pathway upregulated and the phosphorylation of AMPKα downregulated. Collectively, these results indicated that BBR could be used as a potential adjuvant to prevent dyslipidemia and obesity caused by the use of second-generation antipsychotic medication.

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“…Overall, the recent studies indicate that berberine has various pharmacological effects including inhibition of intestinal fluid accumulation and ion secretion [129], anti-inflammatory [130], antimicrobial [131], anti-inhibition of smooth muscle contraction [132], and action on TJs [124] each of which may contribute to the antidiarrhea effect. The therapeutic dosage for most clinical usage is 200 mg orally two to four times daily [133].…”

Section: Berberinementioning

confidence: 99%

Antibacterial and Antidiarrheal Activities of Plant Products against Enterotoxinogenic Escherichia coli

Dubreuil

2013

Toxins

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Enterotoxigenic Escherichia coli (ETEC) produces two types of enterotoxins: heat-labile (LT) and heat-stable (STa and STb). These molecules are involved in the induction of secretory diarrhea in animals including humans. This condition is currently treated using a fluid replacement therapy and antibiotics. This treatment is often not available to people in developing countries, and several die from the condition provoke by ETEC. Over the years, plants and plant extracts have been use as traditional medicine to treat various gastrointestinal ailments including diarrhea. Many of these plant products have been claimed to be active against diarrhea, however few have been extensively studied. The main objective of this review was to gather the scattered information on the antidiarrheal activities reported for various plant products on ETEC. This includes two major effects: (1) The inhibitory effect on bacterial growth or viability and (2) The interference with ETEC enterotoxins activity upon the intestinal epithelium. We will focus on plant products and extracts for which we have major indications of their biological activity against ETEC and their enterotoxins. Because Vibrio cholerae toxin (CT) is structurally, antigenically and mechanistically related to LT, it will also be discussed in this review.

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Antimicrobial activity of berberine—a constituent ofMahonia aquifolium

Cited by 144 publications

References 19 publications

Antimicrobial fungal endophytes from the botanical medicine goldenseal ( Hydrastis canadensis )

Antimicrobial fungal endophytes from the botanical medicine goldenseal ( Hydrastis canadensis )

Berberine Alleviates Olanzapine-Induced Adipogenesis via the AMPKα–SREBP Pathway in 3T3-L1 Cells

Antibacterial and Antidiarrheal Activities of Plant Products against Enterotoxinogenic Escherichia coli

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