Antimicrobial activity of bovine psoriasin

Regenhard, Petra; Leippe, Matthias; Schubert, Sabine; Podschun, Rainer; Kalm, E.; Grötzinger, Joachim; Looft, Christian

doi:10.1016/j.vetmic.2008.12.001

Cited by 34 publications

(35 citation statements)

References 21 publications

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“…Our findings are in agreement with these reports, and further suggest that the impediment in epithelial defenses in SIV infection also manifests in reduced production of psoriasin and other AMPs that presumably regulate the microbiota. It is also worth noting that the bactericidal activity of psoriasin is highly specific to E. coli [56], raising the possibility that the loss of psoriasin may have contributed to the colonization of E. coli on the tongue dorsum of one of the SIV infected macaques (Fig. 4).…”

Section: Discussionmentioning

confidence: 99%

Transcription Profiling Reveals Potential Mechanisms of Dysbiosis in the Oral Microbiome of Rhesus Macaques with Chronic Untreated SIV Infection

Ocon

Murphy²,

Dang

et al. 2013

PLoS ONE

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A majority of individuals infected with human immunodeficiency virus (HIV) have inadequate access to antiretroviral therapy and ultimately develop debilitating oral infections that often correlate with disease progression. Due to the impracticalities of conducting host-microbe systems-based studies in HIV infected patients, we have evaluated the potential of simian immunodeficiency virus (SIV) infected rhesus macaques to serve as a non-human primate model for oral manifestations of HIV disease. We present the first description of the rhesus macaque oral microbiota and show that a mixture of human commensal bacteria and “macaque versions” of human commensals colonize the tongue dorsum and dental plaque. Our findings indicate that SIV infection results in chronic activation of antiviral and inflammatory responses in the tongue mucosa that may collectively lead to repression of epithelial development and impact the microbiome. In addition, we show that dysbiosis of the lingual microbiome in SIV infection is characterized by outgrowth of Gemella morbillorum that may result from impaired macrophage function. Finally, we provide evidence that the increased capacity of opportunistic pathogens (e.g. E. coli) to colonize the microbiome is associated with reduced production of antimicrobial peptides.

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Section: Discussionmentioning

confidence: 99%

Transcription Profiling Reveals Potential Mechanisms of Dysbiosis in the Oral Microbiome of Rhesus Macaques with Chronic Untreated SIV Infection

Ocon

Murphy²,

Dang

et al. 2013

PLoS ONE

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“…) and bovines (Regenhard et al . ). S100A7 was first identified in the epithelial cells of human psoriatic skin (Madsen et al .…”

Section: S100a7 (S100 Calcium Binding Protein A7)mentioning

confidence: 97%

“…These strongly suggests that b-defensin has a crucial role on the local defense system in mammary glands. S100A7 (S100 CALCIUM BINDING PROTEIN A7) S100A7 (psoriasin) is a Ca-binding protein and one of the antimicrobial factors that exhibit antimicrobial activity against E. coli in humans (Glaser et al 2005) and bovines (Regenhard et al 2009). S100A7 was first identified in the epithelial cells of human psoriatic skin (Madsen et al 1991;Al-Haddad et al 1999) and is secreted by breast cancer cells (Enerback et al 2002) and psoriatic keratinocytes (Madsen et al 1991).…”

Section: B-defensinmentioning

confidence: 99%

Control mechanisms for producing antimicrobial factors in ruminant mammary gland

Isobe

2017

Animal Science Journal

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Mastitis, a symptom of inflammation in mammary tissue by infection with various kinds of bacteria, causes huge economic losses in the milk industry. One of the popular methods for treatment of mastitis is antibiotics, although this prohibits milk shipping and sometimes causes resistant microbes. Therefore, a new strategy to treat mastitis without antibiotics is eagerly required around the world. Antimicrobial factors belong to innate immunity and can start their function extremely early after bacterial stimulation. These factors have antimicrobial activity for a broad spectrum of bacteria. Elucidation of causal mechanisms and functions of antimicrobial factors in the mammary gland is thought to result in suitable methods for prevention and treatment of mastitis. Therefore, this review introduces traits of some antimicrobial factors and the mechanisms for expressing, producing and secreting them in the mammary gland. For antimicrobial factors, lingual antimicrobial peptide (LAP), S100A7, cathelicidin and lactoferrin are controlled in different sites and different time courses, suggesting that antimicrobial factors play different roles for local defense against bacterial infection in the mammary gland. These findings will contribute to the development of prevention and treatment methods for mastitis.

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“…Psoriasin (S100A7) is one of the peptides that exhibit antimicrobial activity against E. coli in humans (Glaser et al, 2005) and cattle (Regenhard et al, 2009). However, the mechanism of the antimicrobial action of S100A7 remains unclear (Gallo & Hooper, 2012).…”

Section: Introductionmentioning

confidence: 99%

Effect of steroid hormones on the innate immune response induced by Staphylococcus aureus in the goat mammary gland

Kuwahara

Yoshimura

Isobe

2017

Reprod Domestic Animals

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The objective of this study was to compare the dynamics of innate immune components after intramammary infusion of Staphylococcus aureus (SA) under conditions of high oestrogen and high progesterone in goats. In one group ("E-group"), controlled internal drug release (CIDR) devices were inserted intravaginally from days -11 to -4. Prostaglandin F2α was administered immediately after removal of the CIDR device at day -3, and then oestradiol benzoate (E) was injected intramuscularly once a day from days -2 to 3. Heat-inactivated SA was then administered via intramammary infusion to the left udder at day 0, whilst only saline was infused to the right udder as a control. In a second group ("P-group"), CIDR devices were inserted intravaginally from days -3 to 7 and SA was infused at day 0 in the same way as in the E-group. The milk yield and the concentration of innate immune components (somatic cell count (SCC), lactoferrin (LF), S100A7 and goat ß-defensin 1 (GBD-1)) in the milk were measured. Milk yield decreased drastically in both SA and control udders in the E-group, whereas the P-group exhibited increased milk yield in both SA and control udders. SCC increased after SA infusion in both E- and P-groups, although it was higher in the E-group than in the P-group. There was no significant change in LF concentration in the E-group, but a decrease was observed in the P-group. Concentrations of S100A and GBD-1 were significantly increased after SA infusion in the E-group but not in the P-group. These results suggest that E enhances the innate immune response induced by SA in the goat mammary gland. This effect may be due to the reduction in milk yield and upregulation of innate immune components.

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Antimicrobial activity of bovine psoriasin

Cited by 34 publications

References 21 publications

Transcription Profiling Reveals Potential Mechanisms of Dysbiosis in the Oral Microbiome of Rhesus Macaques with Chronic Untreated SIV Infection

Transcription Profiling Reveals Potential Mechanisms of Dysbiosis in the Oral Microbiome of Rhesus Macaques with Chronic Untreated SIV Infection

Control mechanisms for producing antimicrobial factors in ruminant mammary gland

Effect of steroid hormones on the innate immune response induced by Staphylococcus aureus in the goat mammary gland

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